Gene/Proteome Database (LMPD)

LMPD ID
LMP006802
Gene ID
114876
Species
Homo sapiens (Human)
Gene Name
oxysterol binding protein-like 1A
Gene Symbol
OSBPL1A
Synonyms
ORP-1; ORP1; OSBPL1B
Chromosome
18
Map Location
18q11.1
Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for OSBPL1A

Proteins

oxysterol-binding protein-related protein 1 isoform 1
Refseq ID NP_060500
Protein GI 19718746
UniProt ID Q9BXW6
mRNA ID NM_018030
Length 437
RefSeq Status REVIEWED
MSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSYWDRNYFNLPDIY
oxysterol-binding protein-related protein 1 isoform 2
Refseq ID NP_542164
Protein GI 19718741
UniProt ID Q9BXW6
mRNA ID NM_080597
Length 950
RefSeq Status REVIEWED
MNTEAEQQLLHHARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEVTHAEEIRSMLEAVERTQQRKLEELLLAAAREGKTTELTALLNRPNPPDVNCSDQLGNTPLHCAAYRAHKQCALKLLRSGADPNLKNKNDQKPLDLAQGAEMKHILVGNKVIYKALKRYEGPLWKSSRFFGWRLFWVVLEHGVLSWYRKQPDAVHNIYRQGCKHLTQAVCTVKSTDSCLFFIKCFDDTIHGFRVPKNSLQQSREDWLEAIEEHSAYSTHYCSQDQLTDEEEEDTVSAADLKKSLEKAQSCQQRLDREISNFLKMIKECDMAKEMLPSFLQKVEVVSEASRETCVALTDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELEQSLVKGSPPASILSEDEFYDALSDSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSYWDRNYFNLPDIY
oxysterol-binding protein-related protein 1 isoform 3
Refseq ID NP_001229437
Protein GI 335353788
UniProt ID Q9BXW6
mRNA ID NM_001242508
Length 568
RefSeq Status REVIEWED
MIKECDMAKEMLPSFLQKVEVVSEASRETCVALTDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELEQSLVKGSPPASILSEDEFYDALSDSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSYWDRNYFNLPDIY

Gene Information

Entrez Gene ID
114876
Gene Name
oxysterol binding protein-like 1A
Gene Symbol
OSBPL1A
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0006869 IEA:UniProtKB-KW P lipid transport

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_75774 Adaptive Immune System
REACT_6900 Immune System
REACT_121399 MHC class II antigen presentation

Domain Information

InterPro Annotations

Accession Description
IPR000648 Oxysterol-binding protein
IPR018494 Oxysterol-binding protein, conserved site

UniProt Annotations

Entry Information

Gene Name
oxysterol binding protein-like 1A
Protein Entry
OSBL1_HUMAN
UniProt ID
Q9BXW6
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP006802 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
19718746 RefSeq NP_060500 437 oxysterol-binding protein-related protein 1 isoform 1
19718741 RefSeq NP_542164 950 oxysterol-binding protein-related protein 1 isoform 2
335353788 RefSeq NP_001229437 568 oxysterol-binding protein-related protein 1 isoform 3

Identical Sequences to LMP006802 proteins

Reference Database Accession Length Protein Name
GI:335353788 DBBJ BAH13569.1 568 unnamed protein product [Homo sapiens]
GI:19718746 EMBL CAD33386.1 437 unnamed protein product [Homo sapiens]
GI:19718746 GenBank AAH63420.1 437 Oxysterol binding protein-like 1A [Homo sapiens]
GI:19718746 GenBank AAH98384.1 437 Oxysterol binding protein-like 1A [Homo sapiens]
GI:19718741 GenBank EAX01182.1 950 oxysterol binding protein-like 1A, isoform CRA_c [Homo sapiens]
GI:19718746 GenBank EAX01183.1 437 oxysterol binding protein-like 1A, isoform CRA_d [Homo sapiens]
GI:19718741 GenBank ACA06034.1 950 oxysterol-binding protein-related protein 1 variant 1 [Homo sapiens]
GI:19718746 GenBank ACA06035.1 437 oxysterol-binding protein-related protein 1 variant 2 [Homo sapiens]
GI:19718741 GenBank AAI36453.1 950 Oxysterol binding protein-like 1A [Homo sapiens]
GI:19718746 GenBank AHD74699.1 437 Sequence 14716 from patent US 8586006
GI:19718741 GenBank AHD74700.1 950 Sequence 14717 from patent US 8586006
GI:19718741 SwissProt Q9BXW6.2 950 RecName: Full=Oxysterol-binding protein-related protein 1; Short=ORP-1; Short=OSBP-related protein 1 [Homo sapiens]

Related Sequences to LMP006802 proteins

Reference Database Accession Length Protein Name
GI:19718741 DBBJ BAF85584.1 950 unnamed protein product [Homo sapiens]
GI:19718741 GenBank AAL40663.1 950 oxysterol-binding protein-like protein OSBPL1B [Homo sapiens]
GI:19718746 GenBank EAX01182.1 950 oxysterol binding protein-like 1A, isoform CRA_c [Homo sapiens]
GI:335353788 GenBank EAX01182.1 950 oxysterol binding protein-like 1A, isoform CRA_c [Homo sapiens]
GI:19718746 GenBank ACA06034.1 950 oxysterol-binding protein-related protein 1 variant 1 [Homo sapiens]
GI:335353788 GenBank ACA06034.1 950 oxysterol-binding protein-related protein 1 variant 1 [Homo sapiens]
GI:19718741 GenBank AAI44118.1 950 Oxysterol binding protein-like 1A [Homo sapiens]
GI:19718746 GenBank AAI36453.1 950 Oxysterol binding protein-like 1A [Homo sapiens]
GI:335353788 GenBank AAI36453.1 950 Oxysterol binding protein-like 1A [Homo sapiens]
GI:19718741 GenBank JAA08892.1 950 oxysterol binding protein-like 1A [Pan troglodytes]
GI:19718741 GenBank JAA15038.1 950 oxysterol binding protein-like 1A [Pan troglodytes]
GI:19718741 GenBank JAA31020.1 950 oxysterol binding protein-like 1A [Pan troglodytes]
GI:335353788 GenBank AHD74700.1 950 Sequence 14717 from patent US 8586006
GI:19718746 GenBank AHD74700.1 950 Sequence 14717 from patent US 8586006
GI:335353788 RefSeq NP_542164.2 950 oxysterol-binding protein-related protein 1 isoform 2 [Homo sapiens]
GI:19718746 RefSeq NP_542164.2 950 oxysterol-binding protein-related protein 1 isoform 2 [Homo sapiens]
GI:19718746 SwissProt Q9BXW6.2 950 RecName: Full=Oxysterol-binding protein-related protein 1; Short=ORP-1; Short=OSBP-related protein 1 [Homo sapiens]
GI:335353788 SwissProt Q9BXW6.2 950 RecName: Full=Oxysterol-binding protein-related protein 1; Short=ORP-1; Short=OSBP-related protein 1 [Homo sapiens]