Gene/Proteome Database (LMPD)
LMPD ID
LMP006704
Gene ID
Species
Homo sapiens (Human)
Gene Name
lipase, family member K
Gene Symbol
Synonyms
LIPL2; bA186O14.2
Alternate Names
lipase member K; lipase K; lipase-like, ab-hydrolase domain containing 2; lipase-like abhydrolase domain-containing protein 2
Chromosome
10
Map Location
10q23.31
EC Number
3.1.1.-
Proteins
| lipase member K precursor | |
|---|---|
| Refseq ID | NP_001073987 |
| Protein GI | 122937476 |
| UniProt ID | Q5VXJ0 |
| mRNA ID | NM_001080518 |
| Length | 399 |
| RefSeq Status | PROVISIONAL |
| MWQLLAAACWMLLLGSMYGYDKKGNNANPEANMNISQIISYWGYPYEEYDVTTKDGYILGIYRIPHGRGCPGRTAPKPAVYLQHGLIASASNWICNLPNNSLAFLLADSGYDVWLGNSRGNTWSRKHLKLSPKSPEYWAFSLDEMAKYDLPATINFIIEKTGQKRLYYVGHSQGTTIAFIAFSTNPELAKKIKIFFALAPVVTVKYTQSPMKKLTTLSRRVVKVLFGDKMFHPHTLFDQFIATKVCNRKLFRRICSNFLFTLSGFDPQNLNMSRLDVYLSHNPAGTSVQNMLHWAQAVNSGQLQAFDWGNSDQNMMHFHQLTPPLYNITKMEVPTAIWNGGQDIVADPKDVENLLPQIANLIYYKLIPHYNHVDFYLGEDAPQEIYQDLIILMEEYLQN | |
| sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2159 peptide sequence: MWQLLAAACWMLLLGSMYG mat_peptide: 20..399 product: Lipase member K experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q5VXJ0.2) calculated_mol_wt: 43423 peptide sequence: YDKKGNNANPEANMNISQIISYWGYPYEEYDVTTKDGYILGIYRIPHGRGCPGRTAPKPAVYLQHGLIASASNWICNLPNNSLAFLLADSGYDVWLGNSRGNTWSRKHLKLSPKSPEYWAFSLDEMAKYDLPATINFIIEKTGQKRLYYVGHSQGTTIAFIAFSTNPELAKKIKIFFALAPVVTVKYTQSPMKKLTTLSRRVVKVLFGDKMFHPHTLFDQFIATKVCNRKLFRRICSNFLFTLSGFDPQNLNMSRLDVYLSHNPAGTSVQNMLHWAQAVNSGQLQAFDWGNSDQNMMHFHQLTPPLYNITKMEVPTAIWNGGQDIVADPKDVENLLPQIANLIYYKLIPHYNHVDFYLGEDAPQEIYQDLIILMEEYLQN | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005576 | IEA:UniProtKB-KW | C | extracellular region |
| GO:0016788 | IEA:InterPro | F | hydrolase activity, acting on ester bonds |
| GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Function | Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers. |
| Similarity | Belongs to the AB hydrolase superfamily. Lipase family. |
| Subcellular Location | Secreted . |
| Tissue Specificity | Exclusively expressed in the epidermis within the granular keratinocytes. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006704 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 122937476 | RefSeq | NP_001073987 | 399 | lipase member K precursor |
Identical Sequences to LMP006704 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:122937476 | DBBJ | BAI46954.1 | 399 | lipase, family member K, partial [synthetic construct] |
| GI:122937476 | GenBank | ABR08387.1 | 399 | lipase K [Homo sapiens] |
| GI:122937476 | GenBank | AAI52925.1 | 399 | Lipase, family member K, partial [synthetic construct] |
| GI:122937476 | SwissProt | Q5VXJ0.2 | 399 | RecName: Full=Lipase member K; AltName: Full=Lipase-like abhydrolase domain-containing protein 2; Flags: Precursor [Homo sapiens] |
Related Sequences to LMP006704 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:122937476 | RefSeq | XP_001138639.2 | 399 | PREDICTED: lipase member K [Pan troglodytes] |
| GI:122937476 | RefSeq | XP_002820996.2 | 399 | PREDICTED: lipase member K [Pongo abelii] |
| GI:122937476 | RefSeq | XP_003810556.1 | 399 | PREDICTED: lipase member K [Pan paniscus] |
| GI:122937476 | RefSeq | XP_003904012.1 | 399 | PREDICTED: lipase member K [Papio anubis] |
| GI:122937476 | RefSeq | XP_004049792.1 | 399 | PREDICTED: lipase member K [Gorilla gorilla gorilla] |
| GI:122937476 | RefSeq | XP_007961668.1 | 399 | PREDICTED: lipase member K [Chlorocebus sabaeus] |