Gene/Proteome Database (LMPD)

LMPD ID
LMP006740
Gene ID
54872
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class G
Gene Symbol
PIGG
Synonyms
GPI7; LAS21; PRO4405; RLGS1930
Chromosome
4
Map Location
4p16.3
EC Number
2.-.-.-

Proteins

GPI ethanolamine phosphate transferase 2 isoform 1
Refseq ID NP_001120650
Protein GI 187608446
UniProt ID Q5H8A4
mRNA ID NM_001127178
Length 983
RefSeq Status VALIDATED
MRLGSGTFATCCVAIEVLGIAVFLRGFFPAPVRSSARAEHGAEPPAPEPSAGASSNWTTLPPPLFSKVVIVLIDALRDDFVFGSKGVKFMPYTTYLVEKGASHSFVAEAKPPTVTMPRIKALMTGSLPGFVDVIRNLNSPALLEDSVIRQAKAAGKRIVFYGDETWVKLFPKHFVEYDGTTSFFVSDYTEVDNNVTRHLDKVLKRGDWDILILHYLGLDHIGHISGPNSPLIGQKLSEMDSVLMKIHTSLQSKERETPLPNLLVLCGDHGMSETGSHGASSTEEVNTPLILISSAFERKPGDIRHPKHVQQTDVAATLAIALGLPIPKDSVGSLLFPVVEGRPMREQLRFLHLNTVQLSKLLQENVPSYEKDPGFEQFKMSERLHGNWIRLYLEEKHSEVLFNLGSKVLRQYLDALKTLSLSLSAQVAQYDIYSMMVGTVVVLEVLTLLLLSVPQALRRKAELEVPLSSPGFSLLFYLVILVLSAVHVIVCTSAESSCYFCGLSWLAAGGVMVLASALLCVIVSVLTNVLVGGNTPRKNPMHPSSRWSELDLLILLGTAGHVLSLGASSFVEEEHQTWYFLVNTLCLALSQETYRNYFLGDDGEPPCGLCVEQGHDGATAAWQDGPGCDVLERDKGHGSPSTSEVLRGREKWMVLASPWLILACCRLLRSLNQTGVQWAHRPDLGHWLTSSDHKAELSVLAALSLLVVFVLVQRGCSPVSKAALALGLLGVYCYRAAIGSVRFPWRPDSKDISKGIIEARFVYVFVLGILFTGTKDLLKSQVIAADFKLKTVGLWEIYSGLVLLAALLFRPHNLPVLAFSLLIQTLMTKFIWKPLRHDAAEITVMHYWFGQAFFYFQGNSNNIATVDISAGFVGLDTYVEIPAVLLTAFGTYAGPVLWASHLVHFLSSETRSGSALSHACFCYALICSIPVFTYIVLVTSLRYHLFIWSVFSPKLLYEGMHLLITAAVCVFFTAMDQTRLTQS
GPI ethanolamine phosphate transferase 2 isoform 2
Refseq ID NP_060203
Protein GI 573459701
UniProt ID Q5H8A4
mRNA ID NM_017733
Length 299
RefSeq Status VALIDATED
MPYTTYLVEKGASHSFVAEAKPPTVTMPRIKALMTGSLPGFVDVIRNLNSPALLEDSVIRQAKAAGKRIVFYGDETWVKLFPKHFVEYDGTTSFFVSDYTEVDNNVTRHLDKVLKRGDWDILILHYLGLDHIGHISGPNSPLIGQKLSEMDSVLMKIHTSLQSKERETPLPNLLVLCGDHGMSETGSHGASSTEEVNTPLILISSAFERKPGDIRHPKHVQQTDVAATLAIALGLPIPKDSVGSLLFPVVEGRPMREQLRFLHLNTVQLSKLLQENVPSYEKGSHPAPAQRPTGTAQKG
GPI ethanolamine phosphate transferase 2 isoform 3
Refseq ID NP_001275980
Protein GI 573459752
UniProt ID Q8NCI4
mRNA ID NM_001289051
Length 894
RefSeq Status VALIDATED
MPYTTYLVEKGASHSFVAEAKPPTVTMPRIKALMTGSLPGFVDVIRNLNSPALLEDSVIRQAKAAGKRIVFYGDETWVKLFPKHFVEYDGTTSFFVSDYTEVDNNVTRHLDKVLKRGDWDILILHYLGLDHIGHISGPNSPLIGQKLSEMDSVLMKIHTSLQSKERETPLPNLLVLCGDHGMSETGSHGASSTEEVNTPLILISSAFERKPGDIRHPKHVQQTDVAATLAIALGLPIPKDSVGSLLFPVVEGRPMREQLRFLHLNTVQLSKLLQENVPSYEKDPGFEQFKMSERLHGNWIRLYLEEKHSEVLFNLGSKVLRQYLDALKTLSLSLSAQVAQYDIYSMMVGTVVVLEVLTLLLLSVPQALRRKAELEVPLSSPGFSLLFYLVILVLSAVHVIVCTSAESSCYFCGLSWLAAGGVMVLASALLCVIVSVLTNVLVGGNTPRKNPMHPSSRWSELDLLILLGTAGHVLSLGASSFVEEEHQTWYFLVNTLCLALSQETYRNYFLGDDGEPPCGLCVEQGHDGATAAWQDGPGCDVLERDKGHGSPSTSEVLRGREKWMVLASPWLILACCRLLRSLNQTGVQWAHRPDLGHWLTSSDHKAELSVLAALSLLVVFVLVQRGCSPVSKAALALGLLGVYCYRAAIGSVRFPWRPDSKDISKGIIEARFVYVFVLGILFTGTKDLLKSQVIAADFKLKTVGLWEIYSGLVLLAALLFRPHNLPVLAFSLLIQTLMTKFIWKPLRHDAAEITVMHYWFGQAFFYFQGNSNNIATVDISAGFVGLDTYVEIPAVLLTAFGTYAGPVLWASHLVHFLSSETRSGSALSHACFCYALICSIPVFTYIVLVTSLRYHLFIWSVFSPKLLYEGMHLLITAAVCVFFTAMDQTRLTQS
GPI ethanolamine phosphate transferase 2 isoform 4
Refseq ID NP_001275981
Protein GI 573459752
UniProt ID Q5H8A4
mRNA ID NM_001289052
Length 894
RefSeq Status VALIDATED
MPYTTYLVEKGASHSFVAEAKPPTVTMPRIKALMTGSLPGFVDVIRNLNSPALLEDSVIRQAKAAGKRIVFYGDETWVKLFPKHFVEYDGTTSFFVSDYTEVDNNVTRHLDKVLKRGDWDILILHYLGLDHIGHISGPNSPLIGQKLSEMDSVLMKIHTSLQSKERETPLPNLLVLCGDHGMSETGSHGASSTEEVNTPLILISSAFERKPGDIRHPKHVQQTDVAATLAIALGLPIPKDSVGSLLFPVVEGRPMREQLRFLHLNTVQLSKLLQENVPSYEKDPGFEQFKMSERLHGNWIRLYLEEKHSEVLFNLGSKVLRQYLDALKTLSLSLSAQVAQYDIYSMMVGTVVVLEVLTLLLLSVPQALRRKAELEVPLSSPGFSLLFYLVILVLSAVHVIVCTSAESSCYFCGLSWLAAGGVMVLASALLCVIVSVLTNVLVGGNTPRKNPMHPSSRWSELDLLILLGTAGHVLSLGASSFVEEEHQTWYFLVNTLCLALSQETYRNYFLGDDGEPPCGLCVEQGHDGATAAWQDGPGCDVLERDKGHGSPSTSEVLRGREKWMVLASPWLILACCRLLRSLNQTGVQWAHRPDLGHWLTSSDHKAELSVLAALSLLVVFVLVQRGCSPVSKAALALGLLGVYCYRAAIGSVRFPWRPDSKDISKGIIEARFVYVFVLGILFTGTKDLLKSQVIAADFKLKTVGLWEIYSGLVLLAALLFRPHNLPVLAFSLLIQTLMTKFIWKPLRHDAAEITVMHYWFGQAFFYFQGNSNNIATVDISAGFVGLDTYVEIPAVLLTAFGTYAGPVLWASHLVHFLSSETRSGSALSHACFCYALICSIPVFTYIVLVTSLRYHLFIWSVFSPKLLYEGMHLLITAAVCVFFTAMDQTRLTQS
GPI ethanolamine phosphate transferase 2 isoform 5
Refseq ID NP_001275982
Protein GI 573459752
UniProt ID D6RFE8
mRNA ID NM_001289053
Length 894
RefSeq Status VALIDATED
MPYTTYLVEKGASHSFVAEAKPPTVTMPRIKALMTGSLPGFVDVIRNLNSPALLEDSVIRQAKAAGKRIVFYGDETWVKLFPKHFVEYDGTTSFFVSDYTEVDNNVTRHLDKVLKRGDWDILILHYLGLDHIGHISGPNSPLIGQKLSEMDSVLMKIHTSLQSKERETPLPNLLVLCGDHGMSETGSHGASSTEEVNTPLILISSAFERKPGDIRHPKHVQQTDVAATLAIALGLPIPKDSVGSLLFPVVEGRPMREQLRFLHLNTVQLSKLLQENVPSYEKDPGFEQFKMSERLHGNWIRLYLEEKHSEVLFNLGSKVLRQYLDALKTLSLSLSAQVAQYDIYSMMVGTVVVLEVLTLLLLSVPQALRRKAELEVPLSSPGFSLLFYLVILVLSAVHVIVCTSAESSCYFCGLSWLAAGGVMVLASALLCVIVSVLTNVLVGGNTPRKNPMHPSSRWSELDLLILLGTAGHVLSLGASSFVEEEHQTWYFLVNTLCLALSQETYRNYFLGDDGEPPCGLCVEQGHDGATAAWQDGPGCDVLERDKGHGSPSTSEVLRGREKWMVLASPWLILACCRLLRSLNQTGVQWAHRPDLGHWLTSSDHKAELSVLAALSLLVVFVLVQRGCSPVSKAALALGLLGVYCYRAAIGSVRFPWRPDSKDISKGIIEARFVYVFVLGILFTGTKDLLKSQVIAADFKLKTVGLWEIYSGLVLLAALLFRPHNLPVLAFSLLIQTLMTKFIWKPLRHDAAEITVMHYWFGQAFFYFQGNSNNIATVDISAGFVGLDTYVEIPAVLLTAFGTYAGPVLWASHLVHFLSSETRSGSALSHACFCYALICSIPVFTYIVLVTSLRYHLFIWSVFSPKLLYEGMHLLITAAVCVFFTAMDQTRLTQS
GPI ethanolamine phosphate transferase 2 isoform 6
Refseq ID NP_001275984
Protein GI 573459748
UniProt ID Q5H8A4
mRNA ID NM_001289055
Length 341
RefSeq Status VALIDATED
MTGSLPGFVDVIRNLNSPALLEDSVIRQAKAAGKRIVFYGDETWVKLFPKHFVEYDGTTSFFVSDYTEVDNNVTRHLDKVLKRGDWDILILHYLGLDHIGHISGPNSPLIGQKLSEMDSVLMKIHTSLQSKERETPLPNLLVLCGDHGMSETGSHGASSTEEVNTPLILISSAFERKPGDIRHPKHVQQTDVAATLAIALGLPIPKDSVGSLLFPVVEGRPMREQLRFLHLNTVQLSKLLQENVPSYEKDPGFEQFKMSERLHGNWIRLYLEEKHSEVLFNLGSKVLRQYLDALKTLSLSLSAQVAQFSPCSCSASHRHCAERLSWKSHCHLLGFLCSFIW
GPI ethanolamine phosphate transferase 2 isoform 7
Refseq ID NP_001275986
Protein GI 573459701
UniProt ID Q5H8A4
mRNA ID NM_001289057
Length 299
RefSeq Status VALIDATED
MPYTTYLVEKGASHSFVAEAKPPTVTMPRIKALMTGSLPGFVDVIRNLNSPALLEDSVIRQAKAAGKRIVFYGDETWVKLFPKHFVEYDGTTSFFVSDYTEVDNNVTRHLDKVLKRGDWDILILHYLGLDHIGHISGPNSPLIGQKLSEMDSVLMKIHTSLQSKERETPLPNLLVLCGDHGMSETGSHGASSTEEVNTPLILISSAFERKPGDIRHPKHVQQTDVAATLAIALGLPIPKDSVGSLLFPVVEGRPMREQLRFLHLNTVQLSKLLQENVPSYEKGSHPAPAQRPTGTAQKG

Gene Information

Entrez Gene ID
54872
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class G
Gene Symbol
PIGG
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:MGI C endoplasmic reticulum
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0051267 IDA:MGI F CP2 mannose-ethanolamine phosphotransferase activity
GO:0016780 TAS:Reactome F phosphotransferase activity, for other substituted phosphate groups
GO:0044267 TAS:Reactome P cellular protein metabolic process
GO:0006501 TAS:Reactome P C-terminal protein lipidation
GO:0006506 IDA:MGI P GPI anchor biosynthetic process
GO:0043687 TAS:Reactome P post-translational protein modification
GO:0016254 TAS:Reactome P preassembly of GPI anchor in ER membrane

KEGG Pathway Links

KEGG Pathway ID Description
hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
ko00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_1853 Post-translational modification: synthesis of GPI-anchored proteins
REACT_952 Synthesis of glycosylphosphatidylinositol (GPI)

Domain Information

InterPro Annotations

Accession Description
IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
IPR017850 Alkaline-phosphatase-like, core domain
IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol glycan anchor biosynthesis, class G
Protein Entry
PIGG_HUMAN
UniProt ID
Q8NCI4
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q5H8A4-1; Sequence=Displayed; Name=2; IsoId=Q5H8A4-2; Sequence=VSP_019832; Note=No experimental confirmation available.; Name=3; IsoId=Q5H8A4-3; Sequence=VSP_019828; Note=No experimental confirmation available.; Name=4; IsoId=Q5H8A4-4; Sequence=VSP_019831, VSP_019833; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=5; IsoId=Q5H8A4-5; Sequence=VSP_019827, VSP_019829, VSP_019830; Note=No experimental confirmation available.; Name=6; IsoId=Q5H8A4-6; Sequence=VSP_054387, VSP_054388, VSP_019833; Note=No experimental confirmation available.;
Function Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.
Pathway Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Sequence Caution Sequence=AAQ88902.1; Type=Erroneous termination; Positions=311; Note=Translated as Gln.; Evidence= ; Sequence=BAA91046.1; Type=Erroneous initiation; Evidence= ; Sequence=BAB55130.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Subunit Forms a complex with PIGF. PIGF is required to stabilize it. Competes with PIGO for the binding of PIGF.

Identical and Related Proteins

Unique RefSeq proteins for LMP006740 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
187608446 RefSeq NP_001120650 983 GPI ethanolamine phosphate transferase 2 isoform 1
573459701 RefSeq NP_060203 299 GPI ethanolamine phosphate transferase 2 isoform 2
573459752 RefSeq NP_001275980 894 GPI ethanolamine phosphate transferase 2 isoform 3
573459752 RefSeq NP_001275981 894 GPI ethanolamine phosphate transferase 2 isoform 4
573459752 RefSeq NP_001275982 894 GPI ethanolamine phosphate transferase 2 isoform 5
573459748 RefSeq NP_001275984 341 GPI ethanolamine phosphate transferase 2 isoform 6
573459701 RefSeq NP_001275986 299 GPI ethanolamine phosphate transferase 2 isoform 7

Identical Sequences to LMP006740 proteins

Reference Database Accession Length Protein Name
GI:573459701 DBBJ BAC04984.1 299 unnamed protein product [Homo sapiens]
GI:573459701 DBBJ BAC04984.1 299 unnamed protein product [Homo sapiens]
GI:187608446 DBBJ BAD89023.1 983 GPI7 [Homo sapiens]
GI:573459748 DBBJ BAG59139.1 341 unnamed protein product [Homo sapiens]
GI:573459701 GenBank ABP29197.1 299 Sequence 4212 from patent US 7193069
GI:573459701 GenBank ABP29197.1 299 Sequence 4212 from patent US 7193069
GI:573459752 RefSeq XP_005272341.1 894 PREDICTED: GPI ethanolamine phosphate transferase 2 isoform X2 [Homo sapiens]
GI:573459752 RefSeq XP_005272341.1 894 PREDICTED: GPI ethanolamine phosphate transferase 2 isoform X2 [Homo sapiens]
GI:573459752 RefSeq XP_005272341.1 894 PREDICTED: GPI ethanolamine phosphate transferase 2 isoform X2 [Homo sapiens]
GI:573459748 RefSeq XP_008961982.1 341 PREDICTED: GPI ethanolamine phosphate transferase 2 isoform X9 [Pan paniscus]
GI:187608446 SwissProt Q5H8A4.1 983 RecName: Full=GPI ethanolamine phosphate transferase 2; AltName: Full=GPI7 homolog; Short=hGPI7; AltName: Full=Phosphatidylinositol-glycan biosynthesis class G protein; Short=PIG-G [Homo sapiens]

Related Sequences to LMP006740 proteins

Reference Database Accession Length Protein Name
GI:573459752 DBBJ BAC11157.1 894 unnamed protein product [Homo sapiens]
GI:573459701 DBBJ BAC11157.1 894 unnamed protein product [Homo sapiens]
GI:573459701 DBBJ BAC11157.1 894 unnamed protein product [Homo sapiens]
GI:573459748 DBBJ BAC11157.1 894 unnamed protein product [Homo sapiens]
GI:573459752 DBBJ BAC11157.1 894 unnamed protein product [Homo sapiens]
GI:573459752 DBBJ BAC11157.1 894 unnamed protein product [Homo sapiens]
GI:573459701 DBBJ BAC11227.1 975 unnamed protein product [Homo sapiens]
GI:573459701 DBBJ BAC11227.1 975 unnamed protein product [Homo sapiens]
GI:573459752 DBBJ BAD89023.1 983 GPI7 [Homo sapiens]
GI:573459752 DBBJ BAD89023.1 983 GPI7 [Homo sapiens]
GI:573459752 DBBJ BAD89023.1 983 GPI7 [Homo sapiens]
GI:573459701 EMBL CAF85981.1 975 unnamed protein product [Homo sapiens]
GI:573459748 EMBL CAF85981.1 975 unnamed protein product [Homo sapiens]
GI:573459701 EMBL CAF85981.1 975 unnamed protein product [Homo sapiens]
GI:573459748 EMBL CAF86776.1 894 unnamed protein product [Homo sapiens]
GI:573459752 EMBL CAF86776.1 894 unnamed protein product [Homo sapiens]
GI:573459752 EMBL CAF86776.1 894 unnamed protein product [Homo sapiens]
GI:573459701 EMBL CAF86776.1 894 unnamed protein product [Homo sapiens]
GI:573459752 EMBL CAF86776.1 894 unnamed protein product [Homo sapiens]
GI:573459701 EMBL CAF86776.1 894 unnamed protein product [Homo sapiens]
GI:573459752 GenBank EAW82665.1 983 phosphatidylinositol glycan, class G, isoform CRA_c [Homo sapiens]
GI:573459752 GenBank EAW82665.1 983 phosphatidylinositol glycan, class G, isoform CRA_c [Homo sapiens]
GI:573459752 GenBank EAW82665.1 983 phosphatidylinositol glycan, class G, isoform CRA_c [Homo sapiens]
GI:187608446 GenBank EAW82665.1 983 phosphatidylinositol glycan, class G, isoform CRA_c [Homo sapiens]
GI:187608446 GenBank JAA06172.1 983 phosphatidylinositol glycan anchor biosynthesis, class G [Pan troglodytes]
GI:187608446 GenBank JAA19114.1 983 phosphatidylinositol glycan anchor biosynthesis, class G [Pan troglodytes]
GI:187608446 GenBank JAA24493.1 983 phosphatidylinositol glycan anchor biosynthesis, class G [Pan troglodytes]
GI:187608446 GenBank JAA43042.1 983 phosphatidylinositol glycan anchor biosynthesis, class G [Pan troglodytes]
GI:187608446 RefSeq XP_001138024.1 983 PREDICTED: GPI ethanolamine phosphate transferase 2 isoform X1 [Pan troglodytes]
GI:573459701 RefSeq NP_001120650.1 983 GPI ethanolamine phosphate transferase 2 isoform 1 [Homo sapiens]
GI:573459752 RefSeq NP_001120650.1 983 GPI ethanolamine phosphate transferase 2 isoform 1 [Homo sapiens]
GI:573459752 RefSeq NP_001120650.1 983 GPI ethanolamine phosphate transferase 2 isoform 1 [Homo sapiens]
GI:573459752 RefSeq NP_001120650.1 983 GPI ethanolamine phosphate transferase 2 isoform 1 [Homo sapiens]
GI:573459701 RefSeq NP_001120650.1 983 GPI ethanolamine phosphate transferase 2 isoform 1 [Homo sapiens]
GI:573459748 RefSeq XP_008016409.1 463 PREDICTED: GPI ethanolamine phosphate transferase 2 isoform X10 [Chlorocebus sabaeus]
GI:573459748 RefSeq XP_008567679.1 495 PREDICTED: GPI ethanolamine phosphate transferase 2 [Galeopterus variegatus]
GI:573459701 RefSeq XP_009204487.1 299 PREDICTED: GPI ethanolamine phosphate transferase 2 isoform X5 [Papio anubis]
GI:573459701 RefSeq XP_009204487.1 299 PREDICTED: GPI ethanolamine phosphate transferase 2 isoform X5 [Papio anubis]
GI:573459748 RefSeq XP_010373610.1 341 PREDICTED: GPI ethanolamine phosphate transferase 2 isoform X2 [Rhinopithecus roxellana]
GI:573459752 SwissProt Q5H8A4.1 983 RecName: Full=GPI ethanolamine phosphate transferase 2; AltName: Full=GPI7 homolog; Short=hGPI7; AltName: Full=Phosphatidylinositol-glycan biosynthesis class G protein; Short=PIG-G [Homo sapiens]
GI:573459752 SwissProt Q5H8A4.1 983 RecName: Full=GPI ethanolamine phosphate transferase 2; AltName: Full=GPI7 homolog; Short=hGPI7; AltName: Full=Phosphatidylinositol-glycan biosynthesis class G protein; Short=PIG-G [Homo sapiens]
GI:573459752 SwissProt Q5H8A4.1 983 RecName: Full=GPI ethanolamine phosphate transferase 2; AltName: Full=GPI7 homolog; Short=hGPI7; AltName: Full=Phosphatidylinositol-glycan biosynthesis class G protein; Short=PIG-G [Homo sapiens]