Gene/Proteome Database (LMPD)
LMPD ID
LMP006757
Gene ID
Species
Homo sapiens (Human)
Gene Name
phosphatidylethanolamine-binding protein 4
Gene Symbol
Synonyms
CORK-1; CORK1; GWTM1933; HEL-S-300; PEBP-4; PRO4408; hPEBP4
Alternate Names
phosphatidylethanolamine-binding protein 4; cousin-of-RKIP 1 protein; protein cousin-of-RKIP 1; epididymis secretory protein Li 300
Chromosome
8
Map Location
8p21.3
Summary
The phosphatidylethanolamine (PE)-binding proteins, including PEBP4, are an evolutionarily conserved family of proteins with pivotal biologic functions, such as lipid binding and inhibition of serine proteases (Wang et al., 2004 [PubMed 15302887]).[supplied by OMIM, Dec 2008]
Orthologs
Proteins
| phosphatidylethanolamine-binding protein 4 precursor | |
|---|---|
| Refseq ID | NP_659399 |
| Protein GI | 116812622 |
| UniProt ID | Q96S96 |
| mRNA ID | NM_144962 |
| Length | 227 |
| RefSeq Status | VALIDATED |
| MGWTMRLVTAALLLGLMMVVTGDEDENSPCAHEALLDEDTLFCQGLEVFYPELGNIGCKVVPDCNNYRQKITSWMEPIVKFPGAVDGATYILVMVDPDAPSRAEPRQRFWRHWLVTDIKGADLKKGKIQGQELSAYQAPSPPAHSGFHRYQFFVYLQEGKVISLLPKENKTRGSWKMDRFLNRFHLGEPEASTQFMTQNYQDSPTLQAPRERASEPKHKNQAEIAAC | |
| sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2365 peptide sequence: MGWTMRLVTAALLLGLMMVVTG mat_peptide: 23..227 product: Phosphatidylethanolamine-binding protein 4 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q96S96.3) calculated_mol_wt: 23387 peptide sequence: DEDENSPCAHEALLDEDTLFCQGLEVFYPELGNIGCKVVPDCNNYRQKITSWMEPIVKFPGAVDGATYILVMVDPDAPSRAEPRQRFWRHWLVTDIKGADLKKGKIQGQELSAYQAPSPPAHSGFHRYQFFVYLQEGKVISLLPKENKTRGSWKMDRFLNRFHLGEPEASTQFMTQNYQDSPTLQAPRERASEPKHKNQAEIAAC | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylethanolamine-binding protein 4
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0070062 | IDA:UniProtKB | C | extracellular vesicular exosome |
| GO:0005764 | IEA:UniProtKB-KW | C | lysosome |
Domain Information
UniProt Annotations
Entry Information
Gene Name
phosphatidylethanolamine-binding protein 4
Protein Entry
PEBP4_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Function | Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization. |
| Interaction | P31749:AKT1; NbExp=2; IntAct=EBI-8563667, EBI-296087; P04049:RAF1; NbExp=4; IntAct=EBI-8563667, EBI-365996; |
| Sequence Caution | Sequence=AAH20779.1; Type=Frameshift; Positions=219; Evidence= ; Sequence=AAQ89467.1; Type=Frameshift; Positions=219; Evidence= ; |
| Similarity | Belongs to the phosphatidylethanolamine-binding protein family. |
| Subcellular Location | Lysosome . |
| Tissue Specificity | Ubiquitously expressed. Highly expressed in tumor cells. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006757 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 116812622 | RefSeq | NP_659399 | 227 | phosphatidylethanolamine-binding protein 4 precursor |
Identical Sequences to LMP006757 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:116812622 | DBBJ | BAJ21137.1 | 227 | phosphatidylethanolamine-binding protein 4, partial [synthetic construct] |
| GI:116812622 | EMBL | CAT16638.1 | 227 | unnamed protein product [Homo sapiens] |
| GI:116812622 | GenBank | ABJ43358.1 | 227 | Sequence 8 from patent US 7115416 |
| GI:116812622 | GenBank | ABU31499.1 | 227 | Sequence 8 from patent US 7235381 |
| GI:116812622 | GenBank | ACJ87459.1 | 227 | Sequence 8 from patent US 7413875 |
| GI:116812622 | SwissProt | Q96S96.3 | 227 | RecName: Full=Phosphatidylethanolamine-binding protein 4; Short=PEBP-4; Short=hPEBP4; AltName: Full=Protein cousin-of-RKIP 1; Flags: Precursor [Homo sapiens] |
Related Sequences to LMP006757 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:116812622 | EMBL | CAC24866.1 | 227 | unnamed protein product [Homo sapiens] |
| GI:116812622 | GenBank | AAK67629.1 | 227 | phosphatidylethanolamine binding protein [Homo sapiens] |
| GI:116812622 | GenBank | AAW56965.1 | 227 | cousin-of-RKIP 1 protein [Homo sapiens] |
| GI:116812622 | GenBank | ACE21594.1 | 227 | Sequence 6825 from patent US 7368531 |
| GI:116812622 | GenBank | ACH32345.1 | 227 | Sequence 6825 from patent US 7411051 |
| GI:116812622 | GenBank | ACN00278.1 | 223 | Sequence 232 from patent US 7476723 |