Gene/Proteome Database (LMPD)

LMPD ID
LMP006729
Gene ID
5733
Species
Homo sapiens (Human)
Gene Name
prostaglandin E receptor 3 (subtype EP3)
Gene Symbol
PTGER3
Synonyms
EP3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3e; PGE2-R
Alternate Names
prostaglandin E2 receptor EP3 subtype; prostanoid EP3 receptor; PGE receptor, EP3 subtype; PGE2 receptor EP3 subtype; prostaglandin receptor (PGE-2); prostaglandin E receotor EP3 subtype 3 isoform
Chromosome
1
Map Location
1p31.2
Summary
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Orthologs
View orthologs and multiple alignments for PTGER3

Proteins

prostaglandin E2 receptor EP3 subtype isoform 4
Refseq ID NP_001119516
Protein GI 186659506
UniProt ID P43115
mRNA ID NM_001126044
Length 390
RefSeq Status REVIEWED
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
prostaglandin E2 receptor EP3 subtype isoform 4
Refseq ID NP_942007
Protein GI 38505178
UniProt ID P43115
mRNA ID NM_198714
Length 390
RefSeq Status REVIEWED
Protein sequence is identical to GI:186659506 (mRNA isoform)
prostaglandin E2 receptor EP3 subtype isoform 4
Refseq ID NP_942012
Protein GI 38505188
UniProt ID P43115
mRNA ID NM_198719
Length 390
RefSeq Status REVIEWED
Protein sequence is identical to GI:186659506 (mRNA isoform)
prostaglandin E2 receptor EP3 subtype isoform 5
Refseq ID NP_942008
Protein GI 38505180
UniProt ID P43115
mRNA ID NM_198715
Length 388
RefSeq Status REVIEWED
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQVANAVSSCSNDGQKGQPISLSNEIIQTEA
prostaglandin E2 receptor EP3 subtype isoform 6
Refseq ID NP_942009
Protein GI 38505182
UniProt ID P43115
mRNA ID NM_198716
Length 374
RefSeq Status REVIEWED
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQMRKRRLREQEEFWGN
prostaglandin E2 receptor EP3 subtype isoform 7
Refseq ID NP_942010
Protein GI 38505184
UniProt ID P43115
mRNA ID NM_198717
Length 365
RefSeq Status REVIEWED
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQEEFWGN
prostaglandin E2 receptor EP3 subtype isoform 8
Refseq ID NP_942011
Protein GI 38505186
UniProt ID O00325
mRNA ID NM_198718
Length 418
RefSeq Status REVIEWED
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQMRKRRLREQLICSLQNSQIQRATAHCGQVQTYRVLNREEMEVLVSSINVYTRISTVKTE

Gene Information

Entrez Gene ID
5733
Gene Name
prostaglandin E receptor 3 (subtype EP3)
Gene Symbol
PTGER3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 NAS:UniProtKB C integral component of membrane
GO:0004957 NAS:UniProtKB F prostaglandin E receptor activity

KEGG Pathway Links

KEGG Pathway ID Description
hsa04020 Calcium signaling pathway
hsa04024 cAMP signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR001244 Prostaglandin DP receptor
IPR000265 Prostanoid EP3 receptor
IPR001481 Prostanoid EP3 receptor, type 2
IPR008365 Prostanoid receptor

UniProt Annotations

Entry Information

Gene Name
prostaglandin E receptor 3 (subtype EP3)
Protein Entry
PE2R3_HUMAN
UniProt ID
P43115
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=11; Comment=Additional isoforms seem to exist.; Name=EP3A; Synonyms=EP3-I, EP3a1, EP3a2, EP(3-Ic); IsoId=P43115-1; Sequence=Displayed; Name=EP3C; Synonyms=EP3-II; IsoId=P43115-2; Sequence=VSP_001935; Note=Known as EP3D in PubMed:8075855.; Name=EP3B; Synonyms=EP3-III; IsoId=P43115-3; Sequence=VSP_001936; Note=Known as EP3E in PubMed:8075855.; Name=EP3D; Synonyms=EP3-IV; IsoId=P43115-4; Sequence=VSP_001937; Note=Known as EP3F in PubMed:8075855.; Name=EP3E; IsoId=P43115-5; Sequence=VSP_001938; Name=EP3F; IsoId=P43115-6; Sequence=VSP_001939; Name=EP3G; IsoId=P43115-7; Sequence=VSP_013271; Name=EP3-III; IsoId=P43115-8; Sequence=VSP_053774; Name=EP3-IV; IsoId=P43115-9; Sequence=VSP_053775; Name=EP3-V; IsoId=P43115-10; Sequence=VSP_053776; Name=EP3E2; IsoId=P43115-11; Sequence=VSP_053777;
Function Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity). {ECO:0000250}.
Sequence Caution Sequence=CAA58742.1; Type=Frameshift; Positions=374; Evidence={ECO:0000305};
Similarity Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels. {ECO:0000269|PubMed:18023986}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006729 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
186659506 RefSeq NP_001119516 390 prostaglandin E2 receptor EP3 subtype isoform 4
38505180 RefSeq NP_942008 388 prostaglandin E2 receptor EP3 subtype isoform 5
38505182 RefSeq NP_942009 374 prostaglandin E2 receptor EP3 subtype isoform 6
38505184 RefSeq NP_942010 365 prostaglandin E2 receptor EP3 subtype isoform 7
38505186 RefSeq NP_942011 418 prostaglandin E2 receptor EP3 subtype isoform 8

Identical Sequences to LMP006729 proteins

Reference Database Accession Length Protein Name
GI:38505184 DBBJ BAG70295.1 365 prostaglandin E receotor EP3 subtype 3 isoform, partial [Homo sapiens]
GI:38505180 EMBL CAE83498.1 388 unnamed protein product [Homo sapiens]
GI:38505180 EMBL CCF77031.1 388 unnamed protein product [Homo sapiens]
GI:38505182 EMBL CCF77032.1 374 unnamed protein product [Homo sapiens]
GI:38505184 EMBL CCF77033.1 365 unnamed protein product [Homo sapiens]
GI:38505186 EMBL CCF77034.1 418 unnamed protein product [Homo sapiens]
GI:186659506 EMBL CCF77036.1 390 unnamed protein product [Homo sapiens]
GI:38505180 GenBank AAE62629.1 388 Sequence 6 from patent US 6197933
GI:38505180 GenBank AAS24980.1 388 Sequence 6 from patent US 6670134
GI:38505184 GenBank AAS24981.1 365 Sequence 8 from patent US 6670134
GI:38505180 GenBank EAX06437.1 388 prostaglandin E receptor 3 (subtype EP3), isoform CRA_b [Homo sapiens]
GI:38505182 GenBank ADQ32123.1 374 prostaglandin E receptor 3 (subtype EP3), partial [synthetic construct]
GI:186659506 GenBank AHD80159.1 390 Sequence 31624 from patent US 8586006
GI:38505180 GenBank AHD80160.1 388 Sequence 31625 from patent US 8586006
GI:38505182 GenBank AHD80161.1 374 Sequence 31626 from patent US 8586006
GI:38505184 GenBank AHD80162.1 365 Sequence 31627 from patent US 8586006
GI:38505186 GenBank AHD80163.1 418 Sequence 31628 from patent US 8586006
GI:186659506 GenBank AHD80164.1 390 Sequence 31629 from patent US 8586006
GI:186659506 GenBank AHD80165.1 390 Sequence 31630 from patent US 8586006
GI:38505182 GenBank AIC63132.1 374 PTGER3, partial [synthetic construct]
GI:38505182 RefSeq XP_003308191.1 374 PREDICTED: prostaglandin E2 receptor EP3 subtype isoform X6 [Pan troglodytes]
GI:38505184 RefSeq XP_003308193.1 365 PREDICTED: prostaglandin E2 receptor EP3 subtype isoform X7 [Pan troglodytes]
GI:38505182 RefSeq XP_003830640.1 374 PREDICTED: prostaglandin E2 receptor EP3 subtype isoform X6 [Pan paniscus]
GI:38505184 RefSeq XP_003830641.1 365 PREDICTED: prostaglandin E2 receptor EP3 subtype isoform X7 [Pan paniscus]
GI:186659506 RefSeq XP_003830642.1 390 PREDICTED: prostaglandin E2 receptor EP3 subtype isoform X5 [Pan paniscus]
GI:186659506 RefSeq XP_003830647.1 390 PREDICTED: prostaglandin E2 receptor EP3 subtype isoform X5 [Pan paniscus]

Related Sequences to LMP006729 proteins

Reference Database Accession Length Protein Name
GI:38505180 DBBJ BAA19949.1 419 EP3-I [Homo sapiens]
GI:38505180 DBBJ BAA19950.1 419 EP3-I [Homo sapiens]
GI:38505180 DBBJ BAA19953.1 422 EP3-VI [Homo sapiens]
GI:38505180 DBBJ BAA19954.1 422 EP3e [Homo sapiens]
GI:38505180 DBBJ BAA19957.1 403 EP3-IV [Homo sapiens]
GI:186659506 DBBJ BAF83323.1 390 unnamed protein product [Homo sapiens]
GI:38505186 EMBL CAA58742.1 393 prostaglandin E receptor, subtype EP3e [Homo sapiens]
GI:38505186 EMBL CAE83504.1 393 unnamed protein product [Homo sapiens]
GI:38505182 EMBL CCF77028.1 402 unnamed protein product [Homo sapiens]
GI:38505184 EMBL CCF77032.1 374 unnamed protein product [Homo sapiens]
GI:38505182 GenBank AAA21130.1 374 protaglandin receptor EP3F [Homo sapiens]
GI:38505184 GenBank AAA21131.1 365 protaglandin receptor EP3E [Homo sapiens]
GI:186659506 GenBank AAA21132.1 390 protaglandin receptor EP3A1 [Homo sapiens]
GI:186659506 GenBank AAA21134.1 390 protaglandin receptor EP3A [Homo sapiens]
GI:186659506 GenBank AAB30208.1 390 prostaglandin E receptor EP3 subtype [Homo sapiens]
GI:186659506 GenBank AAE62631.1 390 Sequence 17 from patent US 6197933
GI:38505184 GenBank AAH24229.1 374 Prostaglandin E receptor 3 (subtype EP3) [Homo sapiens]
GI:186659506 GenBank AAS24982.1 390 Sequence 17 from patent US 6670134
GI:38505182 GenBank EAX06442.1 402 prostaglandin E receptor 3 (subtype EP3), isoform CRA_g [Homo sapiens]
GI:38505180 GenBank EAX06444.1 419 prostaglandin E receptor 3 (subtype EP3), isoform CRA_i, partial [Homo sapiens]
GI:38505184 GenBank ADQ32123.1 374 prostaglandin E receptor 3 (subtype EP3), partial [synthetic construct]
GI:38505184 GenBank AIC63132.1 374 PTGER3, partial [synthetic construct]
GI:38505186 RefSeq XP_002810749.1 418 PREDICTED: prostaglandin E2 receptor EP3 subtype isoform X3 [Pongo abelii]
GI:38505184 RefSeq XP_002810750.1 365 PREDICTED: prostaglandin E2 receptor EP3 subtype isoform X8 [Pongo abelii]
GI:38505182 RefSeq XP_002810751.1 374 PREDICTED: prostaglandin E2 receptor EP3 subtype isoform X7 [Pongo abelii]
GI:38505182 RefSeq XP_003260239.1 374 PREDICTED: prostaglandin E2 receptor EP3 subtype isoform 2 [Nomascus leucogenys]
GI:38505186 RefSeq XP_003308196.1 418 PREDICTED: prostaglandin E2 receptor EP3 subtype isoform X2 [Pan troglodytes]
GI:38505186 RefSeq XP_003830646.1 418 PREDICTED: prostaglandin E2 receptor EP3 subtype isoform X2 [Pan paniscus]
GI:38505182 RefSeq XP_004026022.1 374 PREDICTED: prostaglandin E2 receptor EP3 subtype isoform 2 [Gorilla gorilla gorilla]
GI:38505186 RefSeq XP_004026025.1 418 PREDICTED: prostaglandin E2 receptor EP3 subtype isoform 5 [Gorilla gorilla gorilla]