Gene/Proteome Database (LMPD)

LMPD ID
LMP006701
Gene ID
57580
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Gene Symbol
PREX1
Synonyms
P-REX1
Alternate Names
phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; ptdIns(3,4,5)-dependent Rac exchanger 1
Chromosome
20
Map Location
20q13.13
Summary
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for PREX1

Proteins

phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Refseq ID NP_065871
Protein GI 34452732
UniProt ID Q8TCU6
mRNA ID NM_020820
Length 1659
RefSeq Status REVIEWED
MEAPSGSEPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVAGLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRGAAPPYVYAVGRGSEAMAAGLCAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREEALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSPMVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMPHFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQHCITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLLSTITEPTSGGSCDASLAEEASSLPLVSEESEMDRSDHGGIKKVCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGSGDELPCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEFKQKEECTIRGRSLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAIFCQALVAAVCTFSEQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHCQSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASLRLHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEKVQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSVGAGLIPISSELCYRLGACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNLRVKDQMPQGAPRLYRLCQPPVDGDL

Gene Information

Entrez Gene ID
57580
Gene Name
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Gene Symbol
PREX1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:HPA C cytoplasm
GO:0005829 IDA:UniProtKB C cytosol
GO:0043198 IEA:Ensembl C dendritic shaft
GO:0030426 IEA:Ensembl C growth cone
GO:0043231 IDA:HPA C intracellular membrane-bounded organelle
GO:0048471 IEA:Ensembl C perinuclear region of cytoplasm
GO:0005886 TAS:UniProtKB C plasma membrane
GO:0019899 TAS:UniProtKB F enzyme binding
GO:0005543 IDA:UniProtKB F phospholipid binding
GO:0005100 TAS:UniProtKB F Rho GTPase activator activity
GO:0005089 TAS:UniProtKB F Rho guanyl-nucleotide exchange factor activity
GO:0030041 TAS:UniProtKB P actin filament polymerization
GO:0007186 IEA:Ensembl P G-protein coupled receptor signaling pathway
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0042119 TAS:UniProtKB P neutrophil activation
GO:0030593 IEA:Ensembl P neutrophil chemotaxis
GO:0032855 IEA:Ensembl P positive regulation of Rac GTPase activity
GO:1900026 IEA:Ensembl P positive regulation of substrate adhesion-dependent cell spreading
GO:0030833 IEA:Ensembl P regulation of actin filament polymerization
GO:0050773 IEA:Ensembl P regulation of dendrite development
GO:0006801 TAS:UniProtKB P superoxide metabolic process
GO:0030217 IEA:Ensembl P T cell differentiation

KEGG Pathway Links

KEGG Pathway ID Description
hsa04062 Chemokine signaling pathway
ko04062 Chemokine signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR000219 Dbl homology (DH) domain
IPR000591 DEP domain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
IPR001478 PDZ domain
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain
IPR011991 Winged helix-turn-helix DNA-binding domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Protein Entry
PREX1_HUMAN
UniProt ID
Q8TCU6
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8TCU6-1; Sequence=Displayed; Name=2; IsoId=Q8TCU6-2; Sequence=VSP_001818, VSP_001819; Name=3; IsoId=Q8TCU6-3; Sequence=VSP_015090, VSP_015091; Note=Gene prediction based on EST data. No experimental confirmation available.;
Function Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Interaction P31750:Akt1 (xeno); NbExp=2; IntAct=EBI-1046542, EBI-298707; P42345:MTOR; NbExp=11; IntAct=EBI-1046542, EBI-359260; Q6R327:RICTOR; NbExp=3; IntAct=EBI-1046542, EBI-1387196; Q8N122:RPTOR; NbExp=2; IntAct=EBI-1046542, EBI-1567928;
Similarity Contains 1 DH (DBL-homology) domain.
Similarity Contains 1 PDZ (DHR) domain. {ECO
Similarity Contains 1 PH domain. {ECO
Similarity Contains 2 DEP domains. {ECO
Subcellular Location Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane.
Subunit Interacts preferentially with RAC2 (By similarity). Interacts with RAC1.
Tissue Specificity Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.

Identical and Related Proteins

Unique RefSeq proteins for LMP006701 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
34452732 RefSeq NP_065871 1659 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Identical Sequences to LMP006701 proteins

Reference Database Accession Length Protein Name
GI:34452732 GenBank EAW75684.1 1659 phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 1, isoform CRA_a [Homo sapiens]
GI:34452732 GenBank EAW75685.1 1659 phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 1, isoform CRA_a [Homo sapiens]
GI:34452732 GenBank AAI56403.1 1659 Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1, partial [synthetic construct]
GI:34452732 GenBank ACP87563.1 1659 Sequence 205 from patent US 7504211
GI:34452732 GenBank ACS08240.1 1659 Sequence 205 from patent US 7537891
GI:34452732 GenBank AHD71834.1 1659 Sequence 6528 from patent US 8586006

Related Sequences to LMP006701 proteins

Reference Database Accession Length Protein Name
GI:34452732 EMBL CAC86401.1 1659 P-Rex1 protein [Homo sapiens]
GI:34452732 GenBank JAA10879.1 1659 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 [Pan troglodytes]
GI:34452732 GenBank JAA30612.1 1659 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 [Pan troglodytes]
GI:34452732 GenBank JAA38741.1 1659 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 [Pan troglodytes]
GI:34452732 RefSeq XP_008012826.1 1661 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X2 [Chlorocebus sabaeus]
GI:34452732 SwissProt Q8TCU6.3 1659 RecName: Full=Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; Short=P-Rex1; Short=PtdIns(3,4,5)-dependent Rac exchanger 1 [Homo sapiens]