Gene/Proteome Database (LMPD)
LMPD ID
LMP006671
Gene ID
Species
Homo sapiens (Human)
Gene Name
SPHK1 interactor, AKAP domain containing
Gene Symbol
Synonyms
SKIP
Alternate Names
A-kinase anchor protein SPHKAP; sphingosine kinase type 1-interacting protein; SPHK1-interactor and AKAP domain-containing protein; SPHK1 (sphingosine kinase type 1) interacting protein
Chromosome
2
Map Location
2q36
Proteins
| A-kinase anchor protein SPHKAP isoform 1 | |
|---|---|
| Refseq ID | NP_001136116 |
| Protein GI | 217416354 |
| UniProt ID | Q2M3C7 |
| mRNA ID | NM_001142644 |
| Length | 1700 |
| RefSeq Status | VALIDATED |
| MDGNSLLSVPSNLESSRMYDVLEPQQGRGCGSSGSGPGNSITACKKVLRSNSLLESTDYWLQNQRMPCQIGFVEDKSENCASVCFVNLDVNKDECSTEHLQQKLVNVSPDLPKLISSMNVQQPKENEIVVLSGLASGNLQADFEVSQCPWLPDICLVQCARGNRPNSTNCIIFEINKFLIGLELVQERQLHLETNILKLEDDTNCSLSSIEEDFLTASEHLEEESEVDESRNDYENINVSANVLESKQLKGATQVEWNCNKEKWLYALEDKYINKYPTPLIKTERSPENLTKNTALQSLDPSAKPSQWKREAVGNGRQATHYYHSEAFKGQMEKSQALYIPKDAYFSMMDKDVPSACAVAEQRSNLNPGDHEDTRNALPPRQDGEVTTGKYATNLAESVLQDAFIRLSQSQSTLPQESAVSVSVGSSLLPSCYSTKDTVVSRSWNELPKIVVVQSPDGSDAAPQPGISSWPEMEVSVETSSILSGENSSRQPQSALEVALACAATVIGTISSPQATERLKMEQVVSNFPPGSSGALQTQAPQGLKEPSINEYSFPSALCGMTQVASAVAVCGLGEREEVTCSVAPSGSLPPAAEASEAMPPLCGLASMELGKEAIAKGLLKEAALVLTRPNTYSSIGDFLDSMNRRIMETASKSQTLCSENVVRNELAHTLSNVILRHSIDEVHHKNMIIDPNDNRHSSEILDTLMESTNQLLLDVICFTFKKMSHIVRLGECPAVLSKETIRRRETEPSCQPSDPGASQAWTKATESSSSSPLSNSHNTSLVINNLVDGMYSKQDKGGVRPGLFKNPTLQSQLSRSHRVPDSSTATTSSKEIYLKGIAGEDTKSPHHSENECRASSEGQRSPTVSQSRSGSQEAEESIHPNTQEKYNCATSRINEVQVNLSLLGDDLLLPAQSTLQTKHPDIYCITDFAEELADTVVSMATEIAAICLDNSSGKQPWFCAWKRGSEFLMTPNVPCRSLKRKKESQGSGTAVRKHKPPRLSEIKRKTDEHPELKEKLMNRVVDESMNLEDVPDSVNLFANEVAAKIMNLTEFSMVDGMWQAQGYPRNRLLSGDRWSRLKASSCESIPEEDSEARAYVNSLGLMSTLSQPVSRASSVSKQSSCESITDEFSRFMVNQMENEGRGFELLLDYYAGKNASSILNSAMQQACRKSDHLSVRPSCPSKQSSTESITEEFYRYMLRDIERDSRESASSRRSSQDWTAGLLSPSLRSPVCHRQSSMPDSRSPCSRLTVNVPIKANSLDGFAQNCPQDFLSVQPVSSASSSGLCKSDSCLYRRGGTDHITNMLIHETWASSIEALMRKNKIIVDDAEEADTEPVSGGSPSQAEKCANRLAASRMCSGPTLLVQESLDCPRKDSVTECKQPPVSSLSKTASLTNHSPLDSKKETSSCQDPVPINHKRRSLCSREVPLIQIETDQREACAGEPEPFLSKSSLLEEAEGHSNDKNIPDVVRGGDTAVSACQIHSDSLDTRDVPEAEASTEARAPDEAPNPPSSSEESTGSWTQLANEEDNPDDTSSFLQLSERSMSNGNSSATSSLGIMDLDIYQESMPSSPMINELVEEKKILKGQSESTEAPASGPPTGTASPQRSLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQENRIEKFLDVVQLVHRKSWKVGDIFHAVVQYCKMHEEQKDGRLSLFDWLLELG | |
| A-kinase anchor protein SPHKAP isoform 2 | |
|---|---|
| Refseq ID | NP_085126 |
| Protein GI | 217416354 |
| UniProt ID | Q2M3C7 |
| mRNA ID | NM_030623 |
| Length | 1700 |
| RefSeq Status | VALIDATED |
| MDGNSLLSVPSNLESSRMYDVLEPQQGRGCGSSGSGPGNSITACKKVLRSNSLLESTDYWLQNQRMPCQIGFVEDKSENCASVCFVNLDVNKDECSTEHLQQKLVNVSPDLPKLISSMNVQQPKENEIVVLSGLASGNLQADFEVSQCPWLPDICLVQCARGNRPNSTNCIIFEINKFLIGLELVQERQLHLETNILKLEDDTNCSLSSIEEDFLTASEHLEEESEVDESRNDYENINVSANVLESKQLKGATQVEWNCNKEKWLYALEDKYINKYPTPLIKTERSPENLTKNTALQSLDPSAKPSQWKREAVGNGRQATHYYHSEAFKGQMEKSQALYIPKDAYFSMMDKDVPSACAVAEQRSNLNPGDHEDTRNALPPRQDGEVTTGKYATNLAESVLQDAFIRLSQSQSTLPQESAVSVSVGSSLLPSCYSTKDTVVSRSWNELPKIVVVQSPDGSDAAPQPGISSWPEMEVSVETSSILSGENSSRQPQSALEVALACAATVIGTISSPQATERLKMEQVVSNFPPGSSGALQTQAPQGLKEPSINEYSFPSALCGMTQVASAVAVCGLGEREEVTCSVAPSGSLPPAAEASEAMPPLCGLASMELGKEAIAKGLLKEAALVLTRPNTYSSIGDFLDSMNRRIMETASKSQTLCSENVVRNELAHTLSNVILRHSIDEVHHKNMIIDPNDNRHSSEILDTLMESTNQLLLDVICFTFKKMSHIVRLGECPAVLSKETIRRRETEPSCQPSDPGASQAWTKATESSSSSPLSNSHNTSLVINNLVDGMYSKQDKGGVRPGLFKNPTLQSQLSRSHRVPDSSTATTSSKEIYLKGIAGEDTKSPHHSENECRASSEGQRSPTVSQSRSGSQEAEESIHPNTQEKYNCATSRINEVQVNLSLLGDDLLLPAQSTLQTKHPDIYCITDFAEELADTVVSMATEIAAICLDNSSGKQPWFCAWKRGSEFLMTPNVPCRSLKRKKESQGSGTAVRKHKPPRLSEIKRKTDEHPELKEKLMNRVVDESMNLEDVPDSVNLFANEVAAKIMNLTEFSMVDGMWQAQGYPRNRLLSGDRWSRLKASSCESIPEEDSEARAYVNSLGLMSTLSQPVSRASSVSKQSSCESITDEFSRFMVNQMENEGRGFELLLDYYAGKNASSILNSAMQQACRKSDHLSVRPSCPSKQSSTESITEEFYRYMLRDIERDSRESASSRRSSQDWTAGLLSPSLRSPVCHRQSSMPDSRSPCSRLTVNVPIKANSLDGFAQNCPQDFLSVQPVSSASSSGLCKSDSCLYRRGGTDHITNMLIHETWASSIEALMRKNKIIVDDAEEADTEPVSGGSPSQAEKCANRLAASRMCSGPTLLVQESLDCPRKDSVTECKQPPVSSLSKTASLTNHSPLDSKKETSSCQDPVPINHKRRSLCSREVPLIQIETDQREACAGEPEPFLSKSSLLEEAEGHSNDKNIPDVVRGGDTAVSACQIHSDSLDTRDVPEAEASTEARAPDEAPNPPSSSEESTGSWTQLANEEDNPDDTSSFLQLSERSMSNGNSSATSSLGIMDLDIYQESMPSSPMINELVEEKKILKGQSESTEAPASGPPTGTASPQRSLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQENRIEKFLDVVQLVHRKSWKVGDIFHAVVQYCKMHEEQKDGRLSLFDWLLELG | |
Gene Information
Entrez Gene ID
Gene Name
SPHK1 interactor, AKAP domain containing
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0030018 | IEA:Ensembl | C | Z disc |
| GO:0070062 | IDA:UniProt | C | extracellular vesicular exosome |
| GO:0005739 | IEA:Ensembl | C | mitochondrion |
| GO:0051018 | IDA:UniProtKB | F | protein kinase A binding |
Domain Information
UniProt Annotations
Entry Information
Gene Name
SPHK1 interactor, AKAP domain containing
Protein Entry
SPKAP_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q2M3C7-1; Sequence=Displayed; Name=2; IsoId=Q2M3C7-2; Sequence=VSP_031712; |
| Domain | RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer. |
| Function | Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1. |
| Interaction | Q9NYA1:SPHK1; NbExp=4; IntAct=EBI-1803914, EBI-985303; |
| Sequence Caution | Sequence=CAH18152.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; |
| Similarity | Belongs to the AKAP110 family. |
| Subcellular Location | Cytoplasm {ECO |
| Subunit | Interacts (via the PKA-RII subunit binding domain) with the RI subunit of PKA. Interacts with SPHK1; the interaction greatly reduces SPHK1 activity. {ECO |
| Tissue Specificity | Highly expressed in heart. Both isoforms abundantly expressed in ventricle. Also expressed in spleen, ovary and brain. {ECO |
Identical and Related Proteins
Unique RefSeq proteins for LMP006671 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 217416354 | RefSeq | NP_001136116 | 1700 | A-kinase anchor protein SPHKAP isoform 1 |
| 217416354 | RefSeq | NP_085126 | 1700 | A-kinase anchor protein SPHKAP isoform 2 |
Identical Sequences to LMP006671 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:217416354 | GenBank | AAI04957.1 | 1700 | SPHKAP protein [Homo sapiens] |
| GI:217416354 | GenBank | AAI04957.1 | 1700 | SPHKAP protein [Homo sapiens] |
| GI:217416354 | GenBank | AAI04955.1 | 1700 | SPHKAP protein [Homo sapiens] |
| GI:217416354 | GenBank | AAI04955.1 | 1700 | SPHKAP protein [Homo sapiens] |
| GI:217416354 | GenBank | ADR83443.1 | 1700 | SPHK1 interactor, AKAP domain containing, partial [synthetic construct] |
| GI:217416354 | GenBank | ADR83443.1 | 1700 | SPHK1 interactor, AKAP domain containing, partial [synthetic construct] |
| GI:217416354 | SwissProt | Q2M3C7.1 | 1700 | RecName: Full=A-kinase anchor protein SPHKAP; AltName: Full=SPHK1-interactor and AKAP domain-containing protein; AltName: Full=Sphingosine kinase type 1-interacting protein [Homo sapiens] |
| GI:217416354 | SwissProt | Q2M3C7.1 | 1700 | RecName: Full=A-kinase anchor protein SPHKAP; AltName: Full=SPHK1-interactor and AKAP domain-containing protein; AltName: Full=Sphingosine kinase type 1-interacting protein [Homo sapiens] |
Related Sequences to LMP006671 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:217416354 | GenBank | AIC57177.1 | 1700 | SPHKAP, partial [synthetic construct] |
| GI:217416354 | GenBank | AIC57177.1 | 1700 | SPHKAP, partial [synthetic construct] |
| GI:217416354 | RefSeq | XP_001137841.1 | 1700 | PREDICTED: A-kinase anchor protein SPHKAP isoform X4 [Pan troglodytes] |
| GI:217416354 | RefSeq | XP_001137841.1 | 1700 | PREDICTED: A-kinase anchor protein SPHKAP isoform X4 [Pan troglodytes] |
| GI:217416354 | RefSeq | XP_003821887.1 | 1700 | PREDICTED: A-kinase anchor protein SPHKAP isoform X2 [Pan paniscus] |
| GI:217416354 | RefSeq | XP_003821887.1 | 1700 | PREDICTED: A-kinase anchor protein SPHKAP isoform X2 [Pan paniscus] |
| GI:217416354 | RefSeq | XP_005246927.1 | 1683 | PREDICTED: A-kinase anchor protein SPHKAP isoform X4 [Homo sapiens] |
| GI:217416354 | RefSeq | XP_005246927.1 | 1683 | PREDICTED: A-kinase anchor protein SPHKAP isoform X4 [Homo sapiens] |
| GI:217416354 | RefSeq | XP_006712840.1 | 1725 | PREDICTED: A-kinase anchor protein SPHKAP isoform X5 [Homo sapiens] |
| GI:217416354 | RefSeq | XP_006712840.1 | 1725 | PREDICTED: A-kinase anchor protein SPHKAP isoform X5 [Homo sapiens] |
| GI:217416354 | RefSeq | XP_009442760.1 | 1709 | PREDICTED: A-kinase anchor protein SPHKAP isoform X3 [Pan troglodytes] |
| GI:217416354 | RefSeq | XP_009442760.1 | 1709 | PREDICTED: A-kinase anchor protein SPHKAP isoform X3 [Pan troglodytes] |