Gene/Proteome Database (LMPD)
LMPD ID
LMP006741
Gene ID
Species
Homo sapiens (Human)
Gene Name
oxysterol binding protein-like 9
Gene Symbol
Synonyms
ORP-9; ORP9
Alternate Names
oxysterol-binding protein-related protein 9; OSBP-related protein 9
Chromosome
1
Map Location
1p32.3
Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member functions as a cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified on chromosomes 3, 11 and 12. [provided by RefSeq, Jul 2010]
Orthologs
Proteins
| oxysterol-binding protein-related protein 9 isoform a | |
|---|---|
| Refseq ID | NP_683702 |
| Protein GI | 22547165 |
| UniProt ID | Q96SU4 |
| mRNA ID | NM_148904 |
| Length | 558 |
| RefSeq Status | REVIEWED |
| MVESIKHCIVLLQIAKSTINPVDAIYQPSPLEPVISTMPSQTVLPPEPVQLCKSEQRPSSLPVGPVLATLGHHQTPTPNSTGSGHSPPSSSLTSPSHVNLSPNTVPEFSYSSSEDEFYDADEFHQSGSSPKRLIDSSGSASVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRDDDAEAGSVEEHKSVIMHLLSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGYGRSILTVPWVELGGECNINCSKTGYSANIIFHTKPFYGGKKHRITAEIFSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKKVRKLEDQNEYESRSLWKDVTFNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDGECWVYDEPLLKRLGAAKH | |
| oxysterol-binding protein-related protein 9 isoform a | |
|---|---|
| Refseq ID | NP_683703 |
| Protein GI | 22547167 |
| UniProt ID | Q96SU4 |
| mRNA ID | NM_148905 |
| Length | 558 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:22547165 (mRNA isoform) | |
| oxysterol-binding protein-related protein 9 isoform b | |
|---|---|
| Refseq ID | NP_683704 |
| Protein GI | 308153253 |
| UniProt ID | Q96SU4 |
| mRNA ID | NM_148906 |
| Length | 719 |
| RefSeq Status | REVIEWED |
| MASIMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTGAVIGIDDEDDSTFTITVDQKTFHFQARDADEREKWIHALEETILRHTLQLQGLDSGFVPSVQDFDKKLTEADAYLQILIEQLKLFDDKLQNCKEDEQRKKIETLKETTNSMVESIKHCIVLLQIAKDQSNAEKHADGMISTINPVDAIYQPSPLEPVISTMPSQTVLPPEPVQLCKSEQRPSSLPVGPVLATLGHHQTPTPNSTGSGHSPPSSSLTSPSHVNLSPNTVPEFSYSSSEDEFYDADEFHQSGSSPKRLIDSSGSASVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRDDDAEAGSVEEHKSVIMHLLSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGYGRSILTVPWVELGGECNINCSKTGYSANIIFHTKPFYGGKKHRITAEIFSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKKVRKLEDQNEYESRSLWKDVTFNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDGECWVYDEPLLKRLGAAKH | |
| oxysterol-binding protein-related protein 9 isoform c | |
|---|---|
| Refseq ID | NP_683705 |
| Protein GI | 22547171 |
| UniProt ID | Q96SU4 |
| mRNA ID | NM_148907 |
| Length | 626 |
| RefSeq Status | REVIEWED |
| MAFLLATCGGLDSGFVPSVQDFDKKLTEADAYLQILIEQLKLFDDKLQNCKEDEQRKKIETLKETTNSMVESIKHCIVLLQIAKSTINPVDAIYQPSPLEPVISTMPSQTVLPPEPVQLCKSEQRPSSLPVGPVLATLGHHQTPTPNSTGSGHSPPSSSLTSPSHVNLSPNTVPEFSYSSSEDEFYDADEFHQSGSSPKRLIDSSGSASVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRDDDAEAGSVEEHKSVIMHLLSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGYGRSILTVPWVELGGECNINCSKTGYSANIIFHTKPFYGGKKHRITAEIFSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKKVRKLEDQNEYESRSLWKDVTFNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDGECWVYDEPLLKRLGAAKH | |
| oxysterol-binding protein-related protein 9 isoform d | |
|---|---|
| Refseq ID | NP_683706 |
| Protein GI | 308153255 |
| UniProt ID | Q96SU4 |
| mRNA ID | NM_148908 |
| Length | 723 |
| RefSeq Status | REVIEWED |
| MASIMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDEDDSTFTITVDQKTFHFQARDADEREKWIHALEETILRHTLQLQGLDSGFVPSVQDFDKKLTEADAYLQILIEQLKLFDDKLQNCKEDEQRKKIETLKETTNSMVESIKHCIVLLQIAKSTINPVDAIYQPSPLEPVISTMPSQTVLPPEPVQLCKSEQRPSSLPVGPVLATLGHHQTPTPNSTGSGHSPPSSSLTSPSHVNLSPNTVPEFSYSSSEDEFYDADEFHQSGSSPKRLIDSSGSASVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRDDDAEAGSVEEHKSVIMHLLSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGYGRSILTVPWVELGGECNINCSKTGYSANIIFHTKPFYGGKKHRITAEIFSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKKVRKLEDQNEYESRSLWKDVTFNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDGECWVYDEPLLKRLGAAKH | |
| oxysterol-binding protein-related protein 9 isoform e | |
|---|---|
| Refseq ID | NP_078862 |
| Protein GI | 308153257 |
| UniProt ID | Q96SU4 |
| mRNA ID | NM_024586 |
| Length | 736 |
| RefSeq Status | REVIEWED |
| MASIMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDEDDSTFTITVDQKTFHFQARDADEREKWIHALEETILRHTLQLQGLDSGFVPSVQDFDKKLTEADAYLQILIEQLKLFDDKLQNCKEDEQRKKIETLKETTNSMVESIKHCIVLLQIAKDQSNAEKHADGMISTINPVDAIYQPSPLEPVISTMPSQTVLPPEPVQLCKSEQRPSSLPVGPVLATLGHHQTPTPNSTGSGHSPPSSSLTSPSHVNLSPNTVPEFSYSSSEDEFYDADEFHQSGSSPKRLIDSSGSASVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRDDDAEAGSVEEHKSVIMHLLSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGYGRSILTVPWVELGGECNINCSKTGYSANIIFHTKPFYGGKKHRITAEIFSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKKVRKLEDQNEYESRSLWKDVTFNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDGECWVYDEPLLKRLGAAKH | |
| oxysterol-binding protein-related protein 9 isoform f | |
|---|---|
| Refseq ID | NP_683707 |
| Protein GI | 308153260 |
| UniProt ID | Q96SU4 |
| mRNA ID | NM_148909 |
| Length | 746 |
| RefSeq Status | REVIEWED |
| MASIMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDEDDSTFTITVDQKTFHFQARDADEREKWIHALEETILRHTLQLQISTTLAFFQSSGISPVLEFSKIIGLDSGFVPSVQDFDKKLTEADAYLQILIEQLKLFDDKLQNCKEDEQRKKIETLKETTNSMVESIKHCIVLLQIAKSTINPVDAIYQPSPLEPVISTMPSQTVLPPEPVQLCKSEQRPSSLPVGPVLATLGHHQTPTPNSTGSGHSPPSSSLTSPSHVNLSPNTVPEFSYSSSEDEFYDADEFHQSGSSPKRLIDSSGSASVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRDDDAEAGSVEEHKSVIMHLLSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGYGRSILTVPWVELGGECNINCSKTGYSANIIFHTKPFYGGKKHRITAEIFSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKKVRKLEDQNEYESRSLWKDVTFNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDGECWVYDEPLLKRLGAAKH | |
Gene Information
Entrez Gene ID
Gene Name
oxysterol binding protein-like 9
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IDA:HPA | C | cytoplasm |
| GO:0005768 | IEA:UniProtKB-KW | C | endosome |
| GO:0005794 | IDA:HPA | C | Golgi apparatus |
| GO:0016020 | IEA:UniProtKB-KW | C | membrane |
| GO:0008289 | IEA:UniProtKB-KW | F | lipid binding |
| GO:0006869 | IEA:UniProtKB-KW | P | lipid transport |
Domain Information
UniProt Annotations
Entry Information
Gene Name
oxysterol binding protein-like 9
Protein Entry
OSBL9_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q96SU4-1; Sequence=Displayed; Name=2; IsoId=Q96SU4-2; Sequence=VSP_003782; Note=No experimental confirmation available.; Name=3; IsoId=Q96SU4-3; Sequence=VSP_036780, VSP_036781, VSP_003782; Name=4; IsoId=Q96SU4-4; Sequence=VSP_036779; Name=5; IsoId=Q96SU4-5; Sequence=VSP_036779, VSP_003782; Name=6; IsoId=Q96SU4-6; Sequence=VSP_043631, VSP_003782; Note=No experimental confirmation available.; Name=7; IsoId=Q96SU4-7; Sequence=VSP_043630; |
| Sequence Caution | Sequence=CAH71119.1; Type=Erroneous initiation; Evidence= ; |
| Similarity | Belongs to the OSBP family. |
| Similarity | Contains 1 PH domain. {ECO |
| Subcellular Location | Late endosome membrane . Golgi apparatus, trans-Golgi network membrane . Note=Localizes at the Golgi-late endosome interface. |
| Subunit | Heterodimer with OSBPL11. |
| Tissue Specificity | Widely expressed. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006741 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 22547165 | RefSeq | NP_683702 | 558 | oxysterol-binding protein-related protein 9 isoform a |
| 308153253 | RefSeq | NP_683704 | 719 | oxysterol-binding protein-related protein 9 isoform b |
| 22547171 | RefSeq | NP_683705 | 626 | oxysterol-binding protein-related protein 9 isoform c |
| 308153255 | RefSeq | NP_683706 | 723 | oxysterol-binding protein-related protein 9 isoform d |
| 308153257 | RefSeq | NP_078862 | 736 | oxysterol-binding protein-related protein 9 isoform e |
| 308153260 | RefSeq | NP_683707 | 746 | oxysterol-binding protein-related protein 9 isoform f |
Identical Sequences to LMP006741 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:308153255 | DBBJ | BAB55184.1 | 723 | unnamed protein product [Homo sapiens] |
| GI:308153260 | DBBJ | BAG51766.1 | 746 | unnamed protein product [Homo sapiens] |
| GI:308153255 | EMBL | CAD28989.1 | 723 | unnamed protein product [synthetic construct] |
| GI:308153255 | EMBL | CAE84540.1 | 723 | unnamed protein product [synthetic construct] |
| GI:308153255 | EMBL | CAE89348.1 | 723 | unnamed protein product [Homo sapiens] |
| GI:308153257 | GenBank | AAL40658.1 | 736 | oxysterol-binding protein-like protein OSBPL9 [Homo sapiens] |
| GI:308153253 | GenBank | AAO20108.1 | 719 | oxysterol-binding protein-like protein 9 [Homo sapiens] |
| GI:308153260 | GenBank | ABE15145.1 | 746 | Sequence 2678 from patent US 6979557 |
| GI:308153253 | GenBank | EAX06813.1 | 719 | oxysterol binding protein-like 9, isoform CRA_d [Homo sapiens] |
| GI:22547171 | GenBank | EAX06816.1 | 626 | oxysterol binding protein-like 9, isoform CRA_g [Homo sapiens] |
| GI:22547165 | GenBank | EAX06817.1 | 558 | oxysterol binding protein-like 9, isoform CRA_a [Homo sapiens] |
| GI:308153257 | GenBank | JAA21655.1 | 736 | oxysterol binding protein-like 9 [Pan troglodytes] |
| GI:308153257 | GenBank | JAA31999.1 | 736 | oxysterol binding protein-like 9 [Pan troglodytes] |
| GI:308153257 | GenBank | JAA36346.1 | 736 | oxysterol binding protein-like 9 [Pan troglodytes] |
| GI:308153255 | GenBank | JAA36347.1 | 723 | oxysterol binding protein-like 9 [Pan troglodytes] |
| GI:22547165 | RefSeq | XP_006710387.1 | 558 | PREDICTED: oxysterol-binding protein-related protein 9 isoform X7 [Homo sapiens] |
| GI:22547165 | RefSeq | XP_006710388.1 | 558 | PREDICTED: oxysterol-binding protein-related protein 9 isoform X8 [Homo sapiens] |
| GI:22547165 | RefSeq | XP_006710389.1 | 558 | PREDICTED: oxysterol-binding protein-related protein 9 isoform X9 [Homo sapiens] |
| GI:22547171 | RefSeq | XP_008953178.1 | 626 | PREDICTED: oxysterol-binding protein-related protein 9 isoform X4 [Pan paniscus] |
| GI:22547165 | RefSeq | XP_008953181.1 | 558 | PREDICTED: oxysterol-binding protein-related protein 9 isoform X6 [Pan paniscus] |
| GI:22547165 | RefSeq | XP_008953182.1 | 558 | PREDICTED: oxysterol-binding protein-related protein 9 isoform X6 [Pan paniscus] |
| GI:308153257 | SwissProt | Q96SU4.2 | 736 | RecName: Full=Oxysterol-binding protein-related protein 9; Short=ORP-9; Short=OSBP-related protein 9 [Homo sapiens] |
Related Sequences to LMP006741 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22547171 | DBBJ | BAB55312.1 | 626 | unnamed protein product [Homo sapiens] |
| GI:308153255 | DBBJ | BAG54621.1 | 741 | unnamed protein product [Homo sapiens] |
| GI:22547165 | DBBJ | BAG51766.1 | 746 | unnamed protein product [Homo sapiens] |
| GI:308153257 | DBBJ | BAK63172.1 | 736 | oxysterol-binding protein-related protein 9 [Pan troglodytes] |
| GI:22547171 | EMBL | CAE90909.1 | 626 | unnamed protein product [Homo sapiens] |
| GI:308153253 | GenBank | AAL40658.1 | 736 | oxysterol-binding protein-like protein OSBPL9 [Homo sapiens] |
| GI:22547165 | GenBank | ABE15145.1 | 746 | Sequence 2678 from patent US 6979557 |
| GI:308153260 | GenBank | EAX06811.1 | 764 | oxysterol binding protein-like 9, isoform CRA_b [Homo sapiens] |
| GI:308153257 | GenBank | EAX06812.1 | 754 | oxysterol binding protein-like 9, isoform CRA_c [Homo sapiens] |
| GI:308153255 | GenBank | EAX06814.1 | 741 | oxysterol binding protein-like 9, isoform CRA_e [Homo sapiens] |
| GI:22547165 | GenBank | EAX06816.1 | 626 | oxysterol binding protein-like 9, isoform CRA_g [Homo sapiens] |
| GI:308153260 | GenBank | EHH14779.1 | 747 | hypothetical protein EGK_00756, partial [Macaca mulatta] |
| GI:308153255 | GenBank | AFE71455.1 | 726 | oxysterol-binding protein-related protein 9 isoform d, partial [Macaca mulatta] |
| GI:308153255 | GenBank | AFH31021.1 | 723 | oxysterol-binding protein-related protein 9 isoform d [Macaca mulatta] |
| GI:308153255 | GenBank | AFI36182.1 | 723 | oxysterol-binding protein-related protein 9 isoform d [Macaca mulatta] |
| GI:308153257 | GenBank | JAA10924.1 | 754 | oxysterol binding protein-like 9 [Pan troglodytes] |
| GI:308153253 | GenBank | JAA31999.1 | 736 | oxysterol binding protein-like 9 [Pan troglodytes] |
| GI:308153253 | GenBank | JAA36346.1 | 736 | oxysterol binding protein-like 9 [Pan troglodytes] |
| GI:308153260 | GenBank | JAB44808.1 | 746 | oxysterol-binding protein-related protein 9 isoform f [Callithrix jacchus] |
| GI:22547165 | RefSeq | NP_683705.1 | 626 | oxysterol-binding protein-related protein 9 isoform c [Homo sapiens] |
| GI:22547165 | RefSeq | NP_683707.3 | 746 | oxysterol-binding protein-related protein 9 isoform f [Homo sapiens] |
| GI:308153253 | RefSeq | XP_003259033.1 | 719 | PREDICTED: oxysterol-binding protein-related protein 9 isoform 5 [Nomascus leucogenys] |
| GI:308153260 | RefSeq | XP_003259034.1 | 746 | PREDICTED: oxysterol-binding protein-related protein 9 isoform 6 [Nomascus leucogenys] |
| GI:22547171 | RefSeq | XP_003259035.1 | 626 | PREDICTED: oxysterol-binding protein-related protein 9 isoform 7 [Nomascus leucogenys] |
| GI:308153257 | RefSeq | NP_001267073.1 | 736 | oxysterol-binding protein-related protein 9 [Pan troglodytes] |
| GI:308153260 | RefSeq | XP_005543442.1 | 764 | PREDICTED: oxysterol-binding protein-related protein 9 isoform X1 [Macaca fascicularis] |
| GI:308153253 | RefSeq | XP_005543445.1 | 737 | PREDICTED: oxysterol-binding protein-related protein 9 isoform X4 [Macaca fascicularis] |
| GI:22547171 | RefSeq | XP_005543449.1 | 626 | PREDICTED: oxysterol-binding protein-related protein 9 isoform X8 [Macaca fascicularis] |
| GI:308153257 | RefSeq | XP_008953174.1 | 754 | PREDICTED: oxysterol-binding protein-related protein 9 isoform X1 [Pan paniscus] |
| GI:308153255 | RefSeq | XP_008953175.1 | 741 | PREDICTED: oxysterol-binding protein-related protein 9 isoform X2 [Pan paniscus] |
| GI:22547165 | RefSeq | XP_008953178.1 | 626 | PREDICTED: oxysterol-binding protein-related protein 9 isoform X4 [Pan paniscus] |
| GI:22547171 | RefSeq | XP_009248347.1 | 626 | PREDICTED: oxysterol-binding protein-related protein 9 isoform X6 [Pongo abelii] |
| GI:308153260 | RefSeq | XP_010368707.1 | 746 | PREDICTED: oxysterol-binding protein-related protein 9 isoform X2 [Rhinopithecus roxellana] |
| GI:308153257 | RefSeq | XP_010368710.1 | 736 | PREDICTED: oxysterol-binding protein-related protein 9 isoform X4 [Rhinopithecus roxellana] |
| GI:22547171 | RefSeq | XP_010368712.1 | 626 | PREDICTED: oxysterol-binding protein-related protein 9 isoform X6 [Rhinopithecus roxellana] |
| GI:308153253 | SwissProt | Q96SU4.2 | 736 | RecName: Full=Oxysterol-binding protein-related protein 9; Short=ORP-9; Short=OSBP-related protein 9 [Homo sapiens] |