Gene/Proteome Database (LMPD)

LMPD ID
LMP006686
Gene ID
22845
Species
Homo sapiens (Human)
Gene Name
dolichol kinase
Gene Symbol
DOLK
Synonyms
CDG1M; DK; DK1; SEC59; TMEM15
Alternate Names
dolichol kinase; SEC59 homolog; dolichol kinase 1; transmembrane protein 15
Chromosome
9
Map Location
9q34.11
EC Number
2.7.1.108
Summary
The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010]
Orthologs
View orthologs and multiple alignments for DOLK

Proteins

dolichol kinase
Refseq ID NP_055723
Protein GI 7662482
UniProt ID Q9UPQ8
mRNA ID NM_014908
Length 538
RefSeq Status REVIEWED
MTRECPSPAPGPGAPLSGSVLAEAAVVFAVVLSIHATVWDRYSWCAVALAVQAFYVQYKWDRLLQQGSAVFQFRMSANSGLLPASMVMPLLGLVMKERCQTAGNPFFERFGIVVAATGMAVALFSSVLALGITRPVPTNTCVILGLAGGVIIYIMKHSLSVGEVIEVLEVLLIFVYLNMILLYLLPRCFTPGEALLVLGGISFVLNQLIKRSLTLVESQGDPVDFFLLVVVVGMVLMGIFFSTLFVFMDSGTWASSIFFHLMTCVLSLGVVLPWLHRLIRRNPLLWLLQFLFQTDTRIYLLAYWSLLATLACLVVLYQNAKRSSSESKKHQAPTIARKYFHLIVVATYIPGIIFDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSFLSLFLDERDSGPLILTHIYLLLGMSLPIWLIPRPCTQKGSLGGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALILIFDSGVDLNYSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA

Gene Information

Entrez Gene ID
22845
Gene Name
dolichol kinase
Gene Symbol
DOLK
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0030176 IDA:UniProtKB C integral component of endoplasmic reticulum membrane
GO:0004168 IDA:UniProtKB F dolichol kinase activity
GO:0044267 TAS:Reactome P cellular protein metabolic process
GO:0006488 TAS:Reactome P dolichol-linked oligosaccharide biosynthetic process
GO:0006489 TAS:Reactome P dolichyl diphosphate biosynthetic process
GO:0043048 IDA:UniProtKB P dolichyl monophosphate biosynthetic process
GO:0043687 TAS:Reactome P post-translational protein modification
GO:0018279 TAS:Reactome P protein N-linked glycosylation via asparagine

KEGG Pathway Links

KEGG Pathway ID Description
hsa01100 Metabolic pathways
hsa00510 N-Glycan biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_22230 Synthesis of Dolichyl-phosphate
REACT_22387 Synthesis of substrates in N-glycan biosythesis

Domain Information

InterPro Annotations

Accession Description
IPR026566 Dolichol kinase

UniProt Annotations

Entry Information

Gene Name
dolichol kinase
Protein Entry
DOLK_HUMAN
UniProt ID
Q9UPQ8
Species
Human

Comments

Comment Type Description
Catalytic Activity CTP + dolichol = CDP + dolichyl phosphate.
Disease Congenital disorder of glycosylation 1M (CDG1M) [MIM
Function Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors.
Miscellaneous Complements the defects in growth, dolichol kinase activity and protein N-glycosylation at the restrictive temperature in yeast sec59 mutant cells.
Sequence Caution Sequence=BAA83046.2; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the polyprenol kinase family.
Subcellular Location Endoplasmic reticulum membrane {ECO
Tissue Specificity Ubiquitous.

Identical and Related Proteins

Unique RefSeq proteins for LMP006686 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7662482 RefSeq NP_055723 538 dolichol kinase

Identical Sequences to LMP006686 proteins

Reference Database Accession Length Protein Name
GI:7662482 GenBank ADS45535.1 538 Sequence 50 from patent US 7795412
GI:7662482 GenBank ADZ15912.1 538 dolichol kinase, partial [synthetic construct]
GI:7662482 GenBank JAA06824.1 538 dolichol kinase [Pan troglodytes]
GI:7662482 GenBank JAA25321.1 538 dolichol kinase [Pan troglodytes]
GI:7662482 GenBank JAA37232.1 538 dolichol kinase [Pan troglodytes]
GI:7662482 RefSeq XP_008974155.1 538 PREDICTED: dolichol kinase [Pan paniscus]

Related Sequences to LMP006686 proteins

Reference Database Accession Length Protein Name
GI:7662482 DBBJ BAA83046.2 544 KIAA1094 protein, partial [Homo sapiens]
GI:7662482 GenBank ABY56110.1 538 dolichol kinase (predicted) [Papio anubis]
GI:7662482 GenBank EHH23758.1 538 hypothetical protein EGK_07298 [Macaca mulatta]
GI:7662482 GenBank EHH57059.1 538 hypothetical protein EGM_06620 [Macaca fascicularis]
GI:7662482 RefSeq XP_003264273.1 538 PREDICTED: dolichol kinase [Nomascus leucogenys]
GI:7662482 RefSeq XP_004048758.1 538 PREDICTED: dolichol kinase [Gorilla gorilla gorilla]