Gene/Proteome Database (LMPD)

LMPD ID
LMP006679
Gene ID
27132
Species
Homo sapiens (Human)
Gene Name
copine VII
Gene Symbol
CPNE7
Synonyms
-
Alternate Names
copine-7; copine 7
Chromosome
16
Map Location
16q24.3
Summary
This gene encodes a member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains and one von Willebrand factor A domain. The encoded protein may be involved in membrane trafficking. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Orthologs
View orthologs and multiple alignments for CPNE7

Proteins

copine-7 isoform a
Refseq ID NP_705900
Protein GI 25141328
UniProt ID Q9UBL6
mRNA ID NM_153636
Length 558
RefSeq Status REVIEWED
MSAGSERGAAATPGGLPAPCASKVELRLSCRHLLDRDPLTKSDPSVALLQQAQGQWVQVGRTEVVRSSLHPVFSKVFTVDYYFEEVQRLRFEVYDTHGPSGFSCQEDDFLGGMECTLGQIVAQKKVTRPLLLKFGRNAGKSTITVIAEDISGNNGYVELSFRARKLDDKDLFSKSDPFLELYRVNDDQGLQLVYRTEVVKNNLNPVWEAFKVSLSSLCSCEETRPLKCLVWDYDSRGKHDFIGEFSTTFEEMQKAFEEGQAQWDCVNPKYKQKRRSYKNSGVVVLADLKFHRVYSFLDYIMGGCQIHFTVAIDFTASNGDPRNSCSLHYINPYQPNEYLKALVSVGEICQDYDSDKRFSALGFGARIPPKYEVSHDFAINFNPEDDECEGIQGVVEAYQNCLPRVQLYGPTNVAPIISKVARVAAAEESTGKASQYYILLILTDGVVTDMADTREAIVRASRLPMSIIIVGVGNADFTDMQVLDGDDGVLRSPRGEPALRDIVQFVPFRELKNASPAALAKCVLAEVPKQVVEYYSHRGLPPRSLGVPAGEASPGCTP
copine-7 isoform b
Refseq ID NP_055242
Protein GI 7656993
UniProt ID Q9UBL6
mRNA ID NM_014427
Length 633
RefSeq Status REVIEWED
MSAGSERGAAATPGGLPAPCASKVELRLSCRHLLDRDPLTKSDPSVALLQQAQGQWVQVGRTEVVRSSLHPVFSKVFTVDYYFEEVQRLRFEVYDTHGPSGFSCQEDDFLGGMECTLGQPAQKWLLQVVMRVSVDVLGPAGHCAKHFLCCTESSHLARTGPSFLLRYDDLCLPWATAGAVRWWTCRGGHTQGWQIVAQKKVTRPLLLKFGRNAGKSTITVIAEDISGNNGYVELSFRARKLDDKDLFSKSDPFLELYRVNDDQGLQLVYRTEVVKNNLNPVWEAFKVSLSSLCSCEETRPLKCLVWDYDSRGKHDFIGEFSTTFEEMQKAFEEGQAQWDCVNPKYKQKRRSYKNSGVVVLADLKFHRVYSFLDYIMGGCQIHFTVAIDFTASNGDPRNSCSLHYINPYQPNEYLKALVSVGEICQDYDSDKRFSALGFGARIPPKYEVSHDFAINFNPEDDECEGIQGVVEAYQNCLPRVQLYGPTNVAPIISKVARVAAAEESTGKASQYYILLILTDGVVTDMADTREAIVRASRLPMSIIIVGVGNADFTDMQVLDGDDGVLRSPRGEPALRDIVQFVPFRELKNASPAALAKCVLAEVPKQVVEYYSHRGLPPRSLGVPAGEASPGCTP

Gene Information

Entrez Gene ID
27132
Gene Name
copine VII
Gene Symbol
CPNE7
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0005215 TAS:ProtInc F transporter activity
GO:0006629 TAS:ProtInc P lipid metabolic process
GO:0006810 TAS:GOC P transport

Domain Information

InterPro Annotations

Accession Description
IPR000008 C2 domain
IPR010734 Copine
IPR002035 von Willebrand factor, type A

UniProt Annotations

Entry Information

Gene Name
copine VII
Protein Entry
CPNE7_HUMAN
UniProt ID
Q9UBL6
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UBL6-1; Sequence=Displayed; Name=2; IsoId=Q9UBL6-2; Sequence=VSP_001215; Note=No experimental confirmation available.;
Function May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity).
Similarity Belongs to the copine family.
Similarity Contains 1 VWFA domain. {ECO
Similarity Contains 2 C2 domains. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP006679 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
25141328 RefSeq NP_705900 558 copine-7 isoform a
7656993 RefSeq NP_055242 633 copine-7 isoform b

Identical Sequences to LMP006679 proteins

Reference Database Accession Length Protein Name
GI:25141328 DBBJ BAG73056.1 558 copine VII, partial [synthetic construct]
GI:7656993 EMBL CAB61431.1 633 copine VII protein [Homo sapiens]
GI:7656993 EMBL CAB61446.1 633 copine VII protein [Homo sapiens]
GI:25141328 GenBank AAH35334.1 558 Copine VII [Homo sapiens]
GI:25141328 GenBank AAH64577.1 558 CPNE7 protein [Homo sapiens]
GI:25141328 GenBank ADZ15445.1 558 copine VII, partial [synthetic construct]
GI:7656993 GenBank AHE00963.1 633 Sequence 55342 from patent US 8586006
GI:25141328 GenBank AHE00964.1 558 Sequence 55343 from patent US 8586006
GI:25141328 GenBank AIC56224.1 558 CPNE7, partial [synthetic construct]
GI:7656993 SwissProt Q9UBL6.1 633 RecName: Full=Copine-7; AltName: Full=Copine VII [Homo sapiens]

Related Sequences to LMP006679 proteins

Reference Database Accession Length Protein Name
GI:7656993 GenBank AAH64577.1 558 CPNE7 protein [Homo sapiens]
GI:7656993 GenBank EAW66721.1 584 copine VII, isoform CRA_a [Homo sapiens]
GI:25141328 GenBank AFE69732.1 542 copine-7 isoform a, partial [Macaca mulatta]
GI:25141328 GenBank JAA24386.1 558 copine VII [Pan troglodytes]
GI:7656993 GenBank ELR58752.1 558 Copine-7, partial [Bos mutus]
GI:25141328 GenBank JAB12083.1 561 copine-7 isoform a [Callithrix jacchus]
GI:7656993 GenBank AHE00964.1 558 Sequence 55343 from patent US 8586006
GI:7656993 GenBank AIC56224.1 558 CPNE7, partial [synthetic construct]
GI:25141328 RefSeq XP_002826814.1 562 PREDICTED: LOW QUALITY PROTEIN: copine-7 [Pongo abelii]
GI:7656993 RefSeq XP_004087558.1 891 PREDICTED: LOW QUALITY PROTEIN: copine-7 [Nomascus leucogenys]
GI:25141328 RefSeq XP_009195338.1 558 PREDICTED: copine-7 [Papio anubis]
GI:25141328 RefSeq XP_009429721.1 562 PREDICTED: LOW QUALITY PROTEIN: copine-7 [Pan troglodytes]