Gene/Proteome Database (LMPD)

LMPD ID
LMP006680
Gene ID
412
Species
Homo sapiens (Human)
Gene Name
steroid sulfatase (microsomal), isozyme S
Gene Symbol
STS
Synonyms
ARSC; ARSC1; ASC; ES; SSDD; XLI
Alternate Names
steryl-sulfatase; arylsulfatase C; estrone sulfatase; steryl-sulfate sulfohydrolase
Chromosome
X
Map Location
Xp22.32
EC Number
3.1.6.2
Summary
The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to estrogens during pregnancy. The encoded protein is found in the endoplasmic reticulum, where it acts as a homodimer. Mutations in this gene are known to cause X-linked ichthyosis (XLI). [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for STS

Proteins

steryl-sulfatase precursor
Refseq ID NP_000342
Protein GI 53831991
UniProt ID P08842
mRNA ID NM_000351
Length 583
RefSeq Status REVIEWED
MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR
sig_peptide: 1..21 calculated_mol_wt: 2610 peptide sequence: MPLRKMKIPFLLLFFLWEAES mat_peptide: 22..583 product: steryl-sulfatase calculated_mol_wt: 62900 peptide sequence: HAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR

Gene Information

Entrez Gene ID
412
Gene Name
steroid sulfatase (microsomal), isozyme S
Gene Symbol
STS
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 TAS:ProtInc C endoplasmic reticulum
GO:0005788 TAS:Reactome C endoplasmic reticulum lumen
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0005768 TAS:ProtInc C endosome
GO:0005794 TAS:ProtInc C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0043231 TAS:ProtInc C intracellular membrane-bounded organelle
GO:0005764 TAS:ProtInc C lysosome
GO:0016020 TAS:ProtInc C membrane
GO:0005886 TAS:ProtInc C plasma membrane
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004773 TAS:Reactome F steryl-sulfatase activity
GO:0008484 IDA:MGI F sulfuric ester hydrolase activity
GO:0044267 TAS:Reactome P cellular protein metabolic process
GO:0008544 TAS:ProtInc P epidermis development
GO:0007565 IEA:UniProtKB-KW P female pregnancy
GO:0006687 TAS:Reactome P glycosphingolipid metabolic process
GO:0043687 TAS:Reactome P post-translational protein modification
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006665 TAS:Reactome P sphingolipid metabolic process
GO:0006706 TAS:ProtInc P steroid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00140 Steroid hormone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_116105 Glycosphingolipid metabolism
REACT_121036 The activation of arylsulfatases

Domain Information

InterPro Annotations

Accession Description
IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
IPR017850 Alkaline-phosphatase-like, core domain
IPR000917 Sulfatase
IPR024607 Sulfatase, conserved site

UniProt Annotations

Entry Information

Gene Name
steroid sulfatase (microsomal), isozyme S
Protein Entry
STS_HUMAN
UniProt ID
P08842
Species
Human

Comments

Comment Type Description
Catalytic Activity 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H(2)O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.
Cofactor Name=Ca(2+); Xref=ChEBI
Disease Ichthyosis, X-linked (IXL) [MIM
Function Conversion of sulfated steroid precursors to estrogens during pregnancy.
Ptm The conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
Similarity Belongs to the sulfatase family.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Subunit Homodimer.
Web Resource Name=Wikipedia; Note=Steroid sulfatase entry; URL="http://en.wikipedia.org/wiki/Steroid_sulfatase";

Identical and Related Proteins

Unique RefSeq proteins for LMP006680 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
53831991 RefSeq NP_000342 583 steryl-sulfatase precursor

Identical Sequences to LMP006680 proteins

Reference Database Accession Length Protein Name
GI:53831991 DBBJ BAG36744.1 583 unnamed protein product [Homo sapiens]
GI:53831991 GenBank AAA60597.1 583 steroid sulfatase precursor (EC 3.1.6.2) [Homo sapiens]
GI:53831991 GenBank AAQ46777.1 583 Sequence 1 from patent US 6585954
GI:53831991 GenBank AAH75030.1 583 Steroid sulfatase (microsomal), isozyme S [Homo sapiens]
GI:53831991 GenBank AFQ69837.1 583 Sequence 19 from patent US 8227212
GI:53831991 GenBank AIC54033.1 583 STS, partial [synthetic construct]

Related Sequences to LMP006680 proteins

Reference Database Accession Length Protein Name
GI:53831991 GenBank AAA60596.1 583 steroid sulfatase precursor (EC 3.1.6.2) [Homo sapiens]
GI:53831991 GenBank AAE54391.1 583 Sequence 14 from patent US 6153188
GI:53831991 GenBank AAP61636.1 583 Sequence 14 from patent US 6541254
GI:53831991 pat US 583 Sequence 9 from patent US 5627050
GI:53831991 pat US 583 Sequence 14 from patent US 5728381
GI:53831991 pat US 583 Sequence 14 from patent US 5798239