Gene/Proteome Database (LMPD)

LMPD ID
LMP006675
Gene ID
65985
Species
Homo sapiens (Human)
Gene Name
acetoacetyl-CoA synthetase
Gene Symbol
AACS
Synonyms
ACSF1; SUR-5
Alternate Names
acetoacetyl-CoA synthetase; protein sur-5 homolog; acetoacetate-CoA ligase; acyl-CoA synthetase family member 1; homolog of C. elegans supressor of ras 5 (sur-5)
Chromosome
12
Map Location
12q24.31
EC Number
6.2.1.16

Proteins

acetoacetyl-CoA synthetase
Refseq ID NP_076417
Protein GI 31982927
UniProt ID Q86V21
mRNA ID NM_023928
Length 672
RefSeq Status VALIDATED
MSKEERPGREEILECQVMWEPDSKKNTQMDRFRAAVGAACGLALESYDDLYHWSVESYSDFWAEFWKFSGIVFSRVYDEVVDTSKGIADVPEWFKGSRLNYAENLLRHKENDRVALYIAREGKEEIVKVTFEELRQEVALFAAAMRKMGVKKGDRVVGYLPNSEHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHNHMEKLQQVVKGLPDLKKVVVIPYVSSRENIDLSKIPNSVFLDDFLATGTSEQAPQLEFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHLLHGNMTSSDILLCYTTVGWMMWNWMVSLLATGAAMVLYDGSPLVPTPNVLWDLVDRIGITVLVTGAKWLSVLEEKAMKPVETHSLQMLHTILSTGSPLKAQSYEYVYRCIKSSILLGSISGGTDIISCFMGHNFSLPVYKGEIQARNLGMAVEAWNEEGKAVWGESGELVCTKPIPCQPTHFWNDENGNKYRKAYFSKFPGIWAHGDYCRINPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVESFEEVEDSLCVPQYNKYREERVILFLKMASGHAFQPDLVKRIRDAIRMGLSARHVPSLILETKGIPYTLNGKKVEVAVKQIIAGKAVEQGGAFSNPETLDLYRDIPELQGF

Gene Information

Entrez Gene ID
65985
Gene Name
acetoacetyl-CoA synthetase
Gene Symbol
AACS
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0030729 IEA:UniProtKB-EC F acetoacetate-CoA ligase activity
GO:0047760 IEA:Ensembl F butyrate-CoA ligase activity
GO:0060612 IEA:Ensembl P adipose tissue development
GO:0071397 IEA:Ensembl P cellular response to cholesterol
GO:0071333 IEA:Ensembl P cellular response to glucose stimulus
GO:0071394 IEA:Ensembl P cellular response to testosterone stimulus
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process
GO:0001889 IEA:Ensembl P liver development
GO:0032024 IEA:Ensembl P positive regulation of insulin secretion
GO:0042493 IEA:Ensembl P response to drug
GO:0045471 IEA:Ensembl P response to ethanol
GO:0007584 IEA:Ensembl P response to nutrient
GO:0034201 IEA:Ensembl P response to oleic acid
GO:0014074 IEA:Ensembl P response to purine-containing compound
GO:0042594 IEA:Ensembl P response to starvation
GO:0050872 IEA:Ensembl P white fat cell differentiation

KEGG Pathway Links

KEGG Pathway ID Description
hsa00650 Butanoate metabolism
ko00650 Butanoate metabolism

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase
IPR005914 Acetoacetyl-CoA synthase

UniProt Annotations

Entry Information

Gene Name
acetoacetyl-CoA synthetase
Protein Entry
AACS_HUMAN
UniProt ID
Q86V21
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q86V21-1; Sequence=Displayed; Name=2; IsoId=Q86V21-2; Sequence=VSP_030702; Note=No experimental confirmation available.; Name=3; IsoId=Q86V21-3; Sequence=VSP_030701; Note=No experimental confirmation available.;
Catalytic Activity ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA.
Function Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).
Sequence Caution Sequence=AAH41000.1; Type=Frameshift; Positions=201; Evidence= ; Sequence=BAB14793.1; Type=Frameshift; Positions=519; Evidence= ;
Similarity Belongs to the ATP-dependent AMP-binding enzyme family.
Subcellular Location Cytoplasm, cytosol .
Tissue Specificity Highly expressed in kidney, heart and brain, but low in liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP006675 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31982927 RefSeq NP_076417 672 acetoacetyl-CoA synthetase

Identical Sequences to LMP006675 proteins

Reference Database Accession Length Protein Name
GI:31982927 GenBank EAW98475.1 672 acetoacetyl-CoA synthetase, isoform CRA_b [Homo sapiens]
GI:31982927 GenBank ABY09484.1 672 Sequence 78 from patent US 7301016
GI:31982927 GenBank ADS47661.1 672 Sequence 35 from patent US 7799898
GI:31982927 GenBank AED35488.1 672 Sequence 152 from patent US 7879989
GI:31982927 GenBank AED82308.1 672 Sequence 1045 from patent US 7919467
GI:31982927 GenBank AFQ88734.1 672 Sequence 35 from patent US 8252915

Related Sequences to LMP006675 proteins

Reference Database Accession Length Protein Name
GI:31982927 GenBank AAH40490.2 672 Acetoacetyl-CoA synthetase [Homo sapiens]
GI:31982927 GenBank JAA04609.1 672 acetoacetyl-CoA synthetase [Pan troglodytes]
GI:31982927 GenBank JAA16763.1 672 acetoacetyl-CoA synthetase [Pan troglodytes]
GI:31982927 GenBank JAA29397.1 672 acetoacetyl-CoA synthetase [Pan troglodytes]
GI:31982927 GenBank JAA35643.1 672 acetoacetyl-CoA synthetase [Pan troglodytes]
GI:31982927 RefSeq XP_003817902.1 672 PREDICTED: acetoacetyl-CoA synthetase isoform X1 [Pan paniscus]