Gene/Proteome Database (LMPD)

LMPD ID
LMP006719
Gene ID
254240
Species
Homo sapiens (Human)
Gene Name
BPI fold containing family C
Gene Symbol
BPIFC
Synonyms
BPIL2
Alternate Names
BPI fold-containing family C protein; BPI-like 2; bactericidal/permeability-increasing protein-like 2
Chromosome
22
Map Location
22q12.3

Proteins

BPI fold-containing family C protein precursor
Refseq ID NP_777592
Protein GI 28372551
UniProt ID Q8NFQ6
mRNA ID NM_174932
Length 507
RefSeq Status VALIDATED
MCTKTIPVLWGCFLLWNLYVSSSQTIYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKISAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFQDTGGADLFLSGVYFTGIIILTRNDFGHPTLKLQDCYAQLSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIASEVKALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPPFSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEISNHFVQNSQGLGNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLANAKLQQGFPLSNPHKFLFVNSDIEVLEGFLLISTDLKYETSSKQQPSFHVWEGLNLISRQWRGKSAP
sig_peptide: 1..23 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2662 peptide sequence: MCTKTIPVLWGCFLLWNLYVSSS mat_peptide: 24..507 product: BPI fold-containing family C protein experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8NFQ6.1) calculated_mol_wt: 53825 peptide sequence: QTIYPGIKARITQRALDYGVQAGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKISAFSFPNTSLAFVPGVGIKALTNHGTANISTDWGFESPLFQDTGGADLFLSGVYFTGIIILTRNDFGHPTLKLQDCYAQLSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIASEVKALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPPFSPVPFVLPERSNSMLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEISNHFVQNSQGLGNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLANAKLQQGFPLSNPHKFLFVNSDIEVLEGFLLISTDLKYETSSKQQPSFHVWEGLNLISRQWRGKSAP

Gene Information

Entrez Gene ID
254240
Gene Name
BPI fold containing family C
Gene Symbol
BPIFC
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IEA:UniProtKB-KW C extracellular region
GO:0001530 NAS:UniProtKB F lipopolysaccharide binding
GO:0005543 NAS:UniProtKB F phospholipid binding

Domain Information

InterPro Annotations

Accession Description
IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain
IPR001124 Lipid-binding serum glycoprotein, C-terminal
IPR017942 Lipid-binding serum glycoprotein, N-terminal
IPR017954 Lipid-binding serum glycoprotein, conserved site

UniProt Annotations

Entry Information

Gene Name
BPI fold containing family C
Protein Entry
BPIFC_HUMAN
UniProt ID
Q8NFQ6
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NFQ6-1; Sequence=Displayed; Name=2; IsoId=Q8NFQ6-2; Sequence=VSP_056033, VSP_056034; Note=No experimental confirmation available.;
Similarity Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Subcellular Location Secreted .
Tissue Specificity Detected in the basal layer of the epidermis from inflammatory skin from psoriasis patients, but not in normal skin.

Identical and Related Proteins

Unique RefSeq proteins for LMP006719 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
28372551 RefSeq NP_777592 507 BPI fold-containing family C protein precursor

Identical Sequences to LMP006719 proteins

Reference Database Accession Length Protein Name
GI:28372551 GenBank AAM73984.1 507 bactericidal/permeability-increasing protein-like 2 [Homo sapiens]
GI:28372551 GenBank EAW60022.1 507 bactericidal/permeability-increasing protein-like 2 [Homo sapiens]
GI:28372551 GenBank AHE01973.1 507 Sequence 59822 from patent US 8586006
GI:28372551 SwissProt Q8NFQ6.1 507 RecName: Full=BPI fold-containing family C protein; AltName: Full=Bactericidal/permeability-increasing protein-like 2; Short=BPI-like 2; Flags: Precursor [Homo sapiens]

Related Sequences to LMP006719 proteins

Reference Database Accession Length Protein Name
GI:28372551 GenBank EHH20174.1 507 hypothetical protein EGK_02973 [Macaca mulatta]
GI:28372551 RefSeq XP_003258177.1 507 PREDICTED: BPI fold-containing family C protein [Nomascus leucogenys]
GI:28372551 RefSeq XP_001140044.2 507 PREDICTED: BPI fold-containing family C protein isoform X1 [Pan troglodytes]
GI:28372551 RefSeq XP_005567548.1 507 PREDICTED: BPI fold-containing family C protein isoform X1 [Macaca fascicularis]
GI:28372551 RefSeq XP_009436520.1 507 PREDICTED: BPI fold-containing family C protein isoform X1 [Pan troglodytes]
GI:28372551 RefSeq XP_009436521.1 507 PREDICTED: BPI fold-containing family C protein isoform X1 [Pan troglodytes]