Gene/Proteome Database (LMPD)
LMPD ID
LMP006724
Gene ID
Species
Homo sapiens (Human)
Gene Name
phospholipase C-like 1
Gene Symbol
Synonyms
PLCE; PLCL; PLDL1; PPP1R127; PRIP
Alternate Names
inactive phospholipase C-like protein 1; PLC-L1; phospholipase C, epsilon; phospholipase C-deleted in lung carcinoma; protein phosphatase 1, regulatory subunit 127; phospholipase C-related but catalytically inactive protein; phospholipase C related, but catalytically inactive protein
Chromosome
2
Map Location
2q33
Proteins
| inactive phospholipase C-like protein 1 | |
|---|---|
| Refseq ID | NP_006217 |
| Protein GI | 254939661 |
| UniProt ID | Q15111 |
| mRNA ID | NM_006226 |
| Length | 1095 |
| RefSeq Status | VALIDATED |
| MAEGAAGREDPAPPDAAGGEDDPRVGPDAAGDCVTAASGGRMRDRRSGVALPGAAGTPADSEAGLLEAARATPRRSSIIKDPSNQKCGGRKKTVSFSSMPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSSRLITSDNTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIENMKQIQLACLSCGLSKAPSSSAEAKSKRSLEAIEEKESSEENGKL | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IEA:UniProtKB-KW | C | cytoplasm |
| GO:0005886 | IEA:Ensembl | C | plasma membrane |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0070679 | IEA:InterPro | F | inositol 1,4,5 trisphosphate binding |
| GO:0004435 | IEA:InterPro | F | phosphatidylinositol phospholipase C activity |
| GO:0004629 | TAS:ProtInc | F | phospholipase C activity |
| GO:0004871 | IEA:UniProtKB-KW | F | signal transducer activity |
| GO:0007214 | IEA:Ensembl | P | gamma-aminobutyric acid signaling pathway |
| GO:0035556 | TAS:ProtInc | P | intracellular signal transduction |
| GO:0006629 | IEA:InterPro | P | lipid metabolic process |
| GO:1900122 | IEA:Ensembl | P | positive regulation of receptor binding |
| GO:0033135 | IEA:Ensembl | P | regulation of peptidyl-serine phosphorylation |
| GO:0032228 | IEA:Ensembl | P | regulation of synaptic transmission, GABAergic |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR000008 | C2 domain |
| IPR011992 | EF-hand domain pair |
| IPR028382 | Inactive phospholipase C-like protein 1 |
| IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
| IPR001192 | Phosphoinositide phospholipase C family |
| IPR000909 | Phospholipase C, phosphatidylinositol-specific , X domain |
| IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
| IPR015359 | Phospholipase C, phosphoinositol-specific, EF-hand-like |
| IPR001849 | Pleckstrin homology domain |
| IPR011993 | Pleckstrin homology-like domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q15111-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q15111-2; Sequence=VSP_031475; |
| Caution | In the PI-PLC X-box Asn-458 is present instead of the conserved His which is one of the active site residues. It is therefore expected that this protein lacks catalytic activity. |
| Function | Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C. |
| Ptm | Phosphorylated by the catalytic subunit of PKA. Phosphorylation of Thr-93 resulted in dissociation of PPP1C from PRIP1 (By similarity). |
| Similarity | Contains 1 C2 domain. {ECO |
| Similarity | Contains 1 PH domain. {ECO |
| Similarity | Contains 1 PI-PLC X-box domain. {ECO |
| Similarity | Contains 1 PI-PLC Y-box domain. {ECO |
| Subcellular Location | Cytoplasm . |
| Subunit | Interacts with PPP2CA (By similarity). Interacts with Ins(1,4,5)P3, Ins(1,4,5,6)P4, GABARAP, GABA receptor beta subunits, GABA receptor gamma-2 subunits and PPP1C. May form a ternary complex with GABA receptor beta subunit and GABARAP. The formation of a ternary complex with GABA receptor beta subunit and GABARAP could be the key step for facilitating the association of GABARAP with the GABA receptor gamma-2 subunit and to allow it to be transported at the right destination. {ECO |
| Tissue Specificity | Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006724 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 254939661 | RefSeq | NP_006217 | 1095 | inactive phospholipase C-like protein 1 |
Identical Sequences to LMP006724 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:254939661 | SwissProt | Q15111.3 | 1095 | RecName: Full=Inactive phospholipase C-like protein 1; Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein; Short=PRIP [Homo sapiens] |
Related Sequences to LMP006724 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:254939661 | GenBank | JAA20911.1 | 1095 | phospholipase C-like 1 [Pan troglodytes] |
| GI:254939661 | GenBank | JAB50918.1 | 1095 | inactive phospholipase C-like protein 1 [Callithrix jacchus] |
| GI:254939661 | RefSeq | XP_001169560.1 | 1095 | PREDICTED: inactive phospholipase C-like protein 1 isoform X1 [Pan troglodytes] |
| GI:254939661 | RefSeq | XP_007963951.1 | 1095 | PREDICTED: inactive phospholipase C-like protein 1 isoform X1 [Chlorocebus sabaeus] |
| GI:254939661 | RefSeq | XP_002749649.3 | 1095 | PREDICTED: inactive phospholipase C-like protein 1 [Callithrix jacchus] |
| GI:254939661 | RefSeq | XP_003907820.2 | 1095 | PREDICTED: LOW QUALITY PROTEIN: inactive phospholipase C-like protein 1 [Papio anubis] |