Gene/Proteome Database (LMPD)

LMPD ID
LMP006756
Gene ID
5407
Species
Homo sapiens (Human)
Gene Name
pancreatic lipase-related protein 1
Gene Symbol
PNLIPRP1
Synonyms
PLRP1
Alternate Names
inactive pancreatic lipase-related protein 1; PL-RP1
Chromosome
10
Map Location
10q25.3

Proteins

inactive pancreatic lipase-related protein 1 precursor
Refseq ID NP_006220
Protein GI 5453920
UniProt ID P54315
mRNA ID NM_006229
Length 467
RefSeq Status PROVISIONAL
MLIFWTITLFLLGAAKGKEVCYEDLGCFSDTEPWGGTAIRPLKILPWSPEKIGTRFLLYTNENPNNFQILLLSDPSTIEASNFQMDRKTRFIIHGFIDKGDESWVTDMCKKLFEVEEVNCICVDWKKGSQATYTQAANNVRVVGAQVAQMLDILLTEYSYPPSKVHLIGHSLGAHVAGEAGSKTPGLSRITGLDPVEASFESTPEEVRLDPSDADFVDVIHTDAAPLIPFLGFGTNQQMGHLDFFPNGGESMPGCKKNALSQIVDLDGIWAGTRDFVACNHLRSYKYYLESILNPDGFAAYPCTSYKSFESDKCFPCPDQGCPQMGHYADKFAGRTSEEQQKFFLNTGEASNFARWRYGVSITLSGRTATGQIKVALFGNKGNTHQYSIFRGILKPGSTHSYEFDAKLDVGTIEKVKFLWNNNVINPTLPKVGATKITVQKGEEKTVYNFCSEDTVREDTLLTLTPC
sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1895 peptide sequence: MLIFWTITLFLLGAAKG mat_peptide: 18..467 product: inactive pancreatic lipase-related protein 1 calculated_mol_wt: 49971 peptide sequence: KEVCYEDLGCFSDTEPWGGTAIRPLKILPWSPEKIGTRFLLYTNENPNNFQILLLSDPSTIEASNFQMDRKTRFIIHGFIDKGDESWVTDMCKKLFEVEEVNCICVDWKKGSQATYTQAANNVRVVGAQVAQMLDILLTEYSYPPSKVHLIGHSLGAHVAGEAGSKTPGLSRITGLDPVEASFESTPEEVRLDPSDADFVDVIHTDAAPLIPFLGFGTNQQMGHLDFFPNGGESMPGCKKNALSQIVDLDGIWAGTRDFVACNHLRSYKYYLESILNPDGFAAYPCTSYKSFESDKCFPCPDQGCPQMGHYADKFAGRTSEEQQKFFLNTGEASNFARWRYGVSITLSGRTATGQIKVALFGNKGNTHQYSIFRGILKPGSTHSYEFDAKLDVGTIEKVKFLWNNNVINPTLPKVGATKITVQKGEEKTVYNFCSEDTVREDTLLTLTPC

Gene Information

Entrez Gene ID
5407
Gene Name
pancreatic lipase-related protein 1
Gene Symbol
PNLIPRP1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 TAS:ProtInc C extracellular region
GO:0005509 ISS:UniProtKB F calcium ion binding
GO:0004806 TAS:ProtInc F triglyceride lipase activity
GO:0006629 IEA:InterPro P lipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04975 Fat digestion and absorption
hsa04972 Pancreatic secretion

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_9518 Digestion of dietary lipid

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR013818 Lipase, N-terminal
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR016272 Lipoprotein_lipase_LIPH
IPR001024 PLAT/LH2 domain
IPR002331 Pancreatic lipase
IPR000734 Triacylglycerol lipase family

UniProt Annotations

Entry Information

Gene Name
pancreatic lipase-related protein 1
Protein Entry
LIPR1_HUMAN
UniProt ID
P54315
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P54315-1; Sequence=Displayed; Name=2; IsoId=P54315-2; Sequence=VSP_014097, VSP_014100; Name=3; IsoId=P54315-3; Sequence=VSP_014098, VSP_014099;
Function May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).
Similarity Belongs to the AB hydrolase superfamily. Lipase family.
Similarity Contains 1 PLAT domain. {ECO
Subcellular Location Secreted {ECO
Tissue Specificity Pancreas.

Identical and Related Proteins

Unique RefSeq proteins for LMP006756 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
5453920 RefSeq NP_006220 467 inactive pancreatic lipase-related protein 1 precursor

Identical Sequences to LMP006756 proteins

Reference Database Accession Length Protein Name
GI:5453920 GenBank ACP57496.1 467 Sequence 1625 from patent US 7482117
GI:5453920 GenBank ACP57497.1 467 Sequence 1626 from patent US 7482117
GI:5453920 GenBank ADS31093.1 467 Sequence 1625 from patent US 7781168
GI:5453920 GenBank ADS31094.1 467 Sequence 1626 from patent US 7781168
GI:5453920 GenBank AHD76069.1 467 Sequence 18893 from patent US 8586006
GI:5453920 RefSeq XP_005269960.1 467 PREDICTED: inactive pancreatic lipase-related protein 1 isoform X1 [Homo sapiens]

Related Sequences to LMP006756 proteins

Reference Database Accession Length Protein Name
GI:5453920 GenBank AAH25784.1 467 Pancreatic lipase-related protein 1 [Homo sapiens]
GI:5453920 RefSeq XP_001094807.2 497 PREDICTED: pancreatic lipase-related protein 1 isoform 2 [Macaca mulatta]
GI:5453920 RefSeq XP_003255039.1 467 PREDICTED: pancreatic lipase-related protein 1 isoform 1 [Nomascus leucogenys]
GI:5453920 RefSeq XP_003255040.1 467 PREDICTED: pancreatic lipase-related protein 1 isoform 2 [Nomascus leucogenys]
GI:5453920 RefSeq XP_002821220.2 480 PREDICTED: inactive pancreatic lipase-related protein 1 isoform X1 [Pongo abelii]
GI:5453920 RefSeq XP_005566588.1 497 PREDICTED: inactive pancreatic lipase-related protein 1 [Macaca fascicularis]