Gene/Proteome Database (LMPD)

LMPD ID
LMP006723
Gene ID
54988
Species
Homo sapiens (Human)
Gene Name
acyl-CoA synthetase medium-chain family member 5
Gene Symbol
ACSM5
Synonyms
-
Alternate Names
acyl-coenzyme A synthetase ACSM5, mitochondrial
Chromosome
16
Map Location
16p12.3
EC Number
6.2.1.2

Proteins

acyl-coenzyme A synthetase ACSM5, mitochondrial precursor
Refseq ID NP_060358
Protein GI 38505220
UniProt ID Q6NUN0
mRNA ID NM_017888
Length 579
RefSeq Status VALIDATED
MRPWLRHLVLQALRNSRAFCGSHGKPAPLPVPQKIVATWEAISLGRQLVPEYFNFAHDVLDVWSRLEEAGHRPPNPAFWWVNGTGAEIKWSFEELGKQSRKAANVLGGACGLQPGDRMMLVLPRLPEWWLVSVACMRTGTVMIPGVTQLTEKDLKYRLQASRAKSIITSDSLAPRVDAISAECPSLQTKLLVSDSSRPGWLNFRELLREASTEHNCMRTKSRDPLAIYFTSGTTGAPKMVEHSQSSYGLGFVASGRRWVALTESDIFWNTTDTGWVKAAWTLFSAWPNGSCIFVHELPRVDAKVILNTLSKFPITTLCCVPTIFRLLVQEDLTRYQFQSLRHCLTGGEALNPDVREKWKHQTGVELYEGYGQSETVVICANPKGMKIKSGSMGKASPPYDVQIVDDEGNVLPPGEEGNVAVRIRPTRPFCFFNCYLDNPEKTAASEQGDFYITGDRARMDKDGYFWFMGRNDDVINSSSYRIGPVEVESALAEHPAVLESAVVSSPDPIRGEVVKAFIVLTPAYSSHDPEALTRELQEHVKRVTAPYKYPRKVAFVSELPKTVSGKIQRSKLRSQEWGK
transit_peptide: 1..26 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q6NUN0.2) calculated_mol_wt: 3032 peptide sequence: MRPWLRHLVLQALRNSRAFCGSHGKP mat_peptide: 27..579 product: Acyl-coenzyme A synthetase ACSM5, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q6NUN0.2) calculated_mol_wt: 61747 peptide sequence: APLPVPQKIVATWEAISLGRQLVPEYFNFAHDVLDVWSRLEEAGHRPPNPAFWWVNGTGAEIKWSFEELGKQSRKAANVLGGACGLQPGDRMMLVLPRLPEWWLVSVACMRTGTVMIPGVTQLTEKDLKYRLQASRAKSIITSDSLAPRVDAISAECPSLQTKLLVSDSSRPGWLNFRELLREASTEHNCMRTKSRDPLAIYFTSGTTGAPKMVEHSQSSYGLGFVASGRRWVALTESDIFWNTTDTGWVKAAWTLFSAWPNGSCIFVHELPRVDAKVILNTLSKFPITTLCCVPTIFRLLVQEDLTRYQFQSLRHCLTGGEALNPDVREKWKHQTGVELYEGYGQSETVVICANPKGMKIKSGSMGKASPPYDVQIVDDEGNVLPPGEEGNVAVRIRPTRPFCFFNCYLDNPEKTAASEQGDFYITGDRARMDKDGYFWFMGRNDDVINSSSYRIGPVEVESALAEHPAVLESAVVSSPDPIRGEVVKAFIVLTPAYSSHDPEALTRELQEHVKRVTAPYKYPRKVAFVSELPKTVSGKIQRSKLRSQEWGK

Gene Information

Entrez Gene ID
54988
Gene Name
acyl-CoA synthetase medium-chain family member 5
Gene Symbol
ACSM5
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0005525 IEA:UniProtKB-KW F GTP binding
GO:0047760 IEA:UniProtKB-EC F butyrate-CoA ligase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa01100 Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6000 gamma-linolenate biosynthesis II (animals)

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_6812 Conjugation of salicylate with glycine
REACT_6959 Phase II conjugation

Domain Information

InterPro Annotations

Accession Description
IPR025110 AMP-binding enzyme C-terminal domain
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase medium-chain family member 5
Protein Entry
ACSM5_HUMAN
UniProt ID
Q6NUN0
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NUN0-1; Sequence=Displayed; Name=2; IsoId=Q6NUN0-2; Sequence=VSP_028398; Note=No experimental confirmation available.;
Catalytic Activity ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor Name=Mg(2+); Xref=ChEBI
Function Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity).
Sequence Caution Sequence=BAA91273.1; Type=Frameshift; Positions=560; Evidence= ;
Similarity Belongs to the ATP-dependent AMP-binding enzyme family.
Subcellular Location Mitochondrion matrix .
Tissue Specificity Detected in kidney and liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP006723 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
38505220 RefSeq NP_060358 579 acyl-coenzyme A synthetase ACSM5, mitochondrial precursor

Identical Sequences to LMP006723 proteins

Reference Database Accession Length Protein Name
GI:38505220 GenBank AHE01205.1 579 Sequence 56121 from patent US 8586006
GI:38505220 SwissProt Q6NUN0.2 579 RecName: Full=Acyl-coenzyme A synthetase ACSM5, mitochondrial; AltName: Full=Acyl-CoA synthetase medium-chain family member 5; Flags: Precursor [Homo sapiens]

Related Sequences to LMP006723 proteins

Reference Database Accession Length Protein Name
GI:38505220 GenBank AAH68516.1 579 Acyl-CoA synthetase medium-chain family member 5 [Homo sapiens]
GI:38505220 GenBank AIC56599.1 579 ACSM5, partial [synthetic construct]
GI:38505220 RefSeq XP_001156353.1 579 PREDICTED: acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X2 [Pan troglodytes]
GI:38505220 RefSeq XP_002826249.1 579 PREDICTED: acyl-coenzyme A synthetase ACSM5, mitochondrial [Pongo abelii]
GI:38505220 RefSeq XP_003930202.1 579 PREDICTED: acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X2 [Saimiri boliviensis boliviensis]
GI:38505220 RefSeq XP_005591454.1 580 PREDICTED: acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X3 [Macaca fascicularis]