Gene/Proteome Database (LMPD)

LMPD ID
LMP006683
Gene ID
8578
Species
Homo sapiens (Human)
Gene Name
scavenger receptor class F, member 1
Gene Symbol
SCARF1
Synonyms
SREC; SREC-I; SREC1
Chromosome
17
Map Location
17p13.3
Summary
The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Orthologs
View orthologs and multiple alignments for SCARF1

Proteins

scavenger receptor class F member 1 isoform 1 precursor
Refseq ID NP_003684
Protein GI 33598929
UniProt ID Q14162
mRNA ID NM_003693
Length 830
RefSeq Status REVIEWED
MGLGLLLPLLLLWTRGTQGSELDPKGQHVCVASSPSAELQCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRGRCSAASGECTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPEGLCHPVSGSCQPGSGSRDTALIAGSLVPLLLLFLGLACCACCCWAPRSDLKDRPARDGATVSRMKLQVWGTLTSLGSTLPCRSLSSHKLPWVTVSHHDPEVPFNHSFIEPPSAGWATDDSFSSDPESGEADEVPAYCVPPQEGMVPVAQAGSSEASLAAGAFPPPEDASTPFAIPRTSSLARAKRPSVSFAEGTKFAPQSRRSSGELSSPLRKPKRLSRGAQSGPEGREAEESTGPEEAEAPESFPAAASPGDSATGHRRPPLGGRTVAEHVEAIEGSVQESSGPVTTIYMLAGKPRGSEGPVRSVFRHFGSFQKGQAEAKVKRAIPKPPRQALNRKKGSPGLASGSVGQSPNSAPKAGLPGATGPMAVRPEEAVRGLGAGTESSRRAQEPVSGCGSPEQDPQKQAEEERQEEPEYENVVPISRPPEP
scavenger receptor class F member 1 isoform 3 precursor
Refseq ID NP_663325
Protein GI 33598929
UniProt ID Q14162
mRNA ID NM_145350
Length 830
RefSeq Status REVIEWED
MGLGLLLPLLLLWTRGTQGSELDPKGQHVCVASSPSAELQCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRGRCSAASGECTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPEGLCHPVSGSCQPGSGSRDTALIAGSLVPLLLLFLGLACCACCCWAPRSDLKDRPARDGATVSRMKLQVWGTLTSLGSTLPCRSLSSHKLPWVTVSHHDPEVPFNHSFIEPPSAGWATDDSFSSDPESGEADEVPAYCVPPQEGMVPVAQAGSSEASLAAGAFPPPEDASTPFAIPRTSSLARAKRPSVSFAEGTKFAPQSRRSSGELSSPLRKPKRLSRGAQSGPEGREAEESTGPEEAEAPESFPAAASPGDSATGHRRPPLGGRTVAEHVEAIEGSVQESSGPVTTIYMLAGKPRGSEGPVRSVFRHFGSFQKGQAEAKVKRAIPKPPRQALNRKKGSPGLASGSVGQSPNSAPKAGLPGATGPMAVRPEEAVRGLGAGTESSRRAQEPVSGCGSPEQDPQKQAEEERQEEPEYENVVPISRPPEP
sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2053 peptide sequence: MGLGLLLPLLLLWTRGTQG mat_peptide: 20..830 product: Scavenger receptor class F member 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q14162.3) calculated_mol_wt: 85353 peptide sequence: SELDPKGQHVCVASSPSAELQCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRGRCSAASGECTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPEGLCHPVSGSCQPGSGSRDTALIAGSLVPLLLLFLGLACCACCCWAPRSDLKDRPARDGATVSRMKLQVWGTLTSLGSTLPCRSLSSHKLPWVTVSHHDPEVPFNHSFIEPPSAGWATDDSFSSDPESGEADEVPAYCVPPQEGMVPVAQAGSSEASLAAGAFPPPEDASTPFAIPRTSSLARAKRPSVSFAEGTKFAPQSRRSSGELSSPLRKPKRLSRGAQSGPEGREAEESTGPEEAEAPESFPAAASPGDSATGHRRPPLGGRTVAEHVEAIEGSVQESSGPVTTIYMLAGKPRGSEGPVRSVFRHFGSFQKGQAEAKVKRAIPKPPRQALNRKKGSPGLASGSVGQSPNSAPKAGLPGATGPMAVRPEEAVRGLGAGTESSRRAQEPVSGCGSPEQDPQKQAEEERQEEPEYENVVPISRPPEP sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2053 peptide sequence: MGLGLLLPLLLLWTRGTQG mat_peptide: 20..569 product: scavenger receptor class F member 1 isoform 3 calculated_mol_wt: 58786 peptide sequence: SELDPKGQHVCVASSPSAELQCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRGRCSAASGECTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPEGLCHPVSGSCQPGSGSRDTALIAGSLVPLLLLFLGLACCACCCWAPRSDLKDRPARDGATVSRMKLQVWGTLTSLGSTLPCRSLSSHKLPWVTASSSRPLPAGPLMTPSHPILSLERQMRFLPTVCHPKKGWSLWPRQGRQRPAWLQVLSRPLRTPPRHSPSRAPPA

Gene Information

Entrez Gene ID
8578
Gene Name
scavenger receptor class F, member 1
Gene Symbol
SCARF1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030666 TAS:Reactome C endocytic vesicle membrane
GO:0016021 IDA:UniProtKB C integral component of membrane
GO:0005886 TAS:Reactome C plasma membrane
GO:0030169 IDA:UniProtKB F low-density lipoprotein particle binding
GO:0005044 IDA:UniProtKB F scavenger receptor activity
GO:0004888 TAS:UniProtKB F transmembrane signaling receptor activity
GO:0007155 IEA:UniProtKB-KW P cell adhesion
GO:0006707 IC:UniProtKB P cholesterol catabolic process
GO:0016358 IEA:Ensembl P dendrite development
GO:0016322 ISS:UniProtKB P neuron remodeling
GO:0048680 ISS:UniProtKB P positive regulation of axon regeneration
GO:0010976 ISS:UniProtKB P positive regulation of neuron projection development
GO:0006898 TAS:UniProtKB P receptor-mediated endocytosis
GO:0007165 TAS:GOC P signal transduction

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_160300 Binding and Uptake of Ligands by Scavenger Receptors
REACT_163813 Scavenging by Class F Receptors

Domain Information

InterPro Annotations

Accession Description
IPR013032 EGF-like, conserved site
IPR002049 EGF-like, laminin
IPR000742 Epidermal growth factor-like domain
IPR009030 Insulin-like growth factor binding protein, N-terminal

UniProt Annotations

Entry Information

Gene Name
scavenger receptor class F, member 1
Protein Entry
SREC_HUMAN
UniProt ID
Q14162
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=SREC-1; IsoId=Q14162-1; Sequence=Displayed; Name=2; Synonyms=SREC-5; IsoId=Q14162-2; Sequence=VSP_039956; Name=3; Synonyms=SREC-3; IsoId=Q14162-3; Sequence=VSP_039960, VSP_039961; Name=4; Synonyms=SREC-4; IsoId=Q14162-4; Sequence=VSP_039957; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=5; Synonyms=SREC-2; IsoId=Q14162-5; Sequence=VSP_039958, VSP_039959; Note=No experimental confirmation available.;
Function Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity).
Similarity Contains 6 EGF-like domains. {ECO
Subcellular Location Membrane ; Single-pass type I membrane protein .
Subunit Heterophilic interaction with SREC2 via its extracellular domain. The heterophilic interaction is suppressed by the presence of ligand such as Ac-LDL. Interacts with AVIL (By similarity).
Tissue Specificity Endothelial cells.

Identical and Related Proteins

Unique RefSeq proteins for LMP006683 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
33598929 RefSeq NP_003684 830 scavenger receptor class F member 1 isoform 1 precursor
33598929 RefSeq NP_663325 830 scavenger receptor class F member 1 isoform 3 precursor

Identical Sequences to LMP006683 proteins

Reference Database Accession Length Protein Name
GI:33598929 GenBank ADS49392.1 830 Sequence 82 from patent US 7803637
GI:33598929 GenBank ADS49392.1 830 Sequence 82 from patent US 7803637
GI:33598929 GenBank AGV80647.1 830 Sequence 82 from patent US 8524218
GI:33598929 GenBank AGV80647.1 830 Sequence 82 from patent US 8524218
GI:33598929 SwissProt Q14162.3 830 RecName: Full=Scavenger receptor class F member 1; AltName: Full=Acetyl LDL receptor; AltName: Full=Scavenger receptor expressed by endothelial cells 1; Short=SREC-I; Flags: Precursor [Homo sapiens]
GI:33598929 SwissProt Q14162.3 830 RecName: Full=Scavenger receptor class F member 1; AltName: Full=Acetyl LDL receptor; AltName: Full=Scavenger receptor expressed by endothelial cells 1; Short=SREC-I; Flags: Precursor [Homo sapiens]

Related Sequences to LMP006683 proteins

Reference Database Accession Length Protein Name
GI:33598929 DBBJ BAA24070.1 830 acetyl LDL receptor [Homo sapiens]
GI:33598929 DBBJ BAA24070.1 830 acetyl LDL receptor [Homo sapiens]
GI:33598929 DBBJ BAC02692.1 830 SREC [Homo sapiens]
GI:33598929 DBBJ BAC02692.1 830 SREC [Homo sapiens]
GI:33598929 GenBank EAW90598.1 830 scavenger receptor class F, member 1, isoform CRA_c [Homo sapiens]
GI:33598929 GenBank EAW90598.1 830 scavenger receptor class F, member 1, isoform CRA_c [Homo sapiens]
GI:33598929 GenBank ADA53379.1 830 Sequence 1209 from patent US 7625699
GI:33598929 GenBank ADA53379.1 830 Sequence 1209 from patent US 7625699
GI:33598929 GenBank ADS30921.1 830 Sequence 1453 from patent US 7781168
GI:33598929 GenBank ADS30921.1 830 Sequence 1453 from patent US 7781168
GI:33598929 GenBank ADS49389.1 830 Sequence 76 from patent US 7803637
GI:33598929 GenBank ADS49389.1 830 Sequence 76 from patent US 7803637