Gene/Proteome Database (LMPD)

LMPD ID
LMP006736
Gene ID
5287
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Gene Symbol
PIK3C2B
Synonyms
C2-PI3K
Chromosome
1
Map Location
1q32
Summary
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for PIK3C2B

Proteins

phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
Refseq ID NP_002637
Protein GI 194097347
UniProt ID O00750
mRNA ID NM_002646
Length 1634
RefSeq Status REVIEWED
MSSTQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHDKEENRAKQNADPSLISWDEPGVDFYSKPAGRRTDLKLLRGLSGSDPTLNYNSLSPQEGPPNHSTSQGPQPGSDPWPKGSLSGDYLYIFDGSDGGVSSSPGPGDIEGSCKKLSPPPLPPRASIWDTPPLPPRKGSPSSSKISQPSDINTFSLVEQLPGKLLEHRILEEEEVLGGGGQGRLLGSVDYDGINDAITRLNLKSTYDAEMLRDATRGWKEGRGPLDFSKDTSGKPVARSKTMPPQVPPRTYASRYGNRKNATPGKNRRISAAPVGSRPHTVANGHELFEVSEERDEEVAAFCHMLDILRSGSDIQDYFLTGYVWSAVTPSPEHLGDEVNLKVTVLCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHLQERPVKQTISRQALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPPCPSRMQPKIQKDPSVLAVRENREKVVEALTAAILDLVELYCNTFNADFQTAVPGSRKHDLVQEACHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSSSEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQENPSARWSAPNFHQPDSVILQIDFPTSAFDIKFTSPPGDKFSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLWEKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNFFIHNLAQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFHPNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGEAVAERRREELNGYIWHLIHAPPEVAECDLVYTFFHPLPRDEKAMGTSPAPKSSDGTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEKTGWFALGSRSHGTL

Gene Information

Entrez Gene ID
5287
Gene Name
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Gene Symbol
PIK3C2B
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030139 IEA:Ensembl C endocytic vesicle
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0001727 IEA:Ensembl F lipid kinase activity
GO:0035091 IEA:InterPro F phosphatidylinositol binding
GO:0016773 IEA:InterPro F phosphotransferase activity, alcohol group as acceptor
GO:0046854 IEA:InterPro P phosphatidylinositol phosphorylation
GO:0048015 IEA:InterPro P phosphatidylinositol-mediated signaling
GO:0043491 IEA:Ensembl P protein kinase B signaling

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121025 Synthesis of PIPs at the plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR000008 C2 domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR001683 Phox homologous domain
IPR011009 Protein kinase-like domain
IPR029071 Ubiquitin-related domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Protein Entry
P3C2B_HUMAN
UniProt ID
O00750
Species
Human

Comments

Comment Type Description
Similarity Contains 1 C2 domain.
Similarity Contains PI3K/PI4K domain.
Similarity Contains PIK helical domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP006736 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
194097347 RefSeq NP_002637 1634 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

Identical Sequences to LMP006736 proteins

Reference Database Accession Length Protein Name
GI:194097347 DBBJ BAG10256.1 1634 phosphoinositide-3-kinase, class 2, beta polypeptide, partial [synthetic construct]
GI:194097347 GenBank ABY87552.1 1634 phosphoinositide-3-kinase, class 2, beta polypeptide [Homo sapiens]
GI:194097347 GenBank AAI36646.1 1634 Phosphoinositide-3-kinase, class 2, beta polypeptide [Homo sapiens]
GI:194097347 GenBank AGC09602.1 1634 phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta [Homo sapiens]
GI:194097347 RefSeq XP_005245314.1 1634 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [Homo sapiens]
GI:194097347 RefSeq XP_006711447.1 1634 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X7 [Homo sapiens]

Related Sequences to LMP006736 proteins

Reference Database Accession Length Protein Name
GI:194097347 DBBJ BAE06088.1 1645 PIK3C2B variant protein, partial [Homo sapiens]
GI:194097347 EMBL CAA72168.1 1634 phosphoinositide 3-kinase [Homo sapiens]
GI:194097347 GenBank EAW91513.1 1637 phosphoinositide-3-kinase, class 2, beta polypeptide, isoform CRA_a [Homo sapiens]
GI:194097347 GenBank ACM85889.1 1650 Sequence 11387 from patent US 6812339
GI:194097347 GenBank ADC20197.1 1634 Sequence 418 from patent US 7638288
GI:194097347 GenBank AGD01158.1 1634 Sequence 418 from patent US 8338124