Gene/Proteome Database (LMPD)

LMPD ID
LMP006760
Gene ID
145482
Species
Homo sapiens (Human)
Gene Name
prostaglandin reductase 2
Gene Symbol
PTGR2
Synonyms
HEL-S-298; PGR2; ZADH1
Alternate Names
prostaglandin reductase 2; PRG-2; 15-oxoprostaglandin 13-reductase; epididymis secretory protein Li 298; 15-oxoprostaglandin-delta13-reductase; zinc binding alcohol dehydrogenase, domain containing 1; zinc-binding alcohol dehydrogenase domain-containing protein 1
Chromosome
14
Map Location
14q24.3
EC Number
1.3.1.48
Summary
This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Orthologs
View orthologs and multiple alignments for PTGR2

Proteins

prostaglandin reductase 2
Refseq ID NP_001139626
Protein GI 226246680
UniProt ID Q8N8N7
mRNA ID NM_001146154
Length 351
RefSeq Status REVIEWED
MIVQRVVLNSRPGKNGNPVAENFRMEEVYLPDNINEGQVQVRTLYLSVDPYMRCRMNEDTGTDYITPWQLSQVVDGGGIGIIEESKHTNLTKGDFVTSFYWPWQTKVILDGNSLEKVDPQLVDGHLSYFLGAIGMPGLTSLIGIQEKGHITAGSNKTMVVSGAAGACGSVAGQIGHFLGCSRVVGICGTHEKCILLTSELGFDAAINYKKDNVAEQLRESCPAGVDVYFDNVGGNISDTVISQMNENSHIILCGQISQYNKDVPYPPPLSPAIEAIQKERNITRERFLVLNYKDKFEPGILQLSQWFKEGKLKIKETVINGLENMGAAFQSMMTGGNIGKQIVCISEEISL
prostaglandin reductase 2
Refseq ID NP_001139627
Protein GI 226246682
UniProt ID Q8N8N7
mRNA ID NM_001146155
Length 351
RefSeq Status REVIEWED
Protein sequence is identical to GI:226246680 (mRNA isoform)
prostaglandin reductase 2
Refseq ID NP_689657
Protein GI 22748929
UniProt ID Q8N8N7
mRNA ID NM_152444
Length 351
RefSeq Status REVIEWED
Protein sequence is identical to GI:226246680 (mRNA isoform)

Gene Information

Entrez Gene ID
145482
Gene Name
prostaglandin reductase 2
Gene Symbol
PTGR2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0036132 IEA:UniProtKB-EC F 13-prostaglandin reductase activity
GO:0047522 IDA:UniProtKB F 15-oxoprostaglandin 13-oxidase activity
GO:0006693 IDA:UniProtKB P prostaglandin metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR002085 Alcohol dehydrogenase superfamily, zinc-type
IPR013149 Alcohol dehydrogenase, C-terminal
IPR011032 GroES (chaperonin 10)-like
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
prostaglandin reductase 2
Protein Entry
PTGR2_HUMAN
UniProt ID
Q8N8N7
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=ZADH1b; IsoId=Q8N8N7-1; Sequence=Displayed; Name=2; IsoId=Q8N8N7-2; Sequence=VSP_013526, VSP_013527; Note=No experimental confirmation available.;
Biophysicochemical Properties Kinetic parameters: KM=11.21 uM for 15-keto-PGE2 ; KM=15.87 uM for NADPH ; Vmax=159 nmol/min/mg enzyme for 15-keto-PGE2 ; Vmax=67 nmol/min/mg enzyme for NADPH ;
Catalytic Activity 11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13- dienoate + NAD(P)H.
Function Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).
Similarity Belongs to the NADP-dependent oxidoreductase L4BD family.
Subcellular Location Cytoplasm .
Subunit Monomer.
Tissue Specificity Widely expressed.

Identical and Related Proteins

Unique RefSeq proteins for LMP006760 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
226246680 RefSeq NP_001139626 351 prostaglandin reductase 2

Identical Sequences to LMP006760 proteins

Reference Database Accession Length Protein Name
GI:226246680 GenBank JAA08554.1 351 prostaglandin reductase 2 [Pan troglodytes]
GI:226246680 GenBank JAA17515.1 351 prostaglandin reductase 2 [Pan troglodytes]
GI:226246680 GenBank JAA24578.1 351 prostaglandin reductase 2 [Pan troglodytes]
GI:226246680 GenBank JAA41588.1 351 prostaglandin reductase 2 [Pan troglodytes]
GI:226246680 GenBank AHD76884.1 351 Sequence 21104 from patent US 8586006
GI:226246680 GenBank AIC57764.1 351 PTGR2, partial [synthetic construct]

Related Sequences to LMP006760 proteins

Reference Database Accession Length Protein Name
GI:226246680 EMBL CAH92104.1 435 hypothetical protein, partial [Pongo abelii]
GI:226246680 PDB 2W4Q 357 Chain A, Crystal Structure Of Human Zinc-binding Alcohol Dehydrogenase 1 (zadh1) In Ternary Complex With Nadp And 18beta-glycyrrhetinic Acid
GI:226246680 PDB 2VNA 357 Chain A, Structure Of Human Zinc-Binding Alcohol Dehydrogenase 1 ( Zadh1)
GI:226246680 PDB 2W98 357 Chain A, Crystal Structure Of Human Zinc-binding Alcohol Dehydrogenase 1 (zadh1) In Ternary Complex With Nadp And Phenylbutazone
GI:226246680 PDB 2W98 357 Chain B, Crystal Structure Of Human Zinc-binding Alcohol Dehydrogenase 1 (zadh1) In Ternary Complex With Nadp And Phenylbutazone
GI:226246680 SwissProt Q5R806.2 351 RecName: Full=Prostaglandin reductase 2; Short=PRG-2; AltName: Full=15-oxoprostaglandin 13-reductase [Pongo abelii]