Gene/Proteome Database (LMPD)

LMPD ID
LMP006702
Gene ID
1559
Species
Homo sapiens (Human)
Gene Name
cytochrome P450, family 2, subfamily C, polypeptide 9
Gene Symbol
CYP2C9
Synonyms
CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9
Alternate Names
cytochrome P450 2C9; cytochrome P-450MP; cytochrome P450 PB-1; microsomal monooxygenase; xenobiotic monooxygenase; flavoprotein-linked monooxygenase; cytochrome P-450 S-mephenytoin 4-hydroxylase
Chromosome
10
Map Location
10q24
EC Number
1.14.13.-
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for CYP2C9

Proteins

cytochrome P450 2C9 precursor
Refseq ID NP_000762
Protein GI 13699818
UniProt ID P11712
mRNA ID NM_000771
Length 490
RefSeq Status REVIEWED
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV
sig_peptide: 1..25 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2749 peptide sequence: MDSLVVLVLCLSCLLLLSLWRQSSG

Gene Information

Entrez Gene ID
1559
Gene Name
cytochrome P450, family 2, subfamily C, polypeptide 9
Gene Symbol
CYP2C9
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0043231 IDA:UniProtKB C intracellular membrane-bounded organelle
GO:0052741 IEA:UniProtKB-EC F (R)-limonene 6-monooxygenase activity
GO:0018675 IEA:UniProtKB-EC F (S)-limonene 6-monooxygenase activity
GO:0018676 IEA:UniProtKB-EC F (S)-limonene 7-monooxygenase activity
GO:0034875 IDA:BHF-UCL F caffeine oxidase activity
GO:0008144 IDA:BHF-UCL F drug binding
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004497 NAS:UniProtKB F monooxygenase activity
GO:0016491 IDA:BHF-UCL F oxidoreductase activity
GO:0008395 IMP:BHF-UCL F steroid hydroxylase activity
GO:0019369 TAS:Reactome P arachidonic acid metabolic process
GO:0043603 IDA:BHF-UCL P cellular amide metabolic process
GO:0042737 IMP:BHF-UCL P drug catabolic process
GO:0017144 IMP:UniProtKB P drug metabolic process
GO:0019373 TAS:Reactome P epoxygenase P450 pathway
GO:0042738 IDA:BHF-UCL P exogenous drug catabolic process
GO:0032787 IDA:BHF-UCL P monocarboxylic acid metabolic process
GO:0016098 IDA:BHF-UCL P monoterpenoid metabolic process
GO:0097267 TAS:Reactome P omega-hydroxylase P450 pathway
GO:0055114 IDA:BHF-UCL P oxidation-reduction process
GO:0070989 IDA:BHF-UCL P oxidative demethylation
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0008202 IMP:BHF-UCL P steroid metabolic process
GO:0019627 IDA:BHF-UCL P urea metabolic process
GO:0006805 TAS:Reactome P xenobiotic metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa05204 Chemical carcinogenesis
hsa04726 Serotonergic synapse

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 2, subfamily C, polypeptide 9
Protein Entry
CP2C9_HUMAN
UniProt ID
P11712
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11712-1; Sequence=Displayed; Name=2; IsoId=P11712-2; Sequence=VSP_055573, VSP_055574; Note=No experimental confirmation available.;
Catalytic Activity (+)-(R)-limonene + NADPH + O(2) = (+)-trans- carveol + NADP(+) + H(2)O.
Catalytic Activity (-)-(S)-limonene + NADPH + O(2) = (-)-perillyl alcohol + NADP(+) + H(2)O.
Catalytic Activity (-)-(S)-limonene + NADPH + O(2) = (-)-trans- carveol + NADP(+) + H(2)O.
Cofactor Name=heme; Xref=ChEBI
Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S- warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Induction By rifampicin.
Similarity Belongs to the cytochrome P450 family.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Web Resource Name=Cytochrome P450 Allele Nomenclature Committee; Note=CYP2C9 alleles; URL="http://www.cypalleles.ki.se/cyp2c9.htm";
Web Resource Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cyp2c9/";

Identical and Related Proteins

Unique RefSeq proteins for LMP006702 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13699818 RefSeq NP_000762 490 cytochrome P450 2C9 precursor

Identical Sequences to LMP006702 proteins

Reference Database Accession Length Protein Name
GI:13699818 GenBank AGS09761.1 490 cytochrome P450 family 2 subfamily C polypeptide 9 [Homo sapiens]
GI:13699818 GenBank AGS09762.1 490 cytochrome P450 family 2 subfamily C polypeptide 9 [Homo sapiens]
GI:13699818 GenBank AGS09763.1 490 cytochrome P450 family 2 subfamily C polypeptide 9 [Homo sapiens]
GI:13699818 GenBank AGS09764.1 490 cytochrome P450 family 2 subfamily C polypeptide 9 [Homo sapiens]
GI:13699818 GenBank AHD77998.1 490 Sequence 24977 from patent US 8586006
GI:13699818 GenBank AIC48605.1 490 CYP2C9, partial [synthetic construct]

Related Sequences to LMP006702 proteins

Reference Database Accession Length Protein Name
GI:13699818 GenBank AGS09719.1 490 cytochrome P450 family 2 subfamily C polypeptide 9 [Homo sapiens]
GI:13699818 GenBank AGS09726.1 490 cytochrome P450 family 2 subfamily C polypeptide 9 [Homo sapiens]
GI:13699818 GenBank AGS09729.1 490 cytochrome P450 family 2 subfamily C polypeptide 9 [Homo sapiens]
GI:13699818 GenBank AGS09734.1 490 cytochrome P450 family 2 subfamily C polypeptide 9 [Homo sapiens]
GI:13699818 GenBank AGS09735.1 490 cytochrome P450 family 2 subfamily C polypeptide 9 [Homo sapiens]
GI:13699818 GenBank AGS09737.1 490 cytochrome P450 family 2 subfamily C polypeptide 9 [Homo sapiens]