Gene/Proteome Database (LMPD)

LMPD ID
LMP006730
Gene ID
9754
Species
Homo sapiens (Human)
Gene Name
StAR-related lipid transfer (START) domain containing 8
Gene Symbol
STARD8
Synonyms
ARHGAP38; DLC3; STARTGAP3
Alternate Names
stAR-related lipid transfer protein 8; START domain containing 8; deleted in liver cancer 3 protein
Chromosome
X
Map Location
Xq13.1
Summary
This gene encodes a member of a subfamily of Rho GTPase activating proteins that contain a steroidogenic acute regulatory protein related lipid transfer domain. The encoded protein localizes to focal adhesions and may be involved in regulating cell morphology. This protein may also function as a tumor suppressor. [provided by RefSeq, Mar 2010]
Orthologs
View orthologs and multiple alignments for STARD8

Proteins

stAR-related lipid transfer protein 8 isoform a
Refseq ID NP_001135975
Protein GI 215820650
UniProt ID Q92502
mRNA ID NM_001142503
Length 1103
RefSeq Status REVIEWED
MPLLDVFWSCFRKVKCFPLLQVKKNAEAEAKRACEWLQATGFPQYVQLFEEGSFPLDIGSVKKNHGFLDEDSLGALCRRLMTLNNCASMKLEVHFQSKQNEDSEEEEQCTISSHWAFQQESKCWSPMGSSDLLAPPSPGLPATSSCESVLTELSATSLPVITVSLPPEPADLPLPGRAPSSSDRPLLSPTQGQEGPQDKAKKRHRNRSFLKHLESLRRKEKSGSQQAEPKHSPATSEKVSKASSFRSCRGFLSAGFYRAKNWAATSAGGSGANTRKAWEAWPVASFRHPQWTHRGDCLVHVPGDHKPGTFPRSLSIESLCPEDGHRLADWQPGRRWGCEGRRGSCGSTGSHASTYDNLPELYPAEPVMVGAEAEDEDDEESGGSYAHLDDILQHVWGLQQRVELWSRAMYPDLGPGDEEEEEATSSVEIATVEVKCQAEALSQMEVPAHGESPAWAQAEVQPAVLAPAQAPAEAEPVAQEEAEAPAPAPAPAPAQDSEQEAHSGGEPTFASSLSVEEGHSISDTVASSSELDSSGNSMNEAEAAGPLAGLQASMPRERRDSGVGASLTRPCRKLRWHSFQNSHRPSLNSESLEINRQFAGQINLLHKGSLLRLTAFMEKYTVPHKQGWVWSMPKFMRRNKTPDYRGQHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQCLDQVGIFRKSGVKSRIQNLRQMNETSPDNVCYEGQSAYDVADLLKQYFRDLPEPIFTSKLTTTFLQIYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFLSDIASAEENQMTAGNLAVCLAPSIFHLNVSKKDSPSPRIKSKRSLIGRPGPRDLSDNMAATQGLSHMISDCKKLFQVPQDMVLQLCSSYSAAELSPPGPALAELRQAQAAGVSLSLYMEENIQDLLRDAAERFKGWMSVPGPQHTELACRKAPDGHPLRLWKASTEVAAPPAVVLHRVLRERALWDEDLLRAQVLEALMPGVELYHYVTDSMAPHPCRDFVVLRMWRSDLPRGGCLLVSQSLDPEQPVPESGVRALMLTSQYLMEPCGLGRSRLTHICRADLRGRSPDWYNKVFGHLCAMEVAKIRDSFPTLQAAGPETKL
stAR-related lipid transfer protein 8 isoform b
Refseq ID NP_001135976
Protein GI 215820652
UniProt ID Q92502
mRNA ID NM_001142504
Length 1023
RefSeq Status REVIEWED
MTLNNCASMKLEVHFQSKQNEDSEEEEQCTISSHWAFQQESKCWSPMGSSDLLAPPSPGLPATSSCESVLTELSATSLPVITVSLPPEPADLPLPGRAPSSSDRPLLSPTQGQEGPQDKAKKRHRNRSFLKHLESLRRKEKSGSQQAEPKHSPATSEKVSKASSFRSCRGFLSAGFYRAKNWAATSAGGSGANTRKAWEAWPVASFRHPQWTHRGDCLVHVPGDHKPGTFPRSLSIESLCPEDGHRLADWQPGRRWGCEGRRGSCGSTGSHASTYDNLPELYPAEPVMVGAEAEDEDDEESGGSYAHLDDILQHVWGLQQRVELWSRAMYPDLGPGDEEEEEATSSVEIATVEVKCQAEALSQMEVPAHGESPAWAQAEVQPAVLAPAQAPAEAEPVAQEEAEAPAPAPAPAPAQDSEQEAHSGGEPTFASSLSVEEGHSISDTVASSSELDSSGNSMNEAEAAGPLAGLQASMPRERRDSGVGASLTRPCRKLRWHSFQNSHRPSLNSESLEINRQFAGQINLLHKGSLLRLTAFMEKYTVPHKQGWVWSMPKFMRRNKTPDYRGQHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQCLDQVGIFRKSGVKSRIQNLRQMNETSPDNVCYEGQSAYDVADLLKQYFRDLPEPIFTSKLTTTFLQIYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFLSDIASAEENQMTAGNLAVCLAPSIFHLNVSKKDSPSPRIKSKRSLIGRPGPRDLSDNMAATQGLSHMISDCKKLFQVPQDMVLQLCSSYSAAELSPPGPALAELRQAQAAGVSLSLYMEENIQDLLRDAAERFKGWMSVPGPQHTELACRKAPDGHPLRLWKASTEVAAPPAVVLHRVLRERALWDEDLLRAQVLEALMPGVELYHYVTDSMAPHPCRDFVVLRMWRSDLPRGGCLLVSQSLDPEQPVPESGVRALMLTSQYLMEPCGLGRSRLTHICRADLRGRSPDWYNKVFGHLCAMEVAKIRDSFPTLQAAGPETKL
stAR-related lipid transfer protein 8 isoform b
Refseq ID NP_055540
Protein GI 31543659
UniProt ID Q92502
mRNA ID NM_014725
Length 1023
RefSeq Status REVIEWED
Protein sequence is identical to GI:215820652 (mRNA isoform)

Gene Information

Entrez Gene ID
9754
Gene Name
StAR-related lipid transfer (START) domain containing 8
Gene Symbol
STARD8
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030054 IEA:UniProtKB-KW C cell junction
GO:0005829 TAS:Reactome C cytosol
GO:0005096 IEA:UniProtKB-KW F GTPase activator activity
GO:0008289 IEA:InterPro F lipid binding
GO:0051056 TAS:Reactome P regulation of small GTPase mediated signal transduction
GO:0007264 TAS:Reactome P small GTPase mediated signal transduction

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_11051 Rho GTPase cycle
REACT_11044 Signaling by Rho GTPases
REACT_111102 Signal Transduction

Domain Information

InterPro Annotations

Accession Description
IPR000198 Rho GTPase-activating protein domain
IPR008936 Rho GTPase activation protein
IPR023393 START-like domain
IPR002913 START_lipid-bd_dom

UniProt Annotations

Entry Information

Gene Name
StAR-related lipid transfer (START) domain containing 8
Protein Entry
STAR8_HUMAN
UniProt ID
Q92502
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=DLC3beta; IsoId=Q92502-1; Sequence=Displayed; Name=2; Synonyms=DLC3alpha; IsoId=Q92502-2; Sequence=VSP_032984; Note=Ref.3 (CAH18253) sequence is in conflict in position: 71:D->G. No experimental confirmation available. ;
Function Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5- bisphosphate by PLCD1.
Sequence Caution Sequence=BAA11506.2; Type=Erroneous initiation; Evidence= ;
Similarity Contains 1 Rho-GAP domain. {ECO
Similarity Contains 1 START domain. {ECO
Subcellular Location Cell junction, focal adhesion .
Subunit Binds both the SH2 and PTB domains of TNS1.
Tissue Specificity Widely expressed with highest levels in kidney, lung and placenta.

Identical and Related Proteins

Unique RefSeq proteins for LMP006730 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
215820650 RefSeq NP_001135975 1103 stAR-related lipid transfer protein 8 isoform a
215820652 RefSeq NP_001135976 1023 stAR-related lipid transfer protein 8 isoform b

Identical Sequences to LMP006730 proteins

Reference Database Accession Length Protein Name
GI:215820652 DBBJ BAF84436.1 1023 unnamed protein product [Homo sapiens]
GI:215820652 GenBank EAX05374.1 1023 START domain containing 8, isoform CRA_a [Homo sapiens]
GI:215820652 GenBank EAX05375.1 1023 START domain containing 8, isoform CRA_a [Homo sapiens]
GI:215820652 GenBank AIC50426.1 1023 STARD8, partial [synthetic construct]
GI:215820652 RefSeq NP_055540.2 1023 stAR-related lipid transfer protein 8 isoform b [Homo sapiens]
GI:215820652 SwissProt Q92502.2 1023 RecName: Full=StAR-related lipid transfer protein 8; AltName: Full=Deleted in liver cancer 3 protein; Short=DLC-3; AltName: Full=START domain-containing protein 8; Short=StARD8; AltName: Full=START-GAP3 [Homo sapiens]

Related Sequences to LMP006730 proteins

Reference Database Accession Length Protein Name
GI:215820650 DBBJ BAA11506.2 1132 KIAA0189, partial [Homo sapiens]
GI:215820652 DBBJ BAA11506.2 1132 KIAA0189, partial [Homo sapiens]
GI:215820652 DBBJ BAG10301.1 1023 START domain-containing protein 8, partial [synthetic construct]
GI:215820650 EMBL CAH18253.1 1103 hypothetical protein [Homo sapiens]
GI:215820652 EMBL CAH18253.1 1103 hypothetical protein [Homo sapiens]
GI:215820652 GenBank ABM81843.1 1023 START domain containing 8 [synthetic construct]
GI:215820650 GenBank JAA42808.1 1103 StAR-related lipid transfer (START) domain containing 8 [Pan troglodytes]
GI:215820652 RefSeq NP_001135975.1 1103 stAR-related lipid transfer protein 8 isoform a [Homo sapiens]
GI:215820652 RefSeq XP_003816948.1 1103 PREDICTED: stAR-related lipid transfer protein 8 isoform X2 [Pan paniscus]
GI:215820650 RefSeq XP_003816948.1 1103 PREDICTED: stAR-related lipid transfer protein 8 isoform X2 [Pan paniscus]
GI:215820650 RefSeq XP_005262371.1 1107 PREDICTED: stAR-related lipid transfer protein 8 isoform X1 [Homo sapiens]
GI:215820650 RefSeq XP_008968253.1 1107 PREDICTED: stAR-related lipid transfer protein 8 isoform X1 [Pan paniscus]