Gene/Proteome Database (LMPD)

LMPD ID
LMP006677
Gene ID
563
Species
Homo sapiens (Human)
Gene Name
alpha-2-glycoprotein 1, zinc-binding
Gene Symbol
AZGP1
Synonyms
ZA2G; ZAG
Alternate Names
zinc-alpha-2-glycoprotein; zn-alpha-2-GP; Zn-alpha2-glycoprotein; zn-alpha-2-glycoprotein; Alpha-2-glycoprotein, zinc
Chromosome
7
Map Location
7q22.1

Proteins

zinc-alpha-2-glycoprotein precursor
Refseq ID NP_001176
Protein GI 4502337
UniProt ID P25311
mRNA ID NM_001185
Length 298
RefSeq Status VALIDATED
MVRMVPVLLSLLLLLGPAVPQENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFFRYNSKDRKSQPMGLWRQVEGMEDWKQDSQLQKAREDIFMETLKDIVEYYNDSNGSHVLQGRFGCEIENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYVQRAKAYLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKIDVHWTRAGEVQEPELRGDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVVPWEAS
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2132 peptide sequence: MVRMVPVLLSLLLLLGPAVP mat_peptide: 21..298 product: Zinc-alpha-2-glycoprotein experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P25311.2) calculated_mol_wt: 32145 peptide sequence: QENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFFRYNSKDRKSQPMGLWRQVEGMEDWKQDSQLQKAREDIFMETLKDIVEYYNDSNGSHVLQGRFGCEIENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYVQRAKAYLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKIDVHWTRAGEVQEPELRGDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVVPWEAS

Gene Information

Entrez Gene ID
563
Gene Name
alpha-2-glycoprotein 1, zinc-binding
Gene Symbol
AZGP1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042612 IEA:InterPro C MHC class I protein complex
GO:0005576 NAS:UniProtKB C extracellular region
GO:0005615 IDA:UniProt C extracellular space
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0005634 IDA:UniProt C nucleus
GO:0001948 IPI:UniProt F glycoprotein binding
GO:0042605 IEA:InterPro F peptide antigen binding
GO:0008320 NAS:UniProtKB F protein transmembrane transporter activity
GO:0004540 NAS:UniProtKB F ribonuclease activity
GO:0090501 NAS:GOC P RNA phosphodiester bond hydrolysis
GO:0002474 IEA:InterPro P antigen processing and presentation of peptide antigen via MHC class I
GO:0007155 IDA:UniProtKB P cell adhesion
GO:0001580 IDA:UniProt P detection of chemical stimulus involved in sensory perception of bitter taste
GO:0006955 IEA:InterPro P immune response
GO:0008285 NAS:UniProtKB P negative regulation of cell proliferation
GO:0001916 IEA:InterPro P positive regulation of T cell mediated cytotoxicity
GO:0071806 NAS:GOC P protein transmembrane transport
GO:0001895 IEP:UniProt P retina homeostasis

Domain Information

InterPro Annotations

Accession Description
IPR003597 Immunoglobulin C1-set
IPR007110 Immunoglobulin-like domain
IPR013783 Immunoglobulin-like fold
IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
IPR027648 MHC class I alpha chain
IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
IPR011161 MHC class I-like antigen recognition
IPR011162 MHC classes I/II-like antigen recognition protein

UniProt Annotations

Entry Information

Gene Name
alpha-2-glycoprotein 1, zinc-binding
Protein Entry
ZA2G_HUMAN
UniProt ID
P25311
Species
Human

Comments

Comment Type Description
Caution It is uncertain whether Met-1 or Met-4 is the initiator.
Function Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.
Ptm N-glycosylated. N-glycan at Asn-128: Hex5HexNAc4. {ECO
Sequence Caution Sequence=AAA61311.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=BAA03123.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAA14417.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=CAA42438.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Similarity Belongs to the MHC class I family.
Similarity Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Subcellular Location Secreted.
Subunit Interacts with PIP.
Tissue Specificity Blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various human glands, liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP006677 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4502337 RefSeq NP_001176 298 zinc-alpha-2-glycoprotein precursor

Identical Sequences to LMP006677 proteins

Reference Database Accession Length Protein Name
GI:4502337 GenBank ADT50815.1 298 Sequence 2832 from patent US 7842467
GI:4502337 GenBank AED39194.1 298 Sequence 1197 from patent US 7883858
GI:4502337 GenBank AED39352.1 298 Sequence 1512 from patent US 7883858
GI:4502337 GenBank AGU27925.1 298 Sequence 15 from patent US 8497078
GI:4502337 GenBank AHD74875.1 298 Sequence 15579 from patent US 8586006
GI:4502337 GenBank AIC54058.1 298 AZGP1, partial [synthetic construct]

Related Sequences to LMP006677 proteins

Reference Database Accession Length Protein Name
GI:4502337 EMBL CAA42438.1 302 Zn-alpha2-glycoprotein [Homo sapiens]
GI:4502337 GenBank AAH05306.1 298 Alpha-2-glycoprotein 1, zinc-binding [Homo sapiens]
GI:4502337 GenBank AGB62528.1 315 Sequence 89 from patent US 8288091
GI:4502337 PRF - 302 Zn alpha2 glycoprotein [Homo sapiens]
GI:4502337 RefSeq XP_001143820.1 298 PREDICTED: zinc-alpha-2-glycoprotein [Pan troglodytes]
GI:4502337 RefSeq XP_003815773.1 298 PREDICTED: zinc-alpha-2-glycoprotein [Pan paniscus]