Gene/Proteome Database (LMPD)

LMPD ID
LMP006744
Gene ID
23761
Species
Homo sapiens (Human)
Gene Name
phosphatidylserine decarboxylase
Gene Symbol
PISD
Synonyms
DJ858B16; PSD; PSDC; PSSC; dJ858B16.2
Alternate Names
phosphatidylserine decarboxylase proenzyme
Chromosome
22
Map Location
22q12.2
EC Number
4.1.1.65
Summary
Phosphatidylserine decarboxylases (PSDs; EC 4.1.1.65) catalyze the formation of phosphatidylethanolamine (PE) by decarboxylation of phosphatidylserine (PS). Type I PSDs, such as PISD, are targeted to the inner mitochondrial membrane by an N-terminal targeting sequence. PISD also contains a conserved LGST motif that functions as an autocatalytic cleavage site where the proenzyme is split into mature alpha and beta subunits (Schuiki and Daum, 2009 [PubMed 19165886]).[supplied by OMIM, Jul 2010]
Orthologs
View orthologs and multiple alignments for PISD

Proteins

phosphatidylserine decarboxylase proenzyme
Refseq ID NP_055153
Protein GI 13489112
UniProt ID Q9UG56
mRNA ID NM_014338
Length 375
RefSeq Status VALIDATED
MMCQSEARQGPELRAAKWLHFPQLALRRRLGQLSCMSRPALKLRSWPLTVLYYLLPFGALRPLSRVGWRPVSRVALYKSVPTRLLSRAWGRLNQVELPHWLRRPVYSLYIWTFGVNMKEAAVEDLHHYRNLSEFFRRKLKPQARPVCGLHSVISPSDGRILNFGQVKNCEVEQVKGVTYSLESFLGPRMCTEDLPFPPAASCDSFKNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIYFDRDLHTNSPRHSKGSYNDFSFVTHTNREGVPMRKGEHLGEFNLGSTIVLIFEAPKDFNFQLKTGQKIRFGEALGSL

Gene Information

Entrez Gene ID
23761
Gene Name
phosphatidylserine decarboxylase
Gene Symbol
PISD
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0005634 IDA:LIFEdb C nucleus
GO:0004609 IEA:UniProtKB-EC F phosphatidylserine decarboxylase activity
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0006646 TAS:Reactome P phosphatidylethanolamine biosynthetic process
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121401 Glycerophospholipid biosynthesis
REACT_120919 Synthesis of PE

Domain Information

InterPro Annotations

Accession Description
IPR003817 Phosphatidylserine decarboxylase-related

UniProt Annotations

Entry Information

Gene Name
phosphatidylserine decarboxylase
Protein Entry
PISD_HUMAN
UniProt ID
Q9UG56
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UG56-3; Sequence=Displayed; Name=2; IsoId=Q9UG56-2; Sequence=VSP_007540; Note=No experimental confirmation available.;
Catalytic Activity Phosphatidyl-L-serine = phosphatidylethanolamine + CO(2).
Cofactor Name=pyruvoyl group; Xref=ChEBI
Pathway Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.
Sequence Caution Sequence=CAB43678.2; Type=Erroneous translation; Evidence= ;
Similarity Belongs to the phosphatidylserine decarboxylase family.
Subcellular Location Mitochondrion .
Subunit Heterodimer.

Identical and Related Proteins

Unique RefSeq proteins for LMP006744 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13489112 RefSeq NP_055153 375 phosphatidylserine decarboxylase proenzyme

Identical Sequences to LMP006744 proteins

Reference Database Accession Length Protein Name
GI:13489112 GenBank AIC51031.1 375 PISD, partial [synthetic construct]
GI:13489112 RefSeq XP_005261517.1 375 PREDICTED: phosphatidylserine decarboxylase proenzyme isoform X6 [Homo sapiens]
GI:13489112 RefSeq XP_005261518.1 375 PREDICTED: phosphatidylserine decarboxylase proenzyme isoform X7 [Homo sapiens]
GI:13489112 RefSeq XP_006724263.1 375 PREDICTED: phosphatidylserine decarboxylase proenzyme isoform X10 [Homo sapiens]
GI:13489112 RefSeq XP_006724264.1 375 PREDICTED: phosphatidylserine decarboxylase proenzyme isoform X11 [Homo sapiens]
GI:13489112 RefSeq XP_006724265.1 375 PREDICTED: phosphatidylserine decarboxylase proenzyme isoform X12 [Homo sapiens]

Related Sequences to LMP006744 proteins

Reference Database Accession Length Protein Name
GI:13489112 RefSeq XP_001150563.1 375 PREDICTED: phosphatidylserine decarboxylase proenzyme isoform X3 [Pan troglodytes]
GI:13489112 RefSeq XP_009436471.1 375 PREDICTED: phosphatidylserine decarboxylase proenzyme isoform X3 [Pan troglodytes]
GI:13489112 RefSeq XP_009436472.1 375 PREDICTED: phosphatidylserine decarboxylase proenzyme isoform X3 [Pan troglodytes]
GI:13489112 RefSeq XP_009436473.1 375 PREDICTED: phosphatidylserine decarboxylase proenzyme isoform X3 [Pan troglodytes]
GI:13489112 RefSeq XP_009436474.1 375 PREDICTED: phosphatidylserine decarboxylase proenzyme isoform X3 [Pan troglodytes]
GI:13489112 RefSeq XP_009436475.1 375 PREDICTED: phosphatidylserine decarboxylase proenzyme isoform X3 [Pan troglodytes]