Gene/Proteome Database (LMPD)

LMPD ID
LMP006776
Gene ID
138429
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol-4-phosphate 5-kinase-like 1
Gene Symbol
PIP5KL1
Synonyms
PIPKH; bA203J24.5
Alternate Names
phosphatidylinositol 4-phosphate 5-kinase-like protein 1; PI(4)P 5-kinase-like protein 1; ptdIns(4)P-5-kinase-like protein 1; phosphatidylinositol phosphate kinase homolog; phosphatidylinositol-4-phosphate 5-kinase-like protein 1
Chromosome
9
Map Location
9q34.11
EC Number
2.7.1.68
Summary
PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 [PubMed 14701839]).[supplied by OMIM, Jun 2009]
Orthologs
View orthologs and multiple alignments for PIP5KL1

Proteins

phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 1
Refseq ID NP_001128691
Protein GI 206725454
UniProt ID Q5T9C9
mRNA ID NM_001135219
Length 394
RefSeq Status VALIDATED
MAAPSPGPREVLAPSPEAGCRAVTSSRRGLLWRLRDKQSRLGLFEISPGHELHGMTCMMQAGLWAATQVSMDHPPTGPPSRDDFSEVLTQVHEGFELGTLAGPAFAWLRRSLGLAEEDYQAALGPGGPYLQFLSTSKSKASFFLSHDQRFFLKTQGRREVQALLAHLPRYVQHLQRHPHSLLARLLGVHSLRVDRGKKTYFIVMQSVFYPAGRISERYDIKGCEVSRWVDPAPEGSPLVLVLKDLNFQGKTINLGPQRSWFLRQMELDTTFLRELNVLDYSLLIAFQRLHEDERGPGSSLIFRTARSVQGAQSPEESRAQNRRLLPDAPNALHILDGPEQRYFLGVVDLATVYGLRKRLEHLWKTLRYPGRTFSTVSPARYARRLCQWVEAHTE
phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 2
Refseq ID NP_775763
Protein GI 27735085
UniProt ID Q5T9C9
mRNA ID NM_173492
Length 191
RefSeq Status VALIDATED
MQSVFYPAGRISERYDIKGCEVSRWVDPAPEGSPLVLVLKDLNFQGKTINLGPQRSWFLRQMELDTTFLRELNVLDYSLLIAFQRLHEDERGPGSSLIFRTARSVQGAQSPEESRAQNRRLLPDAPNALHILDGPEQRYFLGVVDLATVYGLRKRLEHLWKTLRYPGRTFSTVSPARYARRLCQWVEAHTE

Gene Information

Entrez Gene ID
138429
Gene Name
phosphatidylinositol-4-phosphate 5-kinase-like 1
Gene Symbol
PIP5KL1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042995 IEA:Ensembl C cell projection
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0016308 IEA:UniProtKB-EC F 1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding

KEGG Pathway Links

KEGG Pathway ID Description
hsa04144 Endocytosis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6352 3-phosphoinositide biosynthesis
PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR023610 Phosphatidylinositol-4-phosphate 5-kinase
IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-4-phosphate 5-kinase-like 1
Protein Entry
PI5L1_HUMAN
UniProt ID
Q5T9C9
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5T9C9-1; Sequence=Displayed; Name=2; IsoId=Q5T9C9-2; Sequence=VSP_024904; Note=No experimental confirmation available.;
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Caution It is unsure if the enzyme has intrinsic kinase activity.
Function May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.
Similarity Contains 1 PIPK domain. {ECO
Subcellular Location Cytoplasm. Membrane. Note=Localized to large cytoplasmic vesicular structures.
Subunit Heterodimerizes with other type I phosphatidylinositol 4- phosphate 5-kinase.

Identical and Related Proteins

Unique RefSeq proteins for LMP006776 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
206725454 RefSeq NP_001128691 394 phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 1
27735085 RefSeq NP_775763 191 phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 2

Identical Sequences to LMP006776 proteins

Reference Database Accession Length Protein Name
GI:27735085 GenBank AAH42184.1 191 Phosphatidylinositol-4-phosphate 5-kinase-like 1 [Homo sapiens]
GI:206725454 GenBank EAW87724.1 394 phosphatidylinositol-4-phosphate 5-kinase-like 1, isoform CRA_c [Homo sapiens]
GI:27735085 GenBank EAW87728.1 191 phosphatidylinositol-4-phosphate 5-kinase-like 1, isoform CRA_g [Homo sapiens]
GI:27735085 GenBank ADQ32978.1 191 phosphatidylinositol-4-phosphate 5-kinase-like 1, partial [synthetic construct]
GI:27735085 GenBank AIC53107.1 191 PIP5KL1, partial [synthetic construct]
GI:27735085 GenBank AIC62876.1 191 PIP5KL1, partial [synthetic construct]
GI:206725454 SwissProt Q5T9C9.2 394 RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase-like protein 1; Short=PI(4)P 5-kinase-like protein 1; Short=PtdIns(4)P-5-kinase-like protein 1 [Homo sapiens]

Related Sequences to LMP006776 proteins

Reference Database Accession Length Protein Name
GI:27735085 GenBank EAW87724.1 394 phosphatidylinositol-4-phosphate 5-kinase-like 1, isoform CRA_c [Homo sapiens]
GI:27735085 GenBank JAA01259.1 394 phosphatidylinositol-4-phosphate 5-kinase-like 1 [Pan troglodytes]
GI:206725454 GenBank JAA01259.1 394 phosphatidylinositol-4-phosphate 5-kinase-like 1 [Pan troglodytes]
GI:27735085 GenBank JAA33198.1 394 phosphatidylinositol-4-phosphate 5-kinase-like 1 [Pan troglodytes]
GI:206725454 GenBank JAA33198.1 394 phosphatidylinositol-4-phosphate 5-kinase-like 1 [Pan troglodytes]
GI:27735085 RefSeq NP_001128691.1 394 phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 1 [Homo sapiens]
GI:206725454 RefSeq XP_002820287.1 394 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [Pongo abelii]
GI:27735085 RefSeq XP_003822355.1 394 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [Pan paniscus]
GI:206725454 RefSeq XP_003822355.1 394 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [Pan paniscus]
GI:206725454 RefSeq XP_006717019.1 486 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [Homo sapiens]
GI:206725454 RefSeq XP_520281.3 426 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X4 [Pan troglodytes]
GI:27735085 SwissProt Q5T9C9.2 394 RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase-like protein 1; Short=PI(4)P 5-kinase-like protein 1; Short=PtdIns(4)P-5-kinase-like protein 1 [Homo sapiens]