Gene/Proteome Database (LMPD)
LMPD ID
LMP006766
Gene ID
Species
Homo sapiens (Human)
Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 9
Gene Symbol
Synonyms
AGPAT 10; AGPAT8; GPAT3; LPAAT-theta; MAG1
Alternate Names
glycerol-3-phosphate acyltransferase 3; MAG-1; GPAT-3; hGPAT3; 1-AGPAT 9; 1-AGP acyltransferase 9; endoplasmic reticulum associated GPAT; lung cancer metastasis-associated protein 1; lysophosphatidic acid acyltransferase theta; lysophosphatidic acid acyltransferase, theta; 1-acylglycerol-3-phosphate O-acyltransferase 8; acyl-CoA:glycerol-3-phosphate acyltransferase 3; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10
Chromosome
4
Map Location
4q21.23
EC Number
2.3.1.15
Summary
This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]
Orthologs
Proteins
| glycerol-3-phosphate acyltransferase 3 | |
|---|---|
| Refseq ID | NP_116106 |
| Protein GI | 21362092 |
| UniProt ID | Q53EU6 |
| mRNA ID | NM_032717 |
| Length | 434 |
| RefSeq Status | VALIDATED |
| MEGAELAGKILSTWLTLVLGFILLPSVFGVSLGISEIYMKILVKTLEWATIRIEKGTPKESILKNSASVGIIQRDESPMEKGLSGLRGRDFELSDVFYFSKKGLEAIVEDEVTQRFSSEELVSWNLLTRTNVNFQYISLRLTMVWVLGVIVRYCVLLPLRVTLAFIGISLLVIGTTLVGQLPDSSLKNWLSELVHLTCCRICVRALSGTIHYHNKQYRPQKGGICVANHTSPIDVLILTTDGCYAMVGQVHGGLMGIIQRAMVKACPHVWFERSEMKDRHLVTKRLKEHIADKKKLPILIFPEGTCINNTSVMMFKKGSFEIGGTIHPVAIKYNPQFGDAFWNSSKYNMVSYLLRMMTSWAIVCDVWYMPPMTREEGEDAVQFANRVKSAIAIQGGLTELPWDGGLKRAKVKDIFKEEQQKNYSKMIVGNGSLS | |
| glycerol-3-phosphate acyltransferase 3 | |
|---|---|
| Refseq ID | NP_001243350 |
| Protein GI | 374088031 |
| UniProt ID | Q53EU6 |
| mRNA ID | NM_001256421 |
| Length | 434 |
| RefSeq Status | VALIDATED |
| Protein sequence is identical to GI:21362092 (mRNA isoform) | |
| glycerol-3-phosphate acyltransferase 3 | |
|---|---|
| Refseq ID | NP_001243351 |
| Protein GI | 374088036 |
| UniProt ID | Q53EU6 |
| mRNA ID | NM_001256422 |
| Length | 434 |
| RefSeq Status | VALIDATED |
| Protein sequence is identical to GI:21362092 (mRNA isoform) | |
Gene Information
Entrez Gene ID
Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 9
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IDA:UniProtKB | C | endoplasmic reticulum |
| GO:0005789 | IDA:UniProtKB | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0003841 | IEA:UniProtKB-EC | F | 1-acylglycerol-3-phosphate O-acyltransferase activity |
| GO:0004366 | IDA:UniProtKB | F | glycerol-3-phosphate O-acyltransferase activity |
| GO:0016024 | IEA:UniProtKB-UniPathway | P | CDP-diacylglycerol biosynthetic process |
| GO:0044255 | TAS:Reactome | P | cellular lipid metabolic process |
| GO:0046474 | TAS:Reactome | P | glycerophospholipid biosynthetic process |
| GO:0006654 | TAS:Reactome | P | phosphatidic acid biosynthetic process |
| GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
| GO:0032006 | IDA:UniProtKB | P | regulation of TOR signaling |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0019432 | IDA:UniProtKB | P | triglyceride biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00561 | Glycerolipid metabolism |
| hsa00564 | Glycerophospholipid metabolism |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_120906 | Synthesis of PA |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR002123 | Phospholipid/glycerol acyltransferase |
UniProt Annotations
Entry Information
Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 9
Protein Entry
GPAT3_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. |
| Catalytic Activity | Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1- acyl-sn-glycerol 3-phosphate. |
| Caution | Despite its name, this protein appears to lack measurable glycerol-3-phosphate acyltransferase activity under some conditions (PMID |
| Domain | The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. |
| Enzyme Regulation | Inhibited by N-ethylmaleimide (NEM). |
| Function | May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Also transfers the acyl-group from acyl-coA to the sn-2 position of 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid, or PA). {ECO |
| Pathway | Glycerolipid metabolism; triacylglycerol biosynthesis. |
| Pathway | Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3. |
| Similarity | Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. |
| Subcellular Location | Endoplasmic reticulum membrane ; Multi- pass membrane protein {ECO |
| Tissue Specificity | Widely expressed. Expressed in liver, kidney, testis, brain, heart, skeletal muscle, thyroid, prostate, thymus and placenta. Also expressed lung and adipose tissue. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006766 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 21362092 | RefSeq | NP_116106 | 434 | glycerol-3-phosphate acyltransferase 3 |
Identical Sequences to LMP006766 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:21362092 | EMBL | CBX47664.1 | 434 | unnamed protein product [Homo sapiens] |
| GI:21362092 | GenBank | ADR96964.1 | 434 | Sequence 382 from patent US 7749695 |
| GI:21362092 | GenBank | AHL57978.1 | 434 | Sequence 488 from patent US 8647822 |
| GI:21362092 | RefSeq | XP_002814985.1 | 434 | PREDICTED: glycerol-3-phosphate acyltransferase 3 isoform X1 [Pongo abelii] |
| GI:21362092 | RefSeq | NP_001243350.1 | 434 | glycerol-3-phosphate acyltransferase 3 [Homo sapiens] |
| GI:21362092 | RefSeq | NP_001243351.1 | 434 | glycerol-3-phosphate acyltransferase 3 [Homo sapiens] |
Related Sequences to LMP006766 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:21362092 | DBBJ | BAD97263.1 | 434 | hypothetical protein MGC11324 variant, partial [Homo sapiens] |
| GI:21362092 | RefSeq | XP_001134987.1 | 434 | PREDICTED: glycerol-3-phosphate acyltransferase 3 isoform X2 [Pan troglodytes] |
| GI:21362092 | RefSeq | XP_003265890.1 | 434 | PREDICTED: glycerol-3-phosphate acyltransferase 3 isoform 1 [Nomascus leucogenys] |
| GI:21362092 | RefSeq | XP_004089056.1 | 434 | PREDICTED: glycerol-3-phosphate acyltransferase 3 isoform 2 [Nomascus leucogenys] |
| GI:21362092 | RefSeq | XP_005263371.1 | 526 | PREDICTED: glycerol-3-phosphate acyltransferase 3 isoform X1 [Homo sapiens] |
| GI:21362092 | RefSeq | XP_009445897.1 | 434 | PREDICTED: glycerol-3-phosphate acyltransferase 3 isoform X2 [Pan troglodytes] |