Gene/Proteome Database (LMPD)
Proteins
| phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform a | |
|---|---|
| Refseq ID | NP_001271214 |
| Protein GI | 546230990 |
| UniProt ID | Q15735 |
| mRNA ID | NM_001284285 |
| Length | 1006 |
| RefSeq Status | VALIDATED |
| MEGQSSRGSRRPGTRAGLGSLPMPQGVAQTGAPSKVDSSFQLPAKKNAALGPSEPRLALAPVGPRAAMSASSEGPRLALASPRPILAPLCTPEGQKTATAHRSSSLAPTSVGQLVMSASAGPKPPPATTGSVLAPTSLGLVMPASAGPRSPPVTLGPNLAPTSRDQKQEPPASVGPKPTLAASGLSLALASEEQPPELPSTPSPVPSPVLSPTQEQALAPASTASGAASVGQTSARKRDAPAPRPLPASEGHLQPPAQTSGPTGSPPCIQTSPDPRLSPSFRARPEALHSSPEDPVLPRPPQTLPLDVGQGPSEPGTHSPGLLSPTFRPGAPSGQTVPPPLPKPPRSPSRSPSHSPNRSPCVPPAPDMALPRLGTQSTGPGRCLSPNLQAQEAPAPVTTSSSTSTLSSSPWSAQPTWKSDPGFRITVVTWNVGTAMPPDDVTSLLHLGGGDDSDGADMIAIGLQEVNSMLNKRLKDALFTDQWSELFMDALGPFNFVLVSSVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAQGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSDQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWKVKAPGGGPSPSGRKSHRLQVTQHSYRSHMEYTVSDHKPVAAQFLLQFAFRDDMPLVRLEVADEWVRPEQAVVRYRMETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKHEDVDGNTYQVTFSEESLPKGHGDFILGYYSHNHSILIGITEPFQISLPSSELASSSTDSSGTSSEGEDDSTLELLAPKSRSPSPGKSKRHRSRSPGLARFPGLALRPSSRERRGASRSPSPQSRRLSRVAPDRSSNGSSRGSSEEGPSGLPGPWAFPPAVPRSLGLLPALRLETVDPGGGGSWGPDREALAPNSLSPSPQGHRGLEEGGLGP | |
| phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform b | |
|---|---|
| Refseq ID | NP_001271215 |
| Protein GI | 546231222 |
| UniProt ID | B4DF95 |
| mRNA ID | NM_001284286 |
| Length | 939 |
| RefSeq Status | VALIDATED |
| MSASSEGPRLALASPRPILAPLCTPEGQKTATAHRSSSLAPTSVGQLVMSASAGPKPPPATTGSVLAPTSLGLVMPASAGPRSPPVTLGPNLAPTSRDQKQEPPASVGPKPTLAASGLSLALASEEQPPELPSTPSPVPSPVLSPTQEQALAPASTASGAASVGQTSARKRDAPAPRPLPASEGHLQPPAQTSGPTGSPPCIQTSPDPRLSPSFRARPEALHSSPEDPVLPRPPQTLPLDVGQGPSEPGTHSPGLLSPTFRPGAPSGQTVPPPLPKPPRSPSRSPSHSPNRSPCVPPAPDMALPRLGTQSTGPGRCLSPNLQAQEAPAPVTTSSSTSTLSSSPWSAQPTWKSDPGFRITVVTWNVGTAMPPDDVTSLLHLGGGDDSDGADMIAIGLQEVNSMLNKRLKDALFTDQWSELFMDALGPFNFVLVSSVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAQGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSDQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWKVKAPGGGPSPSGRKSHRLQVTQHSYRSHMEYTVSDHKPVAAQFLLQFAFRDDMPLVRLEVADEWVRPEQAVVRYRMETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKHEDVDGNTYQVTFSEESLPKGHGDFILGYYSHNHSILIGITEPFQISLPSSELASSSTDSSGTSSEGEDDSTLELLAPKSRSPSPGKSKRHRSRSPGLARFPGLALRPSSRERRGASRSPSPQSRRLSRVAPDRSSNGSSRGSSEEGPSGLPGPWAFPPAVPRSLGLLPALRLETVDPGGGGSWGPDREALAPNSLSPSPQGHRGLEEGGLGP | |
| phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform c | |
|---|---|
| Refseq ID | NP_001002837 |
| Protein GI | 50726960 |
| UniProt ID | Q15735 |
| mRNA ID | NM_001002837 |
| Length | 638 |
| RefSeq Status | VALIDATED |
| MEGQSSRGSRRPGTRAGLGSLPMPQGVAQTGAPSKVDSSFQLPAKKNAALGPSEPRITVVTWNVGTAMPPDDVTSLLHLGGGDDSDGADMIAIGLQEVNSMLNKRLKDALFTDQWSELFMDALGPFNFVLVSSVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAQGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSDQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWKVKAPGGGPSPSGRKSHRLQVTQHSYRSHMEYTVSDHKPVAAQFLLQFAFRDDMPLVRLEVADEWVRPEQAVVRYRMETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKHEDVDGNTYQVTFSEESLPKGHGDFILGYYSHNHSILIGITEPFQISLPSSELASSSTDSSGTSSEGEDDSTLELLAPKSRSPSPGKSKRHRSRSPGLARFPGLALRPSSRERRGASRSPSPQSRRLSRVAPDRSSNGSSRGSSEEGPSGLPGPWAFPPAVPRSLGLLPALRLETVDPGGGGSWGPDREALAPNSLSPSPQGHRGLEEGGLGP | |
| phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform e | |
|---|---|
| Refseq ID | NP_001271217 |
| Protein GI | 546230866 |
| UniProt ID | Q15735 |
| mRNA ID | NM_001284288 |
| Length | 639 |
| RefSeq Status | VALIDATED |
| MALPRLGTQSTGPGRCLSPNLQAQEAPAPVTTSSSTSTLSSSPWSAQPTWKSDPGFRITVVTWNVGTAMPPDDVTSLLHLGGGDDSDGADMIAIGLQEVNSMLNKRLKDALFTDQWSELFMDALGPFNFVLVSSVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAQGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSDQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWKVKAPGGGPSPSGRKSHRLQVTQHSYRSHMEYTVSDHKPVAAQFLLQFAFRDDMPLVRLEVADEWVRPEQAVVRYRMETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKHEDVDGNTYQVTFSEESLPKGHGDFILGYYSHNHSILIGITEPFQISLPSSELASSSTDSSGTSSEGEDDSTLELLAPKSRSPSPGKSKRHRSRSPGLARFPGLALRPSSRERRGASRSPSPQSRRLSRVAPDRSSNGSSRGSSEEGPSGLPGPWAFPPAVPRSLGLLPALRLETVDPGGGGSWGPDREALAPNSLSPSPQGHRGLEEGGLGP | |
| phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform e | |
|---|---|
| Refseq ID | NP_001271218 |
| Protein GI | 546231863 |
| UniProt ID | Q15735 |
| mRNA ID | NM_001284289 |
| Length | 639 |
| RefSeq Status | VALIDATED |
| Protein sequence is identical to GI:546230866 (mRNA isoform) | |
Gene Information
Entrez Gene ID
Gene Name
inositol polyphosphate-5-phosphatase J
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IDA:MGI | C | cytoplasm |
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0043198 | IEA:Ensembl | C | dendritic shaft |
| GO:0030426 | IEA:Ensembl | C | growth cone |
| GO:0005886 | IEA:Ensembl | C | plasma membrane |
| GO:0001726 | IDA:MGI | C | ruffle |
| GO:0052659 | IEA:UniProtKB-EC | F | inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity |
| GO:0052658 | IEA:UniProtKB-EC | F | inositol-1,4,5-trisphosphate 5-phosphatase activity |
| GO:0004445 | IEA:UniProtKB-EC | F | inositol-polyphosphate 5-phosphatase activity |
| GO:0034485 | IEA:Ensembl | F | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity |
| GO:0043647 | TAS:Reactome | P | inositol phosphate metabolic process |
| GO:0031115 | IEA:Ensembl | P | negative regulation of microtubule polymerization |
| GO:0010977 | IEA:Ensembl | P | negative regulation of neuron projection development |
| GO:0033137 | IEA:Ensembl | P | negative regulation of peptidyl-serine phosphorylation |
| GO:0006661 | TAS:Reactome | P | phosphatidylinositol biosynthetic process |
| GO:0046856 | IEA:InterPro | P | phosphatidylinositol dephosphorylation |
| GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6362 | 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_150352 | Synthesis of IP2, IP, and Ins in the cytosol |
| REACT_150312 | Synthesis of IP3 and IP4 in the cytosol |
| REACT_121025 | Synthesis of PIPs at the plasma membrane |
Domain Information
UniProt Annotations
Entry Information
Gene Name
inositol polyphosphate-5-phosphatase J
Protein Entry
B4DF95_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q15735-1; Sequence=Displayed; Name=2; IsoId=Q15735-2; Sequence=VSP_007296; Name=3; IsoId=Q15735-3; Sequence=VSP_021017; Note=No experimental confirmation available.; |
| Catalytic Activity | 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. |
| Catalytic Activity | D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate. |
| Domain | The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein. |
| Function | Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate- binding proteins that are present at membranes ruffles (By similarity). |
| Sequence Caution | Sequence=AAD15618.1; Type=Erroneous gene model prediction; Evidence= ; |
| Similarity | Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type II family. |
| Subcellular Location | Cytoplasm . Note=Predominantly localized to membrane ruffles. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006715 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 546230990 | RefSeq | NP_001271214 | 1006 | phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform a |
| 546231222 | RefSeq | NP_001271215 | 939 | phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform b |
| 50726960 | RefSeq | NP_001002837 | 638 | phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform c |
| 546230866 | RefSeq | NP_001271217 | 639 | phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform e |
Identical Sequences to LMP006715 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:546230866 | DBBJ | BAG52616.1 | 639 | unnamed protein product [Homo sapiens] |
| GI:546231222 | DBBJ | BAG57356.1 | 939 | unnamed protein product [Homo sapiens] |
| GI:546230990 | GenBank | ABA09103.1 | 1006 | Sequence 12 from patent US 6908743 |
| GI:546230866 | GenBank | ABA67626.1 | 639 | Sequence 3268 from patent US 6943241 |
| GI:546230990 | GenBank | ABH71151.1 | 1006 | Sequence 84 from patent US 7033790 |
| GI:546230866 | GenBank | EAW59936.1 | 639 | phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A, isoform CRA_a [Homo sapiens] |
| GI:546230990 | GenBank | EAW59937.1 | 1006 | phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A, isoform CRA_b [Homo sapiens] |
| GI:50726960 | GenBank | EAW59939.1 | 638 | phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A, isoform CRA_d [Homo sapiens] |
| GI:546230866 | GenBank | ABP28410.1 | 639 | Sequence 3425 from patent US 7193069 |
| GI:50726960 | GenBank | AHD73274.1 | 638 | Sequence 10342 from patent US 8586006 |
| GI:546230866 | GenBank | AHD73275.1 | 639 | Sequence 10343 from patent US 8586006 |
| GI:546230866 | RefSeq | NP_001271218.1 | 639 | phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform e [Homo sapiens] |
| GI:546230990 | SwissProt | Q15735.3 | 1006 | RecName: Full=Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; AltName: Full=Inositol polyphosphate 5-phosphatase J [Homo sapiens] |
Related Sequences to LMP006715 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:50726960 | DBBJ | BAC86611.1 | 638 | unnamed protein product [Homo sapiens] |
| GI:546230990 | GenBank | AAD15618.1 | 1056 | similar to phosphatidylinositol (4,5)bisphosphate 5-phosphatase; match to PID:g1399105, partial [Homo sapiens] |
| GI:546231222 | GenBank | AAD15618.1 | 1056 | similar to phosphatidylinositol (4,5)bisphosphate 5-phosphatase; match to PID:g1399105, partial [Homo sapiens] |
| GI:546231222 | GenBank | ABA09103.1 | 1006 | Sequence 12 from patent US 6908743 |
| GI:546230866 | GenBank | ABA09103.1 | 1006 | Sequence 12 from patent US 6908743 |
| GI:546230866 | GenBank | ABH71151.1 | 1006 | Sequence 84 from patent US 7033790 |
| GI:546231222 | GenBank | ABH71151.1 | 1006 | Sequence 84 from patent US 7033790 |
| GI:546231222 | GenBank | EAW59937.1 | 1006 | phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A, isoform CRA_b [Homo sapiens] |
| GI:546230866 | GenBank | EAW59937.1 | 1006 | phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A, isoform CRA_b [Homo sapiens] |
| GI:546230990 | GenBank | EAW59938.1 | 1044 | phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A, isoform CRA_c [Homo sapiens] |
| GI:50726960 | RefSeq | XP_002798372.1 | 638 | PREDICTED: phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform 2 [Macaca mulatta] |
| GI:50726960 | RefSeq | XP_003258144.1 | 638 | PREDICTED: phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform 1 [Nomascus leucogenys] |
| GI:546230990 | RefSeq | XP_003826978.1 | 1007 | PREDICTED: phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform X2 [Pan paniscus] |
| GI:546230990 | RefSeq | XP_004063367.1 | 1007 | PREDICTED: phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform 1 [Gorilla gorilla gorilla] |
| GI:546230990 | RefSeq | XP_004063368.1 | 1008 | PREDICTED: phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform 2 [Gorilla gorilla gorilla] |
| GI:50726960 | RefSeq | XP_004063369.1 | 638 | PREDICTED: phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform 3 [Gorilla gorilla gorilla] |
| GI:546230866 | RefSeq | NP_001271214.1 | 1006 | phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform a [Homo sapiens] |
| GI:546231222 | RefSeq | NP_001271214.1 | 1006 | phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform a [Homo sapiens] |
| GI:546230866 | RefSeq | NP_001271215.1 | 939 | phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform b [Homo sapiens] |
| GI:50726960 | RefSeq | XP_009007650.1 | 666 | PREDICTED: phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform X2 [Callithrix jacchus] |
| GI:546230990 | RefSeq | XP_009436457.1 | 1007 | PREDICTED: phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform X1 [Pan troglodytes] |
| GI:50726960 | RefSeq | XP_009436462.1 | 638 | PREDICTED: phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform X5 [Pan troglodytes] |
| GI:546231222 | SwissProt | Q15735.3 | 1006 | RecName: Full=Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; AltName: Full=Inositol polyphosphate 5-phosphatase J [Homo sapiens] |
| GI:546230866 | SwissProt | Q15735.3 | 1006 | RecName: Full=Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; AltName: Full=Inositol polyphosphate 5-phosphatase J [Homo sapiens] |