Gene/Proteome Database (LMPD)
LMPD ID
LMP006734
Gene ID
Species
Homo sapiens (Human)
Gene Name
diacylglycerol kinase, iota
Gene Symbol
Synonyms
DGK-IOTA
Alternate Names
diacylglycerol kinase iota; DAG kinase iota; diglyceride kinase iota
Chromosome
7
Map Location
7q32.3-q33
EC Number
2.7.1.107
Summary
This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| diacylglycerol kinase iota | |
|---|---|
| Refseq ID | NP_004708 |
| Protein GI | 4758156 |
| UniProt ID | O75912 |
| mRNA ID | NM_004717 |
| Length | 1065 |
| RefSeq Status | REVIEWED |
| MDAAGRGCHLLPLPAARGPARAPAAAAAAAASPPGPCSGAACAPSAAAGAGAMNPSSSAGEEKGATGGSSSSGSGAGSCCLGAEGGADPRGAGSAAAAGAAALDEPAAAGQKEKDEALEEKLRNLTFRKQVSYRKAISRAGLQHLAPAHPLSLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDPQSVPDRLRIRVNKISLQDYEGFHYDKEKLREASISDWLRTIAGELVQSFGAIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDHETSFPRALSAQRLSPRWCFLDDRSQEHLHFVMEISQDEIFILDPDMVVSQPAGTPPGMPDLVVEQASGISDWWNPALRKRMLSDSGLGMIAPYYEDSDLKDLSHSRVLQSPVSSEDHAILQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDLAAYLESRQNYKVIGHEDLETAV | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | TAS:ProtInc | C | cytoplasm |
| GO:0032045 | IEA:Ensembl | C | guanyl-nucleotide exchange factor complex |
| GO:0005634 | IDA:HPA | C | nucleus |
| GO:0048471 | IEA:Ensembl | C | perinuclear region of cytoplasm |
| GO:0005886 | TAS:Reactome | C | plasma membrane |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0005095 | IEA:Ensembl | F | GTPase inhibitor activity |
| GO:0003951 | IEA:InterPro | F | NAD+ kinase activity |
| GO:0004143 | TAS:ProtInc | F | diacylglycerol kinase activity |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0007596 | TAS:Reactome | P | blood coagulation |
| GO:0035556 | IEA:InterPro | P | intracellular signal transduction |
| GO:0030168 | TAS:Reactome | P | platelet activation |
| GO:0046579 | IEA:Ensembl | P | positive regulation of Ras protein signal transduction |
| GO:0007205 | IEA:InterPro | P | protein kinase C-activating G-protein coupled receptor signaling pathway |
| GO:0032317 | IEA:Ensembl | P | regulation of Rap GTPase activity |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00561 | Glycerolipid metabolism |
| hsa00564 | Glycerophospholipid metabolism |
| hsa01100 | Metabolic pathways |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_19184 | GPCR downstream signaling |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR016064 | ATP-NAD kinase-like domain |
| IPR002110 | Ankyrin repeat |
| IPR020683 | Ankyrin repeat-containing domain |
| IPR000756 | Diacylglycerol kinase, accessory domain |
| IPR001206 | Diacylglycerol kinase, catalytic domain |
| IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate. |
| Interaction | P40337-3:VHL; NbExp=3; IntAct=EBI-1765520, EBI-301270; |
| Similarity | Belongs to the eukaryotic diacylglycerol kinase family. |
| Similarity | Contains 1 DAGKc domain. {ECO |
| Similarity | Contains 2 ANK repeats. {ECO |
| Similarity | Contains 2 phorbol-ester/DAG-type zinc fingers. |
| Subcellular Location | Cytoplasm. Nucleus. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006734 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4758156 | RefSeq | NP_004708 | 1065 | diacylglycerol kinase iota |
Identical Sequences to LMP006734 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4758156 | GenBank | AAE75298.1 | 1065 | Sequence 2 from patent US 6255095 |
| GI:4758156 | GenBank | EAL24051.1 | 1065 | diacylglycerol kinase, iota [Homo sapiens] |
| GI:4758156 | GenBank | ABA36673.1 | 1065 | Sequence 239 from patent US 6936450 |
| GI:4758156 | GenBank | ACM81043.1 | 1065 | Sequence 6541 from patent US 6812339 |
| GI:4758156 | GenBank | AHD73773.1 | 1065 | Sequence 12231 from patent US 8586006 |
| GI:4758156 | SwissProt | O75912.1 | 1065 | RecName: Full=Diacylglycerol kinase iota; Short=DAG kinase iota; AltName: Full=Diglyceride kinase iota; Short=DGK-iota [Homo sapiens] |
Related Sequences to LMP006734 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4758156 | RefSeq | XP_001107030.1 | 1066 | PREDICTED: diacylglycerol kinase iota [Macaca mulatta] |
| GI:4758156 | RefSeq | XP_005550934.1 | 1066 | PREDICTED: diacylglycerol kinase iota isoform X1 [Macaca fascicularis] |
| GI:4758156 | RefSeq | XP_006716235.1 | 1057 | PREDICTED: diacylglycerol kinase iota isoform X1 [Homo sapiens] |
| GI:4758156 | RefSeq | XP_007981244.1 | 1076 | PREDICTED: diacylglycerol kinase iota isoform X10 [Chlorocebus sabaeus] |
| GI:4758156 | RefSeq | XP_007981247.1 | 1056 | PREDICTED: diacylglycerol kinase iota isoform X13 [Chlorocebus sabaeus] |
| GI:4758156 | RefSeq | XP_007981253.1 | 1074 | PREDICTED: diacylglycerol kinase iota isoform X18 [Chlorocebus sabaeus] |