Gene/Proteome Database (LMPD)

LMPD ID
LMP006728
Gene ID
79966
Species
Homo sapiens (Human)
Gene Name
stearoyl-CoA desaturase 5
Gene Symbol
SCD5
Synonyms
ACOD4; FADS4; HSCD5; SCD2; SCD4
Alternate Names
stearoyl-CoA desaturase 5; acyl-CoA-desaturase 4; stearoyl-CoA 9-desaturase; stearoyl-CoA desaturase 4
Chromosome
4
Map Location
4q21.22
EC Number
1.14.19.1
Summary
Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008]
Orthologs
View orthologs and multiple alignments for SCD5

Proteins

stearoyl-CoA desaturase 5 isoform a
Refseq ID NP_001032671
Protein GI 148596961
UniProt ID Q86SK9
mRNA ID NM_001037582
Length 330
RefSeq Status VALIDATED
MPGPATDAGKIPFCDAKEEIRAGLESSEGGGGPERPGARGQRQNIVWRNVVLMSLLHLGAVYSLVLIPKAKPLTLLWAYFCFLLAALGVTAGAHRLWSHRSYRAKLPLRIFLAVANSMAFQNDIFEWSRDHRAHHKYSETDADPHNARRGFFFSHIGWLFVRKHRDVIEKGRKLDVTDLLADPVVRIQRKYYKISVVLMCFVVPTLVPWYIWGESLWNSYFLASILRYTISLNISWLVNSAAHMYGNRPYDKHISPRQNPLVALGAIGEGFHNYHHTFPFDYSASEFGLNFNPTTWFIDFMCWLGLATDRKRATKPMIEARKARTGDSSA
stearoyl-CoA desaturase 5 isoform b
Refseq ID NP_079182
Protein GI 148596938
UniProt ID Q86SK9
mRNA ID NM_024906
Length 256
RefSeq Status VALIDATED
MPGPATDAGKIPFCDAKEEIRAGLESSEGGGGPERPGARGQRQNIVWRNVVLMSLLHLGAVYSLVLIPKAKPLTLLWAYFCFLLAALGVTAGAHRLWSHRSYRAKLPLRIFLAVANSMAFQNDIFEWSRDHRAHHKYSETDADPHNARRGFFFSHIGWLFVRKHRDVIEKGRKLDVTDLLADPVVRIQRNTQHIQKEGRALNQEAACEMLREWHQGHILKVTLPGLHILALLHTHCNHSEKCCLMLRALSVSLEVF

Gene Information

Entrez Gene ID
79966
Gene Name
stearoyl-CoA desaturase 5
Gene Symbol
SCD5
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005506 IEA:InterPro F iron ion binding
GO:0004768 IEA:UniProtKB-EC F stearoyl-CoA 9-desaturase activity
GO:0006633 IEA:UniProtKB-KW P fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04152 AMPK signaling pathway
hsa01040 Biosynthesis of unsaturated fatty acids
hsa03320 PPAR signaling pathway

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5996 oleate biosynthesis II (animals)

Domain Information

InterPro Annotations

Accession Description
IPR005804 Fatty acid desaturase, type 1
IPR001522 Fatty acid desaturase, type 1, C-terminal
IPR015876 Fatty acid desaturase, type 1, core

UniProt Annotations

Entry Information

Gene Name
stearoyl-CoA desaturase 5
Protein Entry
SCD5_HUMAN
UniProt ID
Q86SK9
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q86SK9-1; Sequence=Displayed; Name=2; IsoId=Q86SK9-2; Sequence=VSP_029883; Note=No experimental confirmation available.;
Catalytic Activity Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O.
Cofactor Name=Fe cation; Xref=ChEBI
Domain The histidine box domains may contain the active site and/or be involved in metal ion binding.
Function Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9 position.
Similarity Belongs to the fatty acid desaturase family.
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue Specificity Detected in fetal brain, and at lower levels in fetal kidney. Detected in adult brain and pancreas, and at lower levels in kidney and lung. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP006728 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
148596961 RefSeq NP_001032671 330 stearoyl-CoA desaturase 5 isoform a
148596938 RefSeq NP_079182 256 stearoyl-CoA desaturase 5 isoform b

Identical Sequences to LMP006728 proteins

Reference Database Accession Length Protein Name
GI:148596938 GenBank AAY40977.1 256 unknown [Homo sapiens]
GI:148596938 GenBank EAX05903.1 256 stearoyl-CoA desaturase 5, isoform CRA_b [Homo sapiens]
GI:148596961 GenBank AAI37430.1 330 Stearoyl-CoA desaturase 5 [Homo sapiens]
GI:148596961 GenBank AAI37433.1 330 Stearoyl-CoA desaturase 5 [Homo sapiens]
GI:148596961 GenBank ACH36748.1 330 Sequence 8 from patent US 7411054
GI:148596961 GenBank ACK08920.1 330 Sequence 2 from patent US 7435559
GI:148596961 GenBank ADM05331.1 330 Sequence 8 from patent US 7732182
GI:148596961 RefSeq XP_003832304.1 330 PREDICTED: stearoyl-CoA desaturase 5 isoform X1 [Pan paniscus]

Related Sequences to LMP006728 proteins

Reference Database Accession Length Protein Name
GI:148596938 DBBJ BAB14961.1 256 unnamed protein product [Homo sapiens]
GI:148596961 GenBank AAP31443.1 330 acyl-CoA-desaturase [Homo sapiens]
GI:148596938 GenBank ADR97007.1 256 Sequence 471 from patent US 7749695
GI:148596961 GenBank JAA25261.1 330 stearoyl-CoA desaturase 5 [Pan troglodytes]
GI:148596961 GenBank JAA33210.1 330 stearoyl-CoA desaturase 5 [Pan troglodytes]
GI:148596961 GenBank AHD73905.1 330 Sequence 12363 from patent US 8586006
GI:148596938 GenBank AHD76600.1 256 Sequence 20394 from patent US 8586006
GI:148596961 RefSeq XP_001141318.1 330 PREDICTED: stearoyl-CoA desaturase 5 isoform X1 [Pan troglodytes]
GI:148596938 RefSeq XP_517188.2 256 PREDICTED: stearoyl-CoA desaturase 5 isoform X2 [Pan troglodytes]
GI:148596938 RefSeq XP_004038944.1 256 PREDICTED: stearoyl-CoA desaturase 5 [Gorilla gorilla gorilla]
GI:148596938 RefSeq XP_008955892.1 256 PREDICTED: stearoyl-CoA desaturase 5 isoform X2 [Pan paniscus]
GI:148596961 RefSeq XP_010357232.1 330 PREDICTED: stearoyl-CoA desaturase 5 [Rhinopithecus roxellana]