Gene/Proteome Database (LMPD)

LMPD ID
LMP006714
Gene ID
80055
Species
Homo sapiens (Human)
Gene Name
post-GPI attachment to proteins 1
Gene Symbol
PGAP1
Synonyms
Bst1; ISPD3024; MRT42; SPG67
Alternate Names
GPI inositol-deacylase; hPGAP1; GPI deacylase; post-GPI attachment to proteins factor 1
Chromosome
2
Map Location
2q33.1
EC Number
3.1.-.-
Summary
PGAP1 catalyzes the inositol deacylation of glycosylphosphatidylinositol (GPI) at an early step in GPI biosynthesis. Inositol deacylation is essential for the generation of mature GPI capable of attachment to proteins (Tanaka et al., 2004 [PubMed 14734546]).[supplied by OMIM, Mar 2008]
Orthologs
View orthologs and multiple alignments for PGAP1

Proteins

GPI inositol-deacylase
Refseq ID NP_079265
Protein GI 46240862
UniProt ID Q75T13
mRNA ID NM_024989
Length 922
RefSeq Status VALIDATED
MFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYLYGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLYKGQEFAPKSVAIIGHSMGGLVARALLTLKNFKHDLINLLITQATPHVAPVMPLDRFITDFYTTVNNYWILNARHINLTTLSVAGGFRDYQVRSGLTFLPKLSHHTSALSVVSSAVPKTWVSTDHLSIVWCKQLQLTTVRAFFDLIDADTKQITQNSKKKLSVLYHHFIRHPSKHFEENPAIISDLTGTSMWVLVKVSKWTYVAYNESEKIYFTFPLENHRKIYTHVYCQSTMLDTNSWIFACINSTSMCLQGVDLSWKAELLPTIKYLTLRLQDYPSLSHLVVYVPSVRGSKFVVDCEFFKKEKRYIQLPVTHLFSFGLSSRKVVLNTNGLYYNLELLNFGQIYQAFKINVVSKCSAVKEEITSIYRLHIPWSYEDSLTIAQAPSSTEISLKLHIAQPENNTHVALFKMYTSSDCRYEVTVKTSFSQILGQVVRFHGGALPAYVVSNILLAYRGQLYSLFSTGCCLEYATMLDKEAKPYKVDPFVIIIKFLLGYKWFKELWDVLLLPELDAVILTCQSMCFPLISLILFLFGTCTAYWSGLLSSASVRLLSSLWLALKRPSELPKDIKMISPDLPFLTIVLIIVSWTTCGALAILLSYLYYVFKVVHLQASLTTFKNSQPVNPKHSRRSEKKSNHHKDSSIHHLRLSANDAEDSLRMHSTVINLLTWIVLLSMPSLIYWLKNLRYYFKLNPDPCKPLAFILIPTMAILGNTYTVSIKSSKLLKTTSQFPLPLAVGVIAFGSAHLYRLPCFVFIPLLLHALCNFM

Gene Information

Entrez Gene ID
80055
Gene Name
post-GPI attachment to proteins 1
Gene Symbol
PGAP1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 ISS:UniProtKB C endoplasmic reticulum
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0004518 ISS:UniProtKB F nuclease activity
GO:0042578 ISS:UniProtKB F phosphoric ester hydrolase activity
GO:0006501 TAS:Reactome P C-terminal protein lipidation
GO:0009948 IEA:Ensembl P anterior/posterior axis specification
GO:0016255 TAS:Reactome P attachment of GPI anchor to protein
GO:0044267 TAS:Reactome P cellular protein metabolic process
GO:0009880 IEA:Ensembl P embryonic pattern specification
GO:0021871 IEA:Ensembl P forebrain regionalization
GO:0060322 IEA:Ensembl P head development
GO:0006886 IEA:InterPro P intracellular protein transport
GO:0015798 ISS:UniProtKB P myo-inositol transport
GO:0043687 TAS:Reactome P post-translational protein modification
GO:0007605 IEA:Ensembl P sensory perception of sound

KEGG Pathway Links

KEGG Pathway ID Description
hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
ko00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
hsa01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_1830 Attachment of GPI anchor to uPAR

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR012908 GPI inositol-deacylase PGAP1-like

UniProt Annotations

Entry Information

Gene Name
post-GPI attachment to proteins 1
Protein Entry
PGAP1_HUMAN
UniProt ID
Q75T13
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q75T13-1; Sequence=Displayed; Name=2; IsoId=Q75T13-2; Sequence=VSP_023040; Note=No experimental confirmation available.; Name=3; IsoId=Q75T13-3; Sequence=VSP_023042, VSP_023043; Note=No experimental confirmation available.; Name=4; IsoId=Q75T13-4; Sequence=VSP_023041, VSP_023044; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.;
Disease Mental retardation, autosomal recessive 42 (MRT42) [MIM
Function Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi (By similarity).
Sequence Caution Sequence=AAQ88987.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Evidence= ; Sequence=BC040517; Type=Frameshift; Positions=333; Evidence= ;
Similarity Belongs to the GPI inositol-deacylase family.
Subcellular Location Endoplasmic reticulum membrane {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP006714 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
46240862 RefSeq NP_079265 922 GPI inositol-deacylase

Identical Sequences to LMP006714 proteins

Reference Database Accession Length Protein Name
GI:46240862 DBBJ BAD13427.1 922 GPI inositol-deacylase PGAP1 [Homo sapiens]
GI:46240862 DBBJ BAI45517.1 922 post-GPI attachment to proteins 1, partial [synthetic construct]
GI:46240862 GenBank AAI52720.1 922 Post-GPI attachment to proteins 1, partial [synthetic construct]
GI:46240862 GenBank AHD73268.1 922 Sequence 10336 from patent US 8586006
GI:46240862 SwissProt Q75T13.1 922 RecName: Full=GPI inositol-deacylase; AltName: Full=Post-GPI attachment to proteins factor 1; Short=hPGAP1 [Homo sapiens]

Related Sequences to LMP006714 proteins

Reference Database Accession Length Protein Name
GI:46240862 GenBank JAA09277.1 922 post-GPI attachment to proteins 1 [Pan troglodytes]
GI:46240862 GenBank JAA19754.1 922 post-GPI attachment to proteins 1 [Pan troglodytes]
GI:46240862 GenBank JAA23502.1 922 post-GPI attachment to proteins 1 [Pan troglodytes]
GI:46240862 GenBank JAA42898.1 922 post-GPI attachment to proteins 1 [Pan troglodytes]
GI:46240862 GenBank JAA42899.1 922 post-GPI attachment to proteins 1 [Pan troglodytes]
GI:46240862 RefSeq XP_004033040.1 922 PREDICTED: GPI inositol-deacylase [Gorilla gorilla gorilla]