Gene/Proteome Database (LMPD)
LMPD ID
LMP006738
Gene ID
Species
Homo sapiens (Human)
Gene Name
oxysterol binding protein-like 6
Gene Symbol
Synonyms
ORP6
Alternate Names
oxysterol-binding protein-related protein 6; ORP-6; OSBP-related protein 6
Chromosome
2
Map Location
2q32.1
Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| oxysterol-binding protein-related protein 6 isoform a | |
|---|---|
| Refseq ID | NP_115912 |
| Protein GI | 14210532 |
| UniProt ID | Q9BZF3 |
| mRNA ID | NM_032523 |
| Length | 934 |
| RefSeq Status | REVIEWED |
| MSSDEKGISPAHKTSTPTHRSASSSTSSQRDSRQSIHILERTASSSTEPSVSRQLLEPEPVPLSKEADSWEIIEGLKIGQTNVQKPDKHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKSQDWFDAWVSKLRHHRLYRQNEIVRSPRDASFHIFPSTSTAESSPAANVSVMDGKMQPNSFPWQSPLPCSNSLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQNLEILQRTQSAPNFTDMQANCVDISKKDKRVTRRWRTKSVSKDTKIQLQVPFSATMSPVRLHSSNPNLCADIEFQTPPSHLTDPLESSTDYTKLQEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDHSKGHSTQMARLRQSLSQALNQNAELRSRLNRIHSESIICDQVVSVNIIPSPDEAGEQIHVSLPLSQQVANESRLSMSESVSEFFDAQEVLLSASSSENEASDDESYISDVSDNISEDNTSVADNISRQILNGELTGGAFRNGRRACLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVFWQDIRWKNKFWGKSMEILPVGTLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSVCICKLTFVKVNYWNSNMNEVQGVVIDQEGKAVYRLFGKWHEGLYCGVAPSAKCIWRPGSMPTNYELYYGFTRFAIELNELDPVLKDLLPPTDARFRPDQRFLEEGNLEAAASEKQRVEELQRSRRRYMEENNLEHIPKFFKKVIDANQREAWVSNDTYWELRKDPGFSKVDSPVLW | |
| oxysterol-binding protein-related protein 6 isoform b | |
|---|---|
| Refseq ID | NP_665682 |
| Protein GI | 22035612 |
| UniProt ID | Q9BZF3 |
| mRNA ID | NM_145739 |
| Length | 938 |
| RefSeq Status | REVIEWED |
| MHQLSLIRGNRGRSIHILERTASSSTEPSVSRQLLEPEPVPLSKEADSWEIIEGLKIGQTNVQKPDKHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKSQDWFDAWVSKLRHHRLYRQNEIVRSPRDASFHIFPSTSTAESSPAANVSVMDGKMQPNSFPWQSPLPCSNSLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQNLEILQRTQSAPNFTDMQANCVDISKKDKRVTRRWRTKSVSKDTKIQLQEGPPAKGQFSTTRRRQRLAAAVATTVPFSATMSPVRLHSSNPNLCADIEFQTPPSHLTDPLESSTDYTKLQEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDHSKGHSTQMARLRQSLSQALNQNAELRSRLNRIHSESIICDQVVSVNIIPSPDEAGEQIHVSLPLSQQVANESRLSMSESVSEFFDAQEVLLSASSSENEASDDESYISDVSDNISEDNTSVADNISRQILNGELTGGAFRNGRRACLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVFWQDIRWKNKFWGKSMEILPVGTLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSVCICKLTFVKVNYWNSNMNEVQGVVIDQEGKAVYRLFGKWHEGLYCGVAPSAKCIWRPGSMPTNYELYYGFTRFAIELNELDPVLKDLLPPTDARFRPDQRFLEEGNLEAAASEKQRVEELQRSRRRYMEENNLEHIPKFFKKVIDANQREAWVSNDTYWELRKDPGFSKVDSPVLW | |
| oxysterol-binding protein-related protein 6 isoform c | |
|---|---|
| Refseq ID | NP_001188409 |
| Protein GI | 319996735 |
| UniProt ID | Q9BZF3 |
| mRNA ID | NM_001201480 |
| Length | 959 |
| RefSeq Status | REVIEWED |
| MSSDEKGISPAHKTSTPTHRSASSSTSSQRDSRQSIHILERTASSSTEPSVSRQLLEPEPVPLSKEADSWEIIEGLKIGQTNVQKPDKHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKSQDWFDAWVSKLRHHRLYRQNEIVRSPRDASFHIFPSTSTAESSPAANVSVMDGKMQPNSFPWQSPLPCSNSLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQNLEILQRTQSAPNFTDMQANCVDISKKDKRVTRRWRTKSVSKDTKIQLQEGPPAKGQFSTTRRRQRLAAAVATTVPFSATMSPVRLHSSNPNLCADIEFQTPPSHLTDPLESSTDYTKLQEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDHSKGHSTQMARLRQSLSQALNQNAELRSRLNRIHSESIICDQVVSVNIIPSPDEAGEQIHVSLPLSQQVANESRLSMSESVSEFFDAQEVLLSASSSENEASDDESYISDVSDNISEDNTSVADNISRQILNGELTGGAFRNGRRACLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVFWQDIRWKNKFWGKSMEILPVGTLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSVCICKLTFVKVNYWNSNMNEVQGVVIDQEGKAVYRLFGKWHEGLYCGVAPSAKCIWRPGSMPTNYELYYGFTRFAIELNELDPVLKDLLPPTDARFRPDQRFLEEGNLEAAASEKQRVEELQRSRRRYMEENNLEHIPKFFKKVIDANQREAWVSNDTYWELRKDPGFSKVDSPVLW | |
| oxysterol-binding protein-related protein 6 isoform d | |
|---|---|
| Refseq ID | NP_001188410 |
| Protein GI | 319996735 |
| UniProt ID | Q9BZF3 |
| mRNA ID | NM_001201481 |
| Length | 959 |
| RefSeq Status | REVIEWED |
| MSSDEKGISPAHKTSTPTHRSASSSTSSQRDSRQSIHILERTASSSTEPSVSRQLLEPEPVPLSKEADSWEIIEGLKIGQTNVQKPDKHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKSQDWFDAWVSKLRHHRLYRQNEIVRSPRDASFHIFPSTSTAESSPAANVSVMDGKMQPNSFPWQSPLPCSNSLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQNLEILQRTQSAPNFTDMQANCVDISKKDKRVTRRWRTKSVSKDTKIQLQEGPPAKGQFSTTRRRQRLAAAVATTVPFSATMSPVRLHSSNPNLCADIEFQTPPSHLTDPLESSTDYTKLQEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDHSKGHSTQMARLRQSLSQALNQNAELRSRLNRIHSESIICDQVVSVNIIPSPDEAGEQIHVSLPLSQQVANESRLSMSESVSEFFDAQEVLLSASSSENEASDDESYISDVSDNISEDNTSVADNISRQILNGELTGGAFRNGRRACLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVFWQDIRWKNKFWGKSMEILPVGTLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSVCICKLTFVKVNYWNSNMNEVQGVVIDQEGKAVYRLFGKWHEGLYCGVAPSAKCIWRPGSMPTNYELYYGFTRFAIELNELDPVLKDLLPPTDARFRPDQRFLEEGNLEAAASEKQRVEELQRSRRRYMEENNLEHIPKFFKKVIDANQREAWVSNDTYWELRKDPGFSKVDSPVLW | |
| oxysterol-binding protein-related protein 6 isoform e | |
|---|---|
| Refseq ID | NP_001188411 |
| Protein GI | 319996739 |
| UniProt ID | Q9BZF3 |
| mRNA ID | NM_001201482 |
| Length | 898 |
| RefSeq Status | REVIEWED |
| MSSDEKGISPAHKTSTPTHRSASSSTSSQRDSRQSIHILERTASSSTEPSVSRQLLEPEPVPLSKEADSWEIIEGLKIGQTNVQKPDKHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKSQDWFDAWVSKLRHHRLYRQNEIVRSPRDASFHIFPSTSTAESSPAANVSVMDGKMQPNSFPWQSPLPCSNSLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQNLEILQRTQSAPNFTDMQANCVDISKKDKRVTRRWRTKSVSKDTKIQLQVPFSATMSPVRLHSSNPNLCADIEFQTPPSHLTDPLESSTDYTKLQEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDHSKGHSTQMARLRQSLSQAGEQIHVSLPLSQQVANESRLSMSESVSEFFDAQEVLLSASSSENEASDDESYISDVSDNISEDNTSVADNISRQILNGELTGGAFRNGRRACLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVFWQDIRWKNKFWGKSMEILPVGTLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSVCICKLTFVKVNYWNSNMNEVQGVVIDQEGKAVYRLFGKWHEGLYCGVAPSAKCIWRPGSMPTNYELYYGFTRFAIELNELDPVLKDLLPPTDARFRPDQRFLEEGNLEAAASEKQRVEELQRSRRRYMEENNLEHIPKFFKKVIDANQREAWVSNDTYWELRKDPGFSKVDSPVLW | |
Gene Information
Entrez Gene ID
Gene Name
oxysterol binding protein-like 6
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | IDA:BHF-UCL | C | cytosol |
| GO:0031965 | IDA:BHF-UCL | C | nuclear membrane |
| GO:0097038 | IDA:BHF-UCL | C | perinuclear endoplasmic reticulum |
| GO:0005886 | IDA:BHF-UCL | C | plasma membrane |
| GO:0008289 | IEA:UniProtKB-KW | F | lipid binding |
| GO:0006869 | IEA:UniProtKB-KW | P | lipid transport |
Domain Information
UniProt Annotations
Entry Information
Gene Name
oxysterol binding protein-like 6
Protein Entry
OSBL6_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q9BZF3-1; Sequence=Displayed; Name=2; IsoId=Q9BZF3-2; Sequence=VSP_010013; Name=3; IsoId=Q9BZF3-3; Sequence=VSP_036559, VSP_036561; Name=4; IsoId=Q9BZF3-4; Sequence=VSP_036560; Name=5; IsoId=Q9BZF3-5; Sequence=VSP_036561; Name=6; IsoId=Q9BZF3-6; Sequence=VSP_036560, VSP_010013, VSP_054430, VSP_054431; Note=No experimental confirmation available.; |
| Interaction | Q9Q2G4:ORF (xeno); NbExp=3; IntAct=EBI-2372709, EBI-6248094; |
| Sequence Caution | Sequence=BAB55223.1; Type=Erroneous initiation; Evidence= ; Sequence=BAD92135.1; Type=Erroneous initiation; Evidence= ; |
| Similarity | Belongs to the OSBP family. |
| Similarity | Contains 1 PH domain. {ECO |
| Tissue Specificity | Widely expressed. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006738 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 14210532 | RefSeq | NP_115912 | 934 | oxysterol-binding protein-related protein 6 isoform a |
| 22035612 | RefSeq | NP_665682 | 938 | oxysterol-binding protein-related protein 6 isoform b |
| 319996735 | RefSeq | NP_001188409 | 959 | oxysterol-binding protein-related protein 6 isoform c |
| 319996735 | RefSeq | NP_001188410 | 959 | oxysterol-binding protein-related protein 6 isoform d |
| 319996739 | RefSeq | NP_001188411 | 898 | oxysterol-binding protein-related protein 6 isoform e |
Identical Sequences to LMP006738 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:319996735 | DBBJ | BAG10622.1 | 959 | oxysterol-binding protein-related protein 6, partial [synthetic construct] |
| GI:319996735 | DBBJ | BAG10622.1 | 959 | oxysterol-binding protein-related protein 6, partial [synthetic construct] |
| GI:14210532 | GenBank | AAG53409.1 | 934 | OSBP-related protein 6 [Homo sapiens] |
| GI:14210532 | GenBank | AAL40661.1 | 934 | oxysterol-binding protein-like protein OSBPL6 [Homo sapiens] |
| GI:319996739 | GenBank | AAP97711.1 | 898 | OSBP-related protein 6 isoform [Homo sapiens] |
| GI:14210532 | GenBank | EAX11040.1 | 934 | oxysterol binding protein-like 6, isoform CRA_b [Homo sapiens] |
| GI:14210532 | GenBank | EAX11041.1 | 934 | oxysterol binding protein-like 6, isoform CRA_b [Homo sapiens] |
| GI:319996735 | GenBank | EAX11042.1 | 959 | oxysterol binding protein-like 6, isoform CRA_c [Homo sapiens] |
| GI:319996735 | GenBank | EAX11042.1 | 959 | oxysterol binding protein-like 6, isoform CRA_c [Homo sapiens] |
| GI:319996735 | GenBank | EAX11043.1 | 959 | oxysterol binding protein-like 6, isoform CRA_c [Homo sapiens] |
| GI:319996735 | GenBank | EAX11043.1 | 959 | oxysterol binding protein-like 6, isoform CRA_c [Homo sapiens] |
| GI:14210532 | GenBank | AHD71025.1 | 934 | Sequence 4493 from patent US 8586006 |
| GI:22035612 | GenBank | AHD71026.1 | 938 | Sequence 4494 from patent US 8586006 |
| GI:14210532 | SwissProt | Q9BZF3.1 | 934 | RecName: Full=Oxysterol-binding protein-related protein 6; Short=ORP-6; Short=OSBP-related protein 6 [Homo sapiens] |
Related Sequences to LMP006738 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22035612 | DBBJ | BAC04248.1 | 938 | unnamed protein product [Homo sapiens] |
| GI:319996735 | DBBJ | BAD92135.1 | 966 | oxysterol-binding protein-like protein 6 isoform a variant, partial [Homo sapiens] |
| GI:22035612 | DBBJ | BAD92135.1 | 966 | oxysterol-binding protein-like protein 6 isoform a variant, partial [Homo sapiens] |
| GI:319996735 | DBBJ | BAD92135.1 | 966 | oxysterol-binding protein-like protein 6 isoform a variant, partial [Homo sapiens] |
| GI:22035612 | GenBank | ABA68213.1 | 938 | Sequence 3855 from patent US 6943241 |
| GI:319996739 | GenBank | EAX11039.1 | 923 | oxysterol binding protein-like 6, isoform CRA_a [Homo sapiens] |
| GI:319996735 | RefSeq | XP_003253823.1 | 959 | PREDICTED: oxysterol-binding protein-related protein 6 isoform 2 [Nomascus leucogenys] |
| GI:319996735 | RefSeq | XP_003253823.1 | 959 | PREDICTED: oxysterol-binding protein-related protein 6 isoform 2 [Nomascus leucogenys] |
| GI:319996739 | RefSeq | XP_003253825.1 | 898 | PREDICTED: oxysterol-binding protein-related protein 6 isoform 4 [Nomascus leucogenys] |
| GI:22035612 | RefSeq | XP_003253826.1 | 938 | PREDICTED: oxysterol-binding protein-related protein 6 isoform 5 [Nomascus leucogenys] |
| GI:14210532 | RefSeq | XP_003776078.1 | 934 | PREDICTED: oxysterol-binding protein-related protein 6 isoform X1 [Pongo abelii] |
| GI:319996735 | RefSeq | XP_003815563.1 | 959 | PREDICTED: oxysterol-binding protein-related protein 6 isoform X1 [Pan paniscus] |
| GI:319996735 | RefSeq | XP_003815563.1 | 959 | PREDICTED: oxysterol-binding protein-related protein 6 isoform X1 [Pan paniscus] |
| GI:319996739 | RefSeq | XP_003815565.1 | 898 | PREDICTED: oxysterol-binding protein-related protein 6 isoform X5 [Pan paniscus] |
| GI:319996735 | RefSeq | XP_003921872.1 | 959 | PREDICTED: oxysterol-binding protein-related protein 6 isoform X2 [Saimiri boliviensis boliviensis] |
| GI:319996735 | RefSeq | XP_003921872.1 | 959 | PREDICTED: oxysterol-binding protein-related protein 6 isoform X2 [Saimiri boliviensis boliviensis] |
| GI:14210532 | RefSeq | XP_004032908.1 | 934 | PREDICTED: oxysterol-binding protein-related protein 6 isoform 1 [Gorilla gorilla gorilla] |
| GI:319996735 | RefSeq | XP_004032909.1 | 959 | PREDICTED: oxysterol-binding protein-related protein 6 isoform 2 [Gorilla gorilla gorilla] |
| GI:319996735 | RefSeq | XP_004032909.1 | 959 | PREDICTED: oxysterol-binding protein-related protein 6 isoform 2 [Gorilla gorilla gorilla] |
| GI:319996739 | RefSeq | XP_004032911.1 | 898 | PREDICTED: oxysterol-binding protein-related protein 6 isoform 4 [Gorilla gorilla gorilla] |
| GI:22035612 | RefSeq | XP_004032912.1 | 938 | PREDICTED: oxysterol-binding protein-related protein 6 isoform 5 [Gorilla gorilla gorilla] |
| GI:22035612 | RefSeq | XP_005573647.1 | 951 | PREDICTED: oxysterol-binding protein-related protein 6 isoform X6 [Macaca fascicularis] |
| GI:319996739 | RefSeq | XP_005573655.1 | 898 | PREDICTED: oxysterol-binding protein-related protein 6 isoform X14 [Macaca fascicularis] |
| GI:319996739 | RefSeq | XP_006712295.1 | 923 | PREDICTED: oxysterol-binding protein-related protein 6 isoform X3 [Homo sapiens] |
| GI:319996735 | RefSeq | XP_008966742.1 | 959 | PREDICTED: oxysterol-binding protein-related protein 6 isoform X1 [Pan paniscus] |
| GI:319996735 | RefSeq | XP_008966742.1 | 959 | PREDICTED: oxysterol-binding protein-related protein 6 isoform X1 [Pan paniscus] |
| GI:14210532 | RefSeq | XP_008966743.1 | 934 | PREDICTED: oxysterol-binding protein-related protein 6 isoform X2 [Pan paniscus] |
| GI:14210532 | RefSeq | XP_009236146.1 | 934 | PREDICTED: oxysterol-binding protein-related protein 6 isoform X1 [Pongo abelii] |
| GI:14210532 | RefSeq | XP_009236147.1 | 934 | PREDICTED: oxysterol-binding protein-related protein 6 isoform X1 [Pongo abelii] |
| GI:14210532 | RefSeq | XP_009236148.1 | 934 | PREDICTED: oxysterol-binding protein-related protein 6 isoform X1 [Pongo abelii] |