Gene/Proteome Database (LMPD)
LMPD ID
LMP006672
Gene ID
Species
Homo sapiens (Human)
Gene Name
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
Gene Symbol
Synonyms
FAPP2
Alternate Names
pleckstrin homology domain-containing family A member 8; PH domain-containing family A member 8; phosphoinositol 4-phosphate adapter protein 2; serologically defined breast cancer antigen NY-BR-86; phosphatidylinositol-four-phosphate adapter protein 2
Chromosome
7
Map Location
7p21-p11.2
Proteins
| pleckstrin homology domain-containing family A member 8 isoform 1 | |
|---|---|
| Refseq ID | NP_001183955 |
| Protein GI | 308153327 |
| UniProt ID | Q96JA3 |
| mRNA ID | NM_001197026 |
| Length | 519 |
| RefSeq Status | VALIDATED |
| MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSELRLYCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEECMQIANAAFTSELLYRTPPGSPQLAMLKSSKMKHPIIPIHNSLERQMELSTCENGSLNMEINGEEEILMKNKNSLYLKSAEIDCSISSEENTDDNITVQGEIRKEDGMENLKNHDNNLTQSGSDSSCSPECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAPVKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKFLKGFLTEVKNGEKDIQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAALTVKEGDHQKEAFSIGMQRDLSLYLPAMEKQLAILDTLYEVHGLESDEVV | |
| pleckstrin homology domain-containing family A member 8 isoform 2 | |
|---|---|
| Refseq ID | NP_001183956 |
| Protein GI | 308153327 |
| UniProt ID | Q96JA3 |
| mRNA ID | NM_001197027 |
| Length | 519 |
| RefSeq Status | VALIDATED |
| MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSELRLYCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEECMQIANAAFTSELLYRTPPGSPQLAMLKSSKMKHPIIPIHNSLERQMELSTCENGSLNMEINGEEEILMKNKNSLYLKSAEIDCSISSEENTDDNITVQGEIRKEDGMENLKNHDNNLTQSGSDSSCSPECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAPVKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKFLKGFLTEVKNGEKDIQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAALTVKEGDHQKEAFSIGMQRDLSLYLPAMEKQLAILDTLYEVHGLESDEVV | |
| pleckstrin homology domain-containing family A member 8 isoform 3 | |
|---|---|
| Refseq ID | NP_116028 |
| Protein GI | 14249174 |
| UniProt ID | Q96JA3 |
| mRNA ID | NM_032639 |
| Length | 440 |
| RefSeq Status | VALIDATED |
| MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSELRLYCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEECMQIANAAFTSELLYRTPPGSPQLAMLKSSKMKHPIIPIHNSLERQMELSTCENGSLNMEINGEEEILMKNKNSLYLKSAEIDCSISSEENTDDNITVQGEIRKEDGMENLKNHDNNLTQSGSDSSCSPECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAPVKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKFLKGFLTEVKNGEKDIQTALRNPTENT | |
Gene Information
Entrez Gene ID
Gene Name
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016020 | IEA:UniProtKB-KW | C | membrane |
| GO:0005802 | IDA:UniProtKB | C | trans-Golgi network |
| GO:0097001 | IDA:UniProtKB | F | ceramide binding |
| GO:0051861 | IDA:UniProtKB | F | glycolipid binding |
| GO:0017089 | IDA:UniProtKB | F | glycolipid transporter activity |
| GO:0070273 | IDA:UniProtKB | F | phosphatidylinositol-4-phosphate binding |
| GO:0035621 | IDA:UniProtKB | P | ER to Golgi ceramide transport |
| GO:0006869 | IDA:UniProtKB | P | lipid transport |
| GO:0015031 | IEA:UniProtKB-KW | P | protein transport |
Domain Information
UniProt Annotations
Entry Information
Gene Name
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
Protein Entry
PKHA8_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96JA3-1; Sequence=Displayed; Name=2; IsoId=Q96JA3-2; Sequence=VSP_028545, VSP_028546; Note=No experimental confirmation available.; Name=3; IsoId=Q96JA3-3; Sequence=VSP_028543, VSP_028544; Note=No experimental confirmation available.; |
| Domain | The PH domain of FAPPS binds the small GTPase ARF1 and phosphatidylinositol-4-phosphate (PtdIns4P) with high selectivity, and is required for recruitment of FAPPs to the trans-Golgi network (TGN). |
| Function | Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation. {ECO |
| Sequence Caution | Sequence=AAG48267.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=AAK55424.1; Type=Erroneous termination; Positions=508; Note=Translated as Tyr.; Evidence= ; |
| Similarity | Contains 1 PH domain. {ECO |
| Subcellular Location | Cytoplasm. Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein. Note=Mainly localized to the trans-Golgi network (TGN) but also found at the rims of Golgi cisternae. Associates with ARF1 at Golgi apparatus membranes. |
| Subunit | Homodimer (By similarity). Interacts with ARF1; the interaction together with phosphatidylinositol 4-phosphate binding is required for FAPP2 GlcCer transfer ability. {ECO |
| Tissue Specificity | Expressed in kidney cell lines. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006672 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 308153327 | RefSeq | NP_001183955 | 519 | pleckstrin homology domain-containing family A member 8 isoform 1 |
| 308153327 | RefSeq | NP_001183956 | 519 | pleckstrin homology domain-containing family A member 8 isoform 2 |
| 14249174 | RefSeq | NP_116028 | 440 | pleckstrin homology domain-containing family A member 8 isoform 3 |
Identical Sequences to LMP006672 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:308153327 | DBBJ | BAG57961.1 | 519 | unnamed protein product [Homo sapiens] |
| GI:308153327 | DBBJ | BAG57961.1 | 519 | unnamed protein product [Homo sapiens] |
| GI:14249174 | GenBank | AAH02838.1 | 440 | Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 [Homo sapiens] |
| GI:308153327 | GenBank | EAW93930.1 | 519 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8, isoform CRA_a [Homo sapiens] |
| GI:308153327 | GenBank | EAW93930.1 | 519 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8, isoform CRA_a [Homo sapiens] |
| GI:14249174 | GenBank | ABM84424.1 | 440 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 [synthetic construct] |
| GI:14249174 | GenBank | ABM87457.1 | 440 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8, partial [synthetic construct] |
| GI:14249174 | GenBank | AEP73936.1 | 440 | Sequence 12 from patent US 8012948 |
| GI:14249174 | GenBank | AHD73290.1 | 440 | Sequence 10358 from patent US 8586006 |
| GI:308153327 | SwissProt | Q96JA3.3 | 519 | RecName: Full=Pleckstrin homology domain-containing family A member 8; Short=PH domain-containing family A member 8; AltName: Full=Phosphatidylinositol-four-phosphate adapter protein 2; Short=FAPP-2; Short=Phosphoinositol 4-phosphate adapter protein 2; Short=hFAPP2; AltName: Full=Serologically defined breast cancer antigen NY-BR-86 [Homo sapiens] |
| GI:308153327 | SwissProt | Q96JA3.3 | 519 | RecName: Full=Pleckstrin homology domain-containing family A member 8; Short=PH domain-containing family A member 8; AltName: Full=Phosphatidylinositol-four-phosphate adapter protein 2; Short=FAPP-2; Short=Phosphoinositol 4-phosphate adapter protein 2; Short=hFAPP2; AltName: Full=Serologically defined breast cancer antigen NY-BR-86 [Homo sapiens] |
Related Sequences to LMP006672 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:308153327 | GenBank | JAA08020.1 | 519 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 [Pan troglodytes] |
| GI:308153327 | GenBank | JAA08020.1 | 519 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 [Pan troglodytes] |
| GI:308153327 | GenBank | JAA20175.1 | 519 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 [Pan troglodytes] |
| GI:308153327 | GenBank | JAA20175.1 | 519 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 [Pan troglodytes] |
| GI:308153327 | GenBank | JAA31720.1 | 519 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 [Pan troglodytes] |
| GI:308153327 | GenBank | JAA31720.1 | 519 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 [Pan troglodytes] |
| GI:308153327 | RefSeq | NP_001186008.1 | 519 | pleckstrin homology domain-containing family A member 8 [Pan troglodytes] |
| GI:308153327 | RefSeq | NP_001186008.1 | 519 | pleckstrin homology domain-containing family A member 8 [Pan troglodytes] |
| GI:308153327 | RefSeq | XP_003833423.1 | 519 | PREDICTED: pleckstrin homology domain-containing family A member 8 isoform X1 [Pan paniscus] |
| GI:308153327 | RefSeq | XP_003833423.1 | 519 | PREDICTED: pleckstrin homology domain-containing family A member 8 isoform X1 [Pan paniscus] |
| GI:308153327 | RefSeq | XP_004045293.1 | 519 | PREDICTED: pleckstrin homology domain-containing family A member 8 isoform 1 [Gorilla gorilla gorilla] |
| GI:308153327 | RefSeq | XP_004045293.1 | 519 | PREDICTED: pleckstrin homology domain-containing family A member 8 isoform 1 [Gorilla gorilla gorilla] |
| GI:14249174 | RefSeq | XP_004045295.1 | 440 | PREDICTED: pleckstrin homology domain-containing family A member 8 isoform 3 [Gorilla gorilla gorilla] |
| GI:14249174 | RefSeq | XP_008957133.1 | 440 | PREDICTED: pleckstrin homology domain-containing family A member 8 isoform X3 [Pan paniscus] |
| GI:14249174 | RefSeq | XP_009201431.1 | 440 | PREDICTED: pleckstrin homology domain-containing family A member 8 isoform X3 [Papio anubis] |
| GI:14249174 | RefSeq | XP_009241166.1 | 440 | PREDICTED: pleckstrin homology domain-containing family A member 8 isoform X3 [Pongo abelii] |
| GI:14249174 | RefSeq | XP_009450810.1 | 440 | PREDICTED: pleckstrin homology domain-containing family A member 8 isoform X4 [Pan troglodytes] |
| GI:14249174 | RefSeq | XP_010374961.1 | 440 | PREDICTED: pleckstrin homology domain-containing family A member 8 isoform X2 [Rhinopithecus roxellana] |