Gene/Proteome Database (LMPD)
LMPD ID
LMP006685
Gene ID
Species
Homo sapiens (Human)
Gene Name
acyl-CoA synthetase medium-chain family member 2B
Gene Symbol
Synonyms
ACSM2; HXMA
Alternate Names
acyl-coenzyme A synthetase ACSM2B, mitochondrial; butyrate--CoA ligase 2B; butyryl-coenzyme A synthetase 2B; middle-chain acyl-CoA synthetase 2B; xenobiotic/medium-chain fatty acid:CoA ligase; acyl-CoA synthetase medium-chain family member 2; xenobiotic/medium-chain fatty acid-CoA ligase HXM-A
Chromosome
16
Map Location
16p12.3
EC Number
6.2.1.2
Proteins
| acyl-coenzyme A synthetase ACSM2B, mitochondrial | |
|---|---|
| Refseq ID | NP_872423 |
| Protein GI | 157311622 |
| UniProt ID | Q68CK6 |
| mRNA ID | NM_182617 |
| Length | 577 |
| RefSeq Status | VALIDATED |
| MHWLRKVQGLCTLWGTQMSSRTLYINSRQLVSLQWGHQEVPAKFNFASDVLDHWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSENSQQAANILSGACGLQRGDRVAVMLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILNILGSLLESWTLGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCLAGGESLLPETLENWRAQTGLDIREFYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQVIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVENPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRADDIINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILASQFLSHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLRDKEWKMSGKARAQ | |
| transit_peptide: 1..46 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q68CK6.2) calculated_mol_wt: 5477 peptide sequence: MHWLRKVQGLCTLWGTQMSSRTLYINSRQLVSLQWGHQEVPAKFNF mat_peptide: 47..577 product: Acyl-coenzyme A synthetase ACSM2B, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q68CK6.2) calculated_mol_wt: 58812 peptide sequence: ASDVLDHWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSENSQQAANILSGACGLQRGDRVAVMLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILNILGSLLESWTLGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCLAGGESLLPETLENWRAQTGLDIREFYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQVIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVENPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRADDIINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILASQFLSHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLRDKEWKMSGKARAQ transit_peptide: 1..46 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q68CK6.2) calculated_mol_wt: 5477 peptide sequence: MHWLRKVQGLCTLWGTQMSSRTLYINSRQLVSLQWGHQEVPAKFNF mat_peptide: 47..577 product: Acyl-coenzyme A synthetase ACSM2B, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q68CK6.2) calculated_mol_wt: 58812 peptide sequence: ASDVLDHWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSENSQQAANILSGACGLQRGDRVAVMLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILNILGSLLESWTLGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCLAGGESLLPETLENWRAQTGLDIREFYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQVIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVENPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRADDIINSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVILASQFLSHDPEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRTKLRDKEWKMSGKARAQ | |
| acyl-coenzyme A synthetase ACSM2B, mitochondrial | |
|---|---|
| Refseq ID | NP_001098539 |
| Protein GI | 157311624 |
| UniProt ID | Q68CK6 |
| mRNA ID | NM_001105069 |
| Length | 577 |
| RefSeq Status | VALIDATED |
| Protein sequence is identical to GI:157311622 (mRNA isoform) | |
Gene Information
Entrez Gene ID
Gene Name
acyl-CoA synthetase medium-chain family member 2B
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005759 | TAS:Reactome | C | mitochondrial matrix |
| GO:0005739 | NAS:BHF-UCL | C | mitochondrion |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0047760 | IEA:UniProtKB-EC | F | butyrate-CoA ligase activity |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0006631 | IEA:UniProtKB-KW | P | fatty acid metabolic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0006805 | TAS:Reactome | P | xenobiotic metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa01100 | Metabolic pathways |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_6933 | Conjugation of benzoate with glycine |
| REACT_6800 | Conjugation of phenylacetate with glutamine |
| REACT_6812 | Conjugation of salicylate with glycine |
Domain Information
UniProt Annotations
Entry Information
Gene Name
acyl-CoA synthetase medium-chain family member 2B
Protein Entry
ACS2B_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA. |
| Cofactor | Name=Mg(2+); Xref=ChEBI |
| Enzyme Regulation | Activated by monovalent cations, such as potassium, rubidium or ammonium. |
| Function | Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). |
| Similarity | Belongs to the ATP-dependent AMP-binding enzyme family. |
| Subcellular Location | Mitochondrion matrix {ECO |
| Subunit | Monomer. |
| Tissue Specificity | Detected in liver. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006685 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 157311622 | RefSeq | NP_872423 | 577 | acyl-coenzyme A synthetase ACSM2B, mitochondrial |
Identical Sequences to LMP006685 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:157311622 | GenBank | AAI72335.1 | 577 | Acyl-CoA synthetase medium-chain family member 2B [synthetic construct] |
| GI:157311622 | RefSeq | NP_001098539.1 | 577 | acyl-coenzyme A synthetase ACSM2B, mitochondrial [Homo sapiens] |
| GI:157311622 | SwissProt | Q68CK6.2 | 577 | RecName: Full=Acyl-coenzyme A synthetase ACSM2B, mitochondrial; AltName: Full=Acyl-CoA synthetase medium-chain family member 2B; AltName: Full=Butyrate--CoA ligase 2B; AltName: Full=Butyryl-coenzyme A synthetase 2B; AltName: Full=Middle-chain acyl-CoA synthetase 2B; AltName: Full=Xenobiotic/medium-chain fatty acid-CoA ligase HXM-A; Flags: Precursor [Homo sapiens] |
Related Sequences to LMP006685 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:157311622 | DBBJ | BAD38642.1 | 577 | putative protein product of HYST1046 [Homo sapiens] |
| GI:157311622 | DBBJ | BAF82105.1 | 577 | unnamed protein product [Homo sapiens] |
| GI:157311622 | GenBank | ADA19222.1 | 577 | Sequence 1046 from patent US 7608413 |
| GI:157311622 | GenBank | ADA19223.1 | 577 | Sequence 1047 from patent US 7608413 |
| GI:157311622 | GenBank | AEN35119.1 | 577 | Sequence 1047 from patent US 7998689 |
| GI:157311622 | GenBank | AHD74849.1 | 577 | Sequence 15553 from patent US 8586006 |