Gene/Proteome Database (LMPD)
Proteins
| acyl-coenzyme A synthetase ACSM4, mitochondrial precursor | |
|---|---|
| Refseq ID | NP_001073923 |
| Protein GI | 122937307 |
| UniProt ID | P0C7M7 |
| mRNA ID | NM_001080454 |
| Length | 580 |
| RefSeq Status | PROVISIONAL |
| MKIFFRYQTFRFIWLTKPPGRRLHKDHQLWTPLTLADFEAINRCNRPLPKNFNFAADVLDQWSQKEKTGERPANPALWWVNGKGDEVKWSFRELGSLSRKAANVLTKPCGLQRGDRLAVILPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASEEVAPAVESIVLECPDLKTKLLVSPQSWNGWLSFQELFQFASEEHSCVETGSQEPMTIYFTSGTTGFPKMAQHSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGACVFVHRMAQFDTDTFLDTLTTYPITTLCSPPTVYRMLVQKDLKRYKFKSLRHCLTGGEPLNPEVLEQWRVQTGLELYEGYGQTEVGMICANQKGQEIKPGSMGKGMLPYDVQIIDENGNVLPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTAATIRGDFYVTGDRGVMDSDGYFWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQEWRGR | |
| transit_peptide: 1..22 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (P0C7M7.1) calculated_mol_wt: 2890 peptide sequence: MKIFFRYQTFRFIWLTKPPGRR mat_peptide: 23..580 product: Acyl-coenzyme A synthetase ACSM4, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P0C7M7.1) calculated_mol_wt: 62832 peptide sequence: LHKDHQLWTPLTLADFEAINRCNRPLPKNFNFAADVLDQWSQKEKTGERPANPALWWVNGKGDEVKWSFRELGSLSRKAANVLTKPCGLQRGDRLAVILPRIPEWWLVNVACIRTGIIFMPGTIQLTAKDILYRLRASKAKCIVASEEVAPAVESIVLECPDLKTKLLVSPQSWNGWLSFQELFQFASEEHSCVETGSQEPMTIYFTSGTTGFPKMAQHSQSSLGIGFTLCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWLCGACVFVHRMAQFDTDTFLDTLTTYPITTLCSPPTVYRMLVQKDLKRYKFKSLRHCLTGGEPLNPEVLEQWRVQTGLELYEGYGQTEVGMICANQKGQEIKPGSMGKGMLPYDVQIIDENGNVLPPGKEGEIALRLKPTRPFCFFSKYVDNPQKTAATIRGDFYVTGDRGVMDSDGYFWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQEWRGR | |
Gene Information
Entrez Gene ID
Gene Name
acyl-CoA synthetase medium-chain family member 4
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005739 | IEA:UniProtKB-KW | C | mitochondrion |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0047760 | IEA:UniProtKB-EC | F | butyrate-CoA ligase activity |
| GO:0004321 | IEA:Ensembl | F | fatty-acyl-CoA synthase activity |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0006637 | IEA:Ensembl | P | acyl-CoA metabolic process |
| GO:0006631 | IEA:UniProtKB-KW | P | fatty acid metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa01100 | Metabolic pathways |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6000 | gamma-linolenate biosynthesis II (animals) |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_6812 | Conjugation of salicylate with glycine |
| REACT_6959 | Phase II conjugation |
Domain Information
UniProt Annotations
Entry Information
Gene Name
acyl-CoA synthetase medium-chain family member 4
Protein Entry
ACSM4_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA. |
| Cofactor | Name=Mg(2+); Xref=ChEBI |
| Function | Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity). |
| Similarity | Belongs to the ATP-dependent AMP-binding enzyme family. |
| Subcellular Location | Mitochondrion matrix . |
Identical and Related Proteins
Unique RefSeq proteins for LMP006754 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 122937307 | RefSeq | NP_001073923 | 580 | acyl-coenzyme A synthetase ACSM4, mitochondrial precursor |
Identical Sequences to LMP006754 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:122937307 | SwissProt | P0C7M7.1 | 580 | RecName: Full=Acyl-coenzyme A synthetase ACSM4, mitochondrial; AltName: Full=Acyl-CoA synthetase medium-chain family member 4; Flags: Precursor [Homo sapiens] |
Related Sequences to LMP006754 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:122937307 | GenBank | EHH66034.1 | 580 | Acyl-coenzyme A synthetase ACSM4, mitochondrial [Macaca fascicularis] |
| GI:122937307 | RefSeq | XP_508984.2 | 580 | PREDICTED: acyl-coenzyme A synthetase ACSM4, mitochondrial [Pan troglodytes] |
| GI:122937307 | RefSeq | XP_002822893.1 | 580 | PREDICTED: acyl-coenzyme A synthetase ACSM4, mitochondrial [Pongo abelii] |
| GI:122937307 | RefSeq | XP_003273837.1 | 580 | PREDICTED: acyl-coenzyme A synthetase ACSM4, mitochondrial [Nomascus leucogenys] |
| GI:122937307 | RefSeq | XP_003811852.1 | 597 | PREDICTED: acyl-coenzyme A synthetase ACSM4, mitochondrial [Pan paniscus] |
| GI:122937307 | RefSeq | XP_004052677.1 | 580 | PREDICTED: acyl-coenzyme A synthetase ACSM4, mitochondrial [Gorilla gorilla gorilla] |