Gene/Proteome Database (LMPD)

LMPD ID
LMP006695
Gene ID
23673
Species
Homo sapiens (Human)
Gene Name
syntaxin 12
Gene Symbol
STX12
Synonyms
STX13; STX14
Alternate Names
syntaxin-12
Chromosome
1
Map Location
1p35.3

Proteins

syntaxin-12
Refseq ID NP_803173
Protein GI 28933465
UniProt ID Q86Y82
mRNA ID NM_177424
Length 276
RefSeq Status VALIDATED
MSYGPLDMYRNPGPSGPQLRDFSSIIQTCSGNIQRISQATAQIKNLMSQLGTKQDSSKLQENLQQLQHSTNQLAKETNELLKELGSLPLPLSTSEQRQQRLQKERLMNDFSAALNNFQAVQRRVSEKEKESIARARAGSRLSAEERQREEQLVSFDSHEEWNQMQSQEDEVAITEQDLELIKERETAIRQLEADILDVNQIFKDLAMMIHDQGDLIDSIEANVESSEVHVERATEQLQRAAYYQKKSRKKMCILVLVLSVIILILGLIIWLVYKTK

Gene Information

Entrez Gene ID
23673
Gene Name
syntaxin 12
Gene Symbol
STX12
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0031201 IDA:UniProtKB C SNARE complex
GO:0005768 IEA:UniProtKB-KW C endosome
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0045121 IDA:BHF-UCL C membrane raft
GO:0045335 IDA:BHF-UCL C phagocytic vesicle
GO:0005484 IBA:RefGenome F SNAP receptor activity
GO:0000149 IBA:RefGenome F SNARE binding
GO:0033344 IDA:BHF-UCL P cholesterol efflux
GO:0006886 IBA:RefGenome P intracellular protein transport
GO:0050821 IDA:BHF-UCL P protein stabilization
GO:0016079 IBA:RefGenome P synaptic vesicle exocytosis

KEGG Pathway Links

KEGG Pathway ID Description
hsa04145 Phagosome
ko04145 Phagosome

Domain Information

InterPro Annotations

Accession Description
IPR006011 Syntaxin, N-terminal domain
IPR006012 Syntaxin/epimorphin, conserved site
IPR000727 Target SNARE coiled-coil domain
IPR010989 t-SNARE

UniProt Annotations

Entry Information

Gene Name
syntaxin 12
Protein Entry
STX12_HUMAN
UniProt ID
Q86Y82
Species
Human

Comments

Comment Type Description
Function SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity).
Interaction O95477:ABCA1; NbExp=9; IntAct=EBI-2691717, EBI-784112;
Sequence Caution Sequence=CAA22911.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Similarity Belongs to the syntaxin family.
Similarity Contains 1 t-SNARE coiled-coil homology domain.
Subcellular Location Endosome membrane ; Single-pass type IV membrane protein . Golgi apparatus membrane {ECO
Subunit Interacts with NAPA and SNAP23. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By similarity). Associates with the BLOC-1 complex. Interacts with BLOC1S6.

Identical and Related Proteins

Unique RefSeq proteins for LMP006695 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
28933465 RefSeq NP_803173 276 syntaxin-12

Identical Sequences to LMP006695 proteins

Reference Database Accession Length Protein Name
GI:28933465 GenBank JAA33007.1 276 syntaxin 12 [Pan troglodytes]
GI:28933465 GenBank JAA33008.1 276 syntaxin 12 [Pan troglodytes]
GI:28933465 GenBank JAA41783.1 276 syntaxin 12 [Pan troglodytes]
GI:28933465 GenBank JAA41784.1 276 syntaxin 12 [Pan troglodytes]
GI:28933465 GenBank AHD71138.1 276 Sequence 4606 from patent US 8586006
GI:28933465 GenBank AIC51019.1 276 STX12, partial [synthetic construct]

Related Sequences to LMP006695 proteins

Reference Database Accession Length Protein Name
GI:28933465 GenBank AAE43163.1 319 Sequence 1 from patent US 6074844
GI:28933465 RefSeq XP_003271731.1 276 PREDICTED: syntaxin-12 [Nomascus leucogenys]
GI:28933465 RefSeq XP_003891475.1 276 PREDICTED: syntaxin-12 isoform X1 [Papio anubis]
GI:28933465 RefSeq XP_003921331.1 276 PREDICTED: syntaxin-12 [Saimiri boliviensis boliviensis]
GI:28933465 RefSeq XP_007978000.1 276 PREDICTED: syntaxin-12 [Chlorocebus sabaeus]
GI:28933465 RefSeq XP_010378669.1 276 PREDICTED: syntaxin-12 [Rhinopithecus roxellana]