Gene/Proteome Database (LMPD)
LMPD ID
LMP006725
Gene ID
Species
Homo sapiens (Human)
Gene Name
lysophosphatidylcholine acyltransferase 2
Gene Symbol
Synonyms
AYTL1; LysoPAFAT
Alternate Names
lysophosphatidylcholine acyltransferase 2; LPCAT-2; 1-AGPAT 11; LPAAT-alpha; LPC acyltransferase 2; acyltransferase like 1; acyltransferase-like 1; 1-AGP acyltransferase 11; lysoPC acyltransferase 2; lyso-PAF acetyltransferase; acetyl-CoA:lyso-PAF acetyltransferase; lysophosphatidic acid acyltransferase alpha; 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerol-3-phosphate O-acyltransferase 11; 1-alkylglycerophosphocholine O-acetyltransferase; acyl-CoA:lysophosphatidylcholine acyltransferase 2; lyso-platelet-activating factor (PAF) acetyltransferase; acetyl-CoA:lyso-platelet-activating factor acetyltransferase
Chromosome
16
Map Location
16q12.2
EC Number
2.3.1.23
Summary
This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009]
Orthologs
Proteins
| lysophosphatidylcholine acyltransferase 2 | |
|---|---|
| Refseq ID | NP_060309 |
| Protein GI | 47086907 |
| UniProt ID | Q7L5N7 |
| mRNA ID | NM_017839 |
| Length | 544 |
| RefSeq Status | REVIEWED |
| MSRCAQAAEVAATVPGAGVGNVGLRPPMVPRQASFFPPPVPNPFVQQTQIGSARRVQIVLLGIILLPIRVLLVALILLLAWPFAAISTVCCPEKLTHPITGWRRKITQTALKFLGRAMFFSMGFIVAVKGKIASPLEAPVFVAAPHSTFFDGIACVVAGLPSMVSRNENAQVPLIGRLLRAVQPVLVSRVDPDSRKNTINEIIKRTTSGGEWPQILVFPEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYPNKLDTVTWTWQGYTFIQLCMLTFCQLFTKVEVEFMPVQVPNDEEKNDPVLFANKVRNLMAEALGIPVTDHTYEDCRLMISAGQLTLPMEAGLVEFTKISRKLKLDWDGVRKHLDEYASIASSSKGGRIGIEEFAKYLKLPVSDVLRQLFALFDRNHDGSIDFREYVIGLAVLCNPSNTEEIIQVAFKLFDVDEDGYITEEEFSTILQASLGVPDLDVSGLFKEIAQGDSISYEEFKSFALKHPEYAKIFTTYLDLQTCHVFSLPKEVQTTPSTASNKVSPEKHEESTSDKKDD | |
Gene Information
Entrez Gene ID
Gene Name
lysophosphatidylcholine acyltransferase 2
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005795 | ISS:UniProtKB | C | Golgi stack |
| GO:0005783 | IDA:UniProtKB | C | endoplasmic reticulum |
| GO:0005789 | TAS:Reactome | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005811 | IDA:UniProtKB | C | lipid particle |
| GO:0003841 | IEA:UniProtKB-EC | F | 1-acylglycerol-3-phosphate O-acyltransferase activity |
| GO:0047184 | IDA:UniProtKB | F | 1-acylglycerophosphocholine O-acyltransferase activity |
| GO:0047192 | ISS:UniProtKB | F | 1-alkylglycerophosphocholine O-acetyltransferase activity |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0046474 | TAS:Reactome | P | glycerophospholipid biosynthetic process |
| GO:0061024 | ISS:UniProtKB | P | membrane organization |
| GO:0036151 | IDA:UniProtKB | P | phosphatidylcholine acyl-chain remodeling |
| GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
| GO:0006663 | ISS:UniProtKB | P | platelet activating factor biosynthetic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_120829 | Acyl chain remodelling of PC |
| REACT_121401 | Glycerophospholipid biosynthesis |
Domain Information
UniProt Annotations
Entry Information
Gene Name
lysophosphatidylcholine acyltransferase 2
Protein Entry
PCAT2_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7L5N7-1; Sequence=Displayed; Name=2; IsoId=Q7L5N7-2; Sequence=VSP_019912; Note=No experimental confirmation available.; |
| Catalytic Activity | Acetyl-CoA + 1-alkyl-sn-glycero-3- phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3- phosphocholine. |
| Catalytic Activity | Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine. |
| Catalytic Activity | Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. |
| Domain | The HXXXXD motif is essential for acyltransferase activity. |
| Enzyme Regulation | Acetyltransferase activity is increased following acute inflammatory stimulation by lipopolysaccharide (LPS). Acyltransferase activity is unchanged (By similarity). |
| Function | Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet- activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso- PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3- phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2- diacyl-sn-glycero-3-phosphocholine. {ECO |
| Pathway | Lipid metabolism; phospholipid metabolism. |
| Sequence Caution | Sequence=BAA91199.1; Type=Frameshift; Positions=44; Evidence= ; Sequence=CAE46034.1; Type=Frameshift; Positions=295; Evidence= ; |
| Similarity | Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. |
| Similarity | Contains 2 EF-hand domains. {ECO |
| Subcellular Location | Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus membrane {ECO |
Identical and Related Proteins
Unique RefSeq proteins for LMP006725 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 47086907 | RefSeq | NP_060309 | 544 | lysophosphatidylcholine acyltransferase 2 |
Identical Sequences to LMP006725 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:47086907 | EMBL | CCF76984.1 | 544 | unnamed protein product [Homo sapiens] |
| GI:47086907 | GenBank | ACE86445.1 | 544 | lysophosphatidylcholine acyltransferase 2 protein, partial [synthetic construct] |
| GI:47086907 | GenBank | ACE87121.1 | 544 | lysophosphatidylcholine acyltransferase 2 protein [synthetic construct] |
| GI:47086907 | GenBank | ADA18402.1 | 544 | Sequence 226 from patent US 7608413 |
| GI:47086907 | GenBank | AEN34298.1 | 544 | Sequence 226 from patent US 7998689 |
| GI:47086907 | GenBank | AIC51681.1 | 544 | LPCAT2, partial [synthetic construct] |
Related Sequences to LMP006725 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:47086907 | EMBL | CAD35462.1 | 544 | unnamed protein product, partial [Homo sapiens] |
| GI:47086907 | GenBank | ABI05830.1 | 544 | Sequence 7 from patent US 7078205 |
| GI:47086907 | GenBank | EAW82829.1 | 544 | acyltransferase like 1 [Homo sapiens] |
| GI:47086907 | GenBank | ABW41250.1 | 544 | Sequence 7 from patent US 7256010 |
| GI:47086907 | GenBank | ADA18401.1 | 544 | Sequence 225 from patent US 7608413 |
| GI:47086907 | GenBank | AEN34297.1 | 544 | Sequence 225 from patent US 7998689 |