Gene/Proteome Database (LMPD)

LMPD ID
LMP006687
Gene ID
6653
Species
Homo sapiens (Human)
Gene Name
sortilin-related receptor, L(DLR class) A repeats containing
Gene Symbol
SORL1
Synonyms
C11orf32; LR11; LRP9; SORLA; SorLA-1; gp250
Alternate Names
sortilin-related receptor; mosaic protein LR11; LDLR relative with 11 ligand-binding repeats; sortilin-related receptor, L(DLR class) A repeats-containing; sorting protein-related receptor containing LDLR class A repeats; low-density lipoprotein receptor relative with 11 ligand-binding repeats
Chromosome
11
Map Location
11q23.2-q24.2
Summary
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.[provided by RefSeq, Sep 2010]
Orthologs
View orthologs and multiple alignments for SORL1

Proteins

sortilin-related receptor preproprotein
Refseq ID NP_003096
Protein GI 4507157
UniProt ID Q92673
mRNA ID NM_003105
Length 2214
RefSeq Status REVIEWED
MATRSSRRESRLPFLFTLVALLPPGALCEVWTQRLHGGSAPLPQDRGFLVVQGDPRELRLWARGDARGASRADEKPLRRKRSAALQPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFADAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVFVCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGKSYSPPVPCPVGSTYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDDQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETHSNKTNTVLKVLKPDTTYQVKVQVQCLSKAHNTNDFVTLRTPEGLPDAPRNLQLSLPREAEGVIVGHWAPPIHTHGLIREYIVEYSRSGSKMWASQRAASNFTEIKNLLVNTLYTVRVAAVTSRGIGNWSDSKSITTIKGKVIPPPDIHIDSYGENYLSFTLTMESDIKVNGYVVNLFWAFDTHKQERRTLNFRGSILSHKVGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAPSLKAKAINQTAVECTWTGPRNVVYGIFYATSFLDLYRNPKSLTTSLHNKTVIVSKDEQYLFLVRVVVPYQGPSSDYVVVKMIPDSRLPPRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAIAVKDLIRKTDRSYKVKSRNSTVEYTLNKLEPGGKYHIIVQLGNMSKDSSIKITTVSLSAPDALKIITENDHVLLFWKSLALKEKHFNESRGYEIHMFDSAMNITAYLGNTTDNFFKISNLKMGHNYTFTVQARCLFGNQICGEPAILLYDELGSGADASATQAARSTDVAAVVVPILFLILLSLGVGFAILYTKHRRLQSSFTAFANSHYSSRLGSAIFSSGDDLGEDDEDAPMITGFSDDVPMVIA
sig_peptide: 1..28 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3104 peptide sequence: MATRSSRRESRLPFLFTLVALLPPGALC mat_peptide: 82..2214 product: sortilin-related receptor calculated_mol_wt: 239312 peptide sequence: SAALQPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFADAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVFVCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGKSYSPPVPCPVGSTYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDDQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETHSNKTNTVLKVLKPDTTYQVKVQVQCLSKAHNTNDFVTLRTPEGLPDAPRNLQLSLPREAEGVIVGHWAPPIHTHGLIREYIVEYSRSGSKMWASQRAASNFTEIKNLLVNTLYTVRVAAVTSRGIGNWSDSKSITTIKGKVIPPPDIHIDSYGENYLSFTLTMESDIKVNGYVVNLFWAFDTHKQERRTLNFRGSILSHKVGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAPSLKAKAINQTAVECTWTGPRNVVYGIFYATSFLDLYRNPKSLTTSLHNKTVIVSKDEQYLFLVRVVVPYQGPSSDYVVVKMIPDSRLPPRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAIAVKDLIRKTDRSYKVKSRNSTVEYTLNKLEPGGKYHIIVQLGNMSKDSSIKITTVSLSAPDALKIITENDHVLLFWKSLALKEKHFNESRGYEIHMFDSAMNITAYLGNTTDNFFKISNLKMGHNYTFTVQARCLFGNQICGEPAILLYDELGSGADASATQAARSTDVAAVVVPILFLILLSLGVGFAILYTKHRRLQSSFTAFANSHYSSRLGSAIFSSGDDLGEDDEDAPMITGFSDDVPMVIA

Gene Information

Entrez Gene ID
6653
Gene Name
sortilin-related receptor, L(DLR class) A repeats containing
Gene Symbol
SORL1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005769 IDA:Alzheimers_University_of_Toronto C early endosome
GO:0005783 IDA:Alzheimers_University_of_Toronto C endoplasmic reticulum
GO:0005768 IDA:UniProtKB C endosome
GO:0005615 IDA:UniProtKB C extracellular space
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0005794 IDA:UniProtKB C Golgi apparatus
GO:0031985 IDA:Alzheimers_University_of_Toronto C Golgi cisterna
GO:0005887 TAS:ProtInc C integral component of plasma membrane
GO:0034362 IEA:UniProtKB-KW C low-density lipoprotein particle
GO:0016020 IDA:UniProtKB C membrane
GO:0005771 IEA:Ensembl C multivesicular body
GO:0043025 IEA:Ensembl C neuronal cell body
GO:0005641 IDA:Alzheimers_University_of_Toronto C nuclear envelope lumen
GO:0055037 IMP:Alzheimers_University_of_Toronto C recycling endosome
GO:0005802 IDA:Alzheimers_University_of_Toronto C trans-Golgi network
GO:0030306 IPI:Alzheimers_University_of_Toronto F ADP-ribosylation factor binding
GO:0001540 IDA:Alzheimers_University_of_Toronto F beta-amyloid binding
GO:0030169 IPI:BHF-UCL F low-density lipoprotein particle binding
GO:0004888 TAS:ProtInc F transmembrane signaling receptor activity
GO:0008219 IEA:UniProtKB-KW P cell death
GO:0016477 IEA:Ensembl P cell migration
GO:0008283 IEA:Ensembl P cell proliferation
GO:0008203 IEA:UniProtKB-KW P cholesterol metabolic process
GO:0006869 IEA:UniProtKB-KW P lipid transport
GO:1902960 IDA:Alzheimers_University_of_Toronto P negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902430 IDA:Alzheimers_University_of_Toronto P negative regulation of beta-amyloid formation
GO:0043407 ISS:Alzheimers_University_of_Toronto P negative regulation of MAP kinase activity
GO:1902963 IMP:Alzheimers_University_of_Toronto P negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902997 ISS:Alzheimers_University_of_Toronto P negative regulation of neurofibrillary tangle assembly
GO:0050768 ISS:Alzheimers_University_of_Toronto P negative regulation of neurogenesis
GO:1901215 ISS:Alzheimers_University_of_Toronto P negative regulation of neuron death
GO:0032091 IDA:Alzheimers_University_of_Toronto P negative regulation of protein binding
GO:0032460 IMP:Alzheimers_University_of_Toronto P negative regulation of protein oligomerization
GO:1902948 ISS:Alzheimers_University_of_Toronto P negative regulation of tau-protein kinase activity
GO:1902771 ISS:Alzheimers_University_of_Toronto P positive regulation of choline O-acetyltransferase activity
GO:1902955 IMP:Alzheimers_University_of_Toronto P positive regulation of early endosome to recycling endosome transport
GO:2001137 IMP:Alzheimers_University_of_Toronto P positive regulation of endocytic recycling
GO:1902953 IMP:Alzheimers_University_of_Toronto P positive regulation of ER to Golgi vesicle-mediated transport
GO:0045732 IDA:Alzheimers_University_of_Toronto P positive regulation of protein catabolic process
GO:0070863 IMP:Alzheimers_University_of_Toronto P positive regulation of protein exit from endoplasmic reticulum
GO:1902966 IMP:Alzheimers_University_of_Toronto P positive regulation of protein localization to early endosome
GO:0006892 IDA:Alzheimers_University_of_Toronto P post-Golgi vesicle-mediated transport
GO:0051604 IDA:Alzheimers_University_of_Toronto P protein maturation
GO:0045053 IDA:Alzheimers_University_of_Toronto P protein retention in Golgi apparatus
GO:0006605 IMP:UniProtKB P protein targeting
GO:0000042 IDA:Alzheimers_University_of_Toronto P protein targeting to Golgi
GO:0006622 IDA:Alzheimers_University_of_Toronto P protein targeting to lysosome
GO:0006898 TAS:ProtInc P receptor-mediated endocytosis
GO:0014910 IDA:UniProtKB P regulation of smooth muscle cell migration
GO:0007165 TAS:GOC P signal transduction

Domain Information

InterPro Annotations

Accession Description
IPR000742 Epidermal growth factor-like domain
IPR003961 Fibronectin type III
IPR013783 Immunoglobulin-like fold
IPR000033 LDLR class B repeat
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR011042 Six-bladed beta-propeller, TolB-like
IPR006581 VPS10

UniProt Annotations

Entry Information

Gene Name
sortilin-related receptor, L(DLR class) A repeats containing
Protein Entry
SORL_HUMAN
UniProt ID
Q92673
Species
Human

Comments

Comment Type Description
Disease Alzheimer disease (AD) [MIM
Function Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization. {ECO
Ptm The propeptide removed in the N-terminus may be cleaved by furin or homologous proteases.
Similarity Belongs to the VPS10-related sortilin family. SORL1 subfamily.
Similarity Contains 11 LDL-receptor class A domains.
Similarity Contains 1 EGF-like domain.
Similarity Contains 5 BNR repeats.
Similarity Contains 5 LDL-receptor class B repeats.
Similarity Contains 6 fibronectin type-III domains.
Subcellular Location Membrane ; Single-pass type I membrane protein . Golgi apparatus. Endosome. Secreted.
Subunit Interacts with GGA1 and ROCK2. Interacts with PLAUR. Interacts with APP. {ECO
Tissue Specificity Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. Expression is significantly reduced in the frontal cortex of patients suffering from Alzheimer disease. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.

Identical and Related Proteins

Unique RefSeq proteins for LMP006687 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4507157 RefSeq NP_003096 2214 sortilin-related receptor preproprotein

Identical Sequences to LMP006687 proteins

Reference Database Accession Length Protein Name
GI:4507157 GenBank AEU55858.1 2214 Sequence 2 from patent US 8066997
GI:4507157 GenBank AFL31428.1 2214 Sequence 89 from patent US 8173125
GI:4507157 GenBank AGA41989.1 2214 Sequence 94 from patent US 8323906
GI:4507157 GenBank AGM72532.1 2214 Sequence 2 from patent US 8377701
GI:4507157 GenBank AGP15288.1 2214 Sequence 2 from patent US 8460657
GI:4507157 GenBank AGU27937.1 2214 Sequence 27 from patent US 8497078

Related Sequences to LMP006687 proteins

Reference Database Accession Length Protein Name
GI:4507157 GenBank JAB31583.1 2214 sortilin-related receptor preproprotein [Callithrix jacchus]
GI:4507157 RefSeq XP_003820019.1 2214 PREDICTED: sortilin-related receptor [Pan paniscus]
GI:4507157 RefSeq XP_003910898.1 2214 PREDICTED: sortilin-related receptor isoform X1 [Papio anubis]
GI:4507157 RefSeq XP_004052349.1 2218 PREDICTED: sortilin-related receptor [Gorilla gorilla gorilla]
GI:4507157 RefSeq XP_008019432.1 2214 PREDICTED: sortilin-related receptor [Chlorocebus sabaeus]
GI:4507157 SwissProt Q92673.2 2214 RecName: Full=Sortilin-related receptor; AltName: Full=Low-density lipoprotein receptor relative with 11 ligand-binding repeats; Short=LDLR relative with 11 ligand-binding repeats; Short=LR11; AltName: Full=SorLA-1; AltName: Full=Sorting protein-related receptor containing LDLR class A repeats; Short=SorLA; Flags: Precursor [Homo sapiens]