Gene/Proteome Database (LMPD)

LMPD ID
LMP006708
Gene ID
114885
Species
Homo sapiens (Human)
Gene Name
oxysterol binding protein-like 11
Gene Symbol
OSBPL11
Synonyms
ORP-11; ORP11; OSBP12; TCCCIA00292
Alternate Names
oxysterol-binding protein-related protein 11; OSBP-related protein 11
Chromosome
3
Map Location
3q21
Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for OSBPL11

Proteins

oxysterol-binding protein-related protein 11
Refseq ID NP_073613
Protein GI 19923592
UniProt ID Q9BXB4
mRNA ID NM_022776
Length 747
RefSeq Status REVIEWED
MQGGEPVSTMKVSESEGKLEGQATAVTPNKNSSCGGGISSSSSSRGGSAKGWQYSDHMENVYGYLMKYTNLVTGWQYRFFVLNNEAGLLEYFVNEQSRNQKPRGTLQLAGAVISPSDEDSHTFTVNAASGEQYKLRATDAKERQHWVSRLQICTQHHTEAIGKNNPPLKSRSFSLASSSNSPISQRRPSQNAISFFNVGHSKLQSLSKRTNLPPDHLVEVREMMSHAEGQQRDLIRRIECLPTSGHLSSLDQDLLMLKATSMATMNCLNDCFHILQLQHASHQKGSLPSGTTIEWLEPKISLSNHYKNGADQPFATDQSKPVAVPEEQPVAESGLLAREPEEINADDEIEDTCDHKEDDLGAVEEQRSVILHLLSQLKLGMDLTRVVLPTFILEKRSLLEMYADFMSHPDLFIAITNGATAEDRMIRFVEYYLTSFHEGRKGAIAKKPYNPIIGETFHCSWKMPKSEVASSVFSSSSTQGVTNHAPLSGESLTQVGSDCYTVRFVAEQVSHHPPVSGFYAECTERKMCVNAHVWTKSKFLGMSIGVTMVGEGILSLLEHGEEYTFSLPCAYARSILTVPWVELGGKVSVNCAKTGYSASITFHTKPFYGGKLHRVTAEVKHNITNTVVCRVQGEWNSVLEFTYSNGETKYVDLTKLAVTKKRVRPLEKQDPFESRRLWKNVTDSLRESEIDKATEHKHTLEERQRTEERHRTETGTPWKTKYFIKEGDGWVYHKPLWKIIPTTQPAE

Gene Information

Entrez Gene ID
114885
Gene Name
oxysterol binding protein-like 11
Gene Symbol
OSBPL11
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005768 IEA:UniProtKB-KW C endosome
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0045444 IMP:BHF-UCL P fat cell differentiation
GO:0006869 IEA:UniProtKB-KW P lipid transport
GO:0010890 IMP:BHF-UCL P positive regulation of sequestering of triglyceride

Domain Information

InterPro Annotations

Accession Description
IPR000648 Oxysterol-binding protein
IPR018494 Oxysterol-binding protein, conserved site
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
oxysterol binding protein-like 11
Protein Entry
OSB11_HUMAN
UniProt ID
Q9BXB4
Species
Human

Comments

Comment Type Description
Domain The PH domain binds phosphoinositides.
Similarity Belongs to the OSBP family.
Similarity Contains 1 PH domain. {ECO
Subcellular Location Late endosome membrane . Golgi apparatus, trans-Golgi network membrane . Note=Localizes at the Golgi-late endosome interface.
Subunit Heterodimer with OSBPL9.
Tissue Specificity Present at highest levels in ovary, testis, kidney, liver, stomach, brain, and adipose tissue. Strong expression (at protein level) in epithelial cells of kidney tubules, testicular tubules, caecum, and skin.

Identical and Related Proteins

Unique RefSeq proteins for LMP006708 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
19923592 RefSeq NP_073613 747 oxysterol-binding protein-related protein 11

Identical Sequences to LMP006708 proteins

Reference Database Accession Length Protein Name
GI:19923592 DBBJ BAF85391.1 747 unnamed protein product [Homo sapiens]
GI:19923592 DBBJ BAG10618.1 747 oxysterol-binding protein-related protein 11, partial [synthetic construct]
GI:19923592 GenBank EAW79389.1 747 oxysterol binding protein-like 11 [Homo sapiens]
GI:19923592 GenBank ACE86643.1 747 oxysterol binding protein-like 11 protein, partial [synthetic construct]
GI:19923592 GenBank ACE87325.1 747 oxysterol binding protein-like 11 protein [synthetic construct]
GI:19923592 GenBank AHD77284.1 747 Sequence 22417 from patent US 8586006

Related Sequences to LMP006708 proteins

Reference Database Accession Length Protein Name
GI:19923592 GenBank JAA09285.1 747 oxysterol binding protein-like 11 [Pan troglodytes]
GI:19923592 GenBank JAA14360.1 747 oxysterol binding protein-like 11 [Pan troglodytes]
GI:19923592 GenBank JAA26410.1 747 oxysterol binding protein-like 11 [Pan troglodytes]
GI:19923592 RefSeq XP_001169528.1 747 PREDICTED: oxysterol-binding protein-related protein 11 [Pan troglodytes]
GI:19923592 RefSeq XP_009444617.1 747 PREDICTED: oxysterol-binding protein-related protein 11 [Pan troglodytes]
GI:19923592 RefSeq XP_009444618.1 747 PREDICTED: oxysterol-binding protein-related protein 11 [Pan troglodytes]