Gene/Proteome Database (LMPD)
LMPD ID
LMP006762
Gene ID
Species
Homo sapiens (Human)
Gene Name
ethanolamine kinase 2
Gene Symbol
Synonyms
EKI2; HMFT1716
Chromosome
1
Map Location
1q32.1
EC Number
2.7.1.82
Summary
The protein encoded by this gene is a member of choline/ethanolamine kinase family which catalyzes the first step of phosphatidylethanolamine (PtdEtn) biosynthesis via the cytidine diphosphate (CDP) ethanolamine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Orthologs
Proteins
| ethanolamine kinase 2 isoform 1 | |
|---|---|
| Refseq ID | NP_060678 |
| Protein GI | 186659525 |
| UniProt ID | Q9NVF9 |
| mRNA ID | NM_018208 |
| Length | 386 |
| RefSeq Status | REVIEWED |
| MAVPPSAPQPRASFHLRRHTPCPQCSWGMEEKAAASASCREPPGPPRAAAVAYFGISVDPDDILPGALRLIQELRPHWKPEQVRTKRFTDGITNKLVACYVEEDMQDCVLVRVYGERTELLVDRENEVRNFQLLRAHSCAPKLYCTFQNGLCYEYMQGVALEPEHIREPRLFRLIALEMAKIHTIHANGSLPKPILWHKMHNYFTLVKNEINPSLSADVPKVEVLERELAWLKEHLSQLESPVVFCHNDLLCKNIIYDSIKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVNEVDYCLYPARETQLQWLHYYLQAQKGMAVTPREVQRLYVQVNKFALASHFFWALWALIQNQYSTIDFDFLRYAVIRFNQYFKVKPQASALEMPK | |
| ethanolamine kinase 2 isoform 2 | |
|---|---|
| Refseq ID | NP_001284689 |
| Protein GI | 663071168 |
| UniProt ID | Q9NVF9 |
| mRNA ID | NM_001297760 |
| Length | 394 |
| RefSeq Status | REVIEWED |
| MAVPPSAPQPRASFHLRRHTPCPQCSWGMEEKAAASASCREPPGPPRAAAVAYFGISVDPDDILPGALRLIQELRPHWKPEQVRTKRFTDGITNKLVACYVEEDMQDCVLVRVYGERTELLVDRENEVRNFQLLRAHSCAPKLYCTFQNGLCYEYMQGVALEPEHIREPRLFRLIALEMAKIHTIHANGSLPKPILWHKMHNYFTLVKNEINPSLSADVPKVEVLERELAWLKEHLSQLESPVVFCHNDLLCKNIIYDSIKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVNEVDYCLYPARETQLQWLHYYLQAQKGMAVTPREVQRLYVQVNKFALGPSCVSSTMTASLQCCRVGNRHGEIARLTLSGLFPGVSLLLGSLGPHPEPVLHHRL | |
| ethanolamine kinase 2 isoform 3 | |
|---|---|
| Refseq ID | NP_001284690 |
| Protein GI | 663071170 |
| UniProt ID | Q9NVF9 |
| mRNA ID | NM_001297761 |
| Length | 208 |
| RefSeq Status | REVIEWED |
| MAKIHTIHANGSLPKPILWHKMHNYFTLVKNEINPSLSADVPKVEVLERELAWLKEHLSQLESPVVFCHNDLLCKNIIYDSIKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVNEVDYCLYPARETQLQWLHYYLQAQKGMAVTPREVQRLYVQVNKFALASHFFWALWALIQNQYSTIDFDFLRYAVIRFNQYFKVKPQASALEMPK | |
| ethanolamine kinase 2 isoform 4 | |
|---|---|
| Refseq ID | NP_001284691 |
| Protein GI | 663071170 |
| UniProt ID | Q9NVF9 |
| mRNA ID | NM_001297762 |
| Length | 208 |
| RefSeq Status | REVIEWED |
| MAKIHTIHANGSLPKPILWHKMHNYFTLVKNEINPSLSADVPKVEVLERELAWLKEHLSQLESPVVFCHNDLLCKNIIYDSIKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVNEVDYCLYPARETQLQWLHYYLQAQKGMAVTPREVQRLYVQVNKFALASHFFWALWALIQNQYSTIDFDFLRYAVIRFNQYFKVKPQASALEMPK | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0004305 | IEA:UniProtKB-EC | F | ethanolamine kinase activity |
| GO:0046474 | TAS:Reactome | P | glycerophospholipid biosynthetic process |
| GO:0001701 | IEA:Ensembl | P | in utero embryonic development |
| GO:0035264 | IEA:Ensembl | P | multicellular organism growth |
| GO:0006646 | TAS:Reactome | P | phosphatidylethanolamine biosynthetic process |
| GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
| GO:0001890 | IEA:Ensembl | P | placenta development |
| GO:0009791 | IEA:Ensembl | P | post-embryonic development |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00564 | Glycerophospholipid metabolism |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_121401 | Glycerophospholipid biosynthesis |
| REACT_120919 | Synthesis of PE |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR011009 | Protein kinase-like domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NVF9-1; Sequence=Displayed; Name=2; IsoId=Q9NVF9-2; Sequence=VSP_039098; Name=3; IsoId=Q9NVF9-3; Sequence=VSP_039558; Note=No experimental confirmation available.; |
| Catalytic Activity | ATP + ethanolamine = ADP + O- phosphoethanolamine. |
| Function | Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity). |
| Pathway | Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3. |
| Sequence Caution | Sequence=BAH13637.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; |
| Similarity | Belongs to the choline/ethanolamine kinase family. |
| Tissue Specificity | Expressed in kidney, liver, ovary, testis and prostate. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006762 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 186659525 | RefSeq | NP_060678 | 386 | ethanolamine kinase 2 isoform 1 |
| 663071168 | RefSeq | NP_001284689 | 394 | ethanolamine kinase 2 isoform 2 |
| 663071170 | RefSeq | NP_001284690 | 208 | ethanolamine kinase 2 isoform 3 |
| 663071170 | RefSeq | NP_001284691 | 208 | ethanolamine kinase 2 isoform 4 |
Identical Sequences to LMP006762 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:663071170 | DBBJ | BAH11503.1 | 208 | unnamed protein product [Homo sapiens] |
| GI:663071170 | DBBJ | BAH11503.1 | 208 | unnamed protein product [Homo sapiens] |
| GI:663071170 | DBBJ | BAH14864.1 | 208 | unnamed protein product [Homo sapiens] |
| GI:663071170 | DBBJ | BAH14864.1 | 208 | unnamed protein product [Homo sapiens] |
| GI:663071168 | EMBL | CAD34944.1 | 394 | unnamed protein product [Homo sapiens] |
| GI:663071168 | GenBank | EAW91501.1 | 394 | ethanolamine kinase 2, isoform CRA_a [Homo sapiens] |
| GI:663071168 | GenBank | EAW91503.1 | 394 | ethanolamine kinase 2, isoform CRA_a [Homo sapiens] |
| GI:186659525 | GenBank | EAW91504.1 | 386 | ethanolamine kinase 2, isoform CRA_b [Homo sapiens] |
| GI:186659525 | GenBank | JAA36714.1 | 386 | ethanolamine kinase 2 [Pan troglodytes] |
| GI:186659525 | GenBank | AIC51742.1 | 386 | ETNK2, partial [synthetic construct] |
| GI:186659525 | GenBank | AIC62765.1 | 386 | ETNK2, partial [synthetic construct] |
| GI:186659525 | RefSeq | XP_003308752.3 | 386 | PREDICTED: ethanolamine kinase 2 [Pan troglodytes] |
| GI:186659525 | SwissProt | Q9NVF9.3 | 386 | RecName: Full=Ethanolamine kinase 2; Short=EKI 2; AltName: Full=Ethanolamine kinase-like protein [Homo sapiens] |
Related Sequences to LMP006762 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:663071168 | DBBJ | BAA91793.1 | 394 | unnamed protein product [Homo sapiens] |
| GI:663071168 | EMBL | CAE89587.1 | 394 | unnamed protein product [Homo sapiens] |
| GI:663071170 | GenBank | EAW91502.1 | 386 | ethanolamine kinase 2, isoform CRA_b [Homo sapiens] |
| GI:663071170 | GenBank | EAW91502.1 | 386 | ethanolamine kinase 2, isoform CRA_b [Homo sapiens] |
| GI:663071170 | GenBank | EAW91504.1 | 386 | ethanolamine kinase 2, isoform CRA_b [Homo sapiens] |
| GI:663071170 | GenBank | EAW91504.1 | 386 | ethanolamine kinase 2, isoform CRA_b [Homo sapiens] |
| GI:663071168 | GenBank | AHD79048.1 | 394 | Sequence 28692 from patent US 8586006 |
| GI:663071170 | GenBank | AIC51742.1 | 386 | ETNK2, partial [synthetic construct] |
| GI:663071170 | GenBank | AIC51742.1 | 386 | ETNK2, partial [synthetic construct] |
| GI:663071170 | GenBank | AIC62765.1 | 386 | ETNK2, partial [synthetic construct] |
| GI:663071170 | GenBank | AIC62765.1 | 386 | ETNK2, partial [synthetic construct] |
| GI:663071170 | RefSeq | NP_060678.2 | 386 | ethanolamine kinase 2 isoform 1 [Homo sapiens] |
| GI:663071170 | RefSeq | NP_060678.2 | 386 | ethanolamine kinase 2 isoform 1 [Homo sapiens] |
| GI:186659525 | RefSeq | NP_001247447.1 | 386 | ethanolamine kinase 2 [Macaca mulatta] |
| GI:186659525 | RefSeq | XP_003823020.1 | 420 | PREDICTED: ethanolamine kinase 2 isoform X2 [Pan paniscus] |
| GI:663071168 | RefSeq | XP_003823021.1 | 428 | PREDICTED: ethanolamine kinase 2 isoform X1 [Pan paniscus] |
| GI:186659525 | RefSeq | XP_003893304.1 | 386 | PREDICTED: ethanolamine kinase 2 isoform X2 [Papio anubis] |
| GI:186659525 | RefSeq | XP_004028265.1 | 456 | PREDICTED: ethanolamine kinase 2 isoform 1 [Gorilla gorilla gorilla] |
| GI:663071168 | RefSeq | XP_004028266.1 | 464 | PREDICTED: ethanolamine kinase 2 isoform 2 [Gorilla gorilla gorilla] |
| GI:186659525 | RefSeq | XP_007987032.1 | 386 | PREDICTED: ethanolamine kinase 2 isoform X3 [Chlorocebus sabaeus] |
| GI:663071170 | RefSeq | XP_003308752.3 | 386 | PREDICTED: ethanolamine kinase 2 [Pan troglodytes] |
| GI:663071170 | RefSeq | XP_003308752.3 | 386 | PREDICTED: ethanolamine kinase 2 [Pan troglodytes] |
| GI:663071168 | RefSeq | XP_010368106.1 | 394 | PREDICTED: ethanolamine kinase 2 isoform X2 [Rhinopithecus roxellana] |
| GI:186659525 | RefSeq | XP_010368107.1 | 386 | PREDICTED: ethanolamine kinase 2 isoform X3 [Rhinopithecus roxellana] |