Gene/Proteome Database (LMPD)
Proteins
| lysophospholipid acyltransferase 5 | |
|---|---|
| Refseq ID | NP_005759 |
| Protein GI | 42542394 |
| UniProt ID | Q6P1A2 |
| mRNA ID | NM_005768 |
| Length | 487 |
| RefSeq Status | VALIDATED |
| MASSAEGDEGTVVALAGVLQSGFQELSLNKLATSLGASEQALRLIISIFLGYPFALFYRHYLFYKETYLIHLFHTFTGLSIAYFNFGNQLYHSLLCIVLQFLILRLMGRTITAVLTTFCFQMAYLLAGYYYTATGNYDIKWTMPHCVLTLKLIGLAVDYFDGGKDQNSLSSEQQKYAIRGVPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVQGELIDIPGKIPNSIIPALKRLSLGLFYLVGYTLLSPHITEDYLLTEDYDNHPFWFRCMYMLIWGKFVLYKYVTCWLVTEGVCILTGLGFNGFEEKGKAKWDACANMKVWLFETNPRFTGTIASFNINTNAWVARYIFKRLKFLGNKELSQGLSLLFLALWHGLHSGYLVCFQMEFLIVIVERQAARLIQESPTLSKLAAITVLQPFYYLVQQTIHWLFMGYSMTAFCLFTWDKWLKVYKSIYFLGHIFFLSLLFILPYIHKAMVPRKEKLKKME | |
Gene Information
Entrez Gene ID
Gene Name
lysophosphatidylcholine acyltransferase 3
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005789 | TAS:Reactome | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0016020 | IDA:UniProtKB | C | membrane |
| GO:0047184 | IMP:MGI | F | 1-acylglycerophosphocholine O-acyltransferase activity |
| GO:0046474 | TAS:Reactome | P | glycerophospholipid biosynthetic process |
| GO:0036151 | TAS:Reactome | P | phosphatidylcholine acyl-chain remodeling |
| GO:0036152 | TAS:Reactome | P | phosphatidylethanolamine acyl-chain remodeling |
| GO:0036150 | TAS:Reactome | P | phosphatidylserine acyl-chain remodeling |
| GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
| GO:0097006 | IEA:Ensembl | P | regulation of plasma lipoprotein particle levels |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00564 | Glycerophospholipid metabolism |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_120829 | Acyl chain remodelling of PC |
| REACT_121369 | Acyl chain remodelling of PE |
| REACT_121384 | Acyl chain remodelling of PS |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR004299 | Membrane bound O-acyl transferase, MBOAT |
UniProt Annotations
Entry Information
Gene Name
lysophosphatidylcholine acyltransferase 3
Protein Entry
Q6P1A2_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P1A2-1; Sequence=Displayed; Name=2; IsoId=Q6P1A2-2; Sequence=VSP_053680; Note=No experimental confirmation available.; |
| Biophysicochemical Properties | Kinetic parameters: KM=41.29 uM for palmitoyl-CoA ; KM=36.65 uM for stearoyl-CoA ; KM=72.68 uM for oleoyl-CoA ; KM=201.4 uM for linoleoyl-CoA ; KM=71.56 uM for arachidonoyl-CoA ; KM=72.19 uM for 1-palmitoyl-lysophosphatidylcholine ; Vmax=1782 nmol/min/mg enzyme with palmitoyl-CoA and 1-palmitoyl- lysophosphatidylcholine as substrates ; Vmax=996 nmol/min/mg enzyme with stearoyl-CoA and 1-palmitoyl- lysophosphatidylcholine as substrates ; Vmax=4698 nmol/min/mg enzyme with oleoyl-CoA and 1-palmitoyl- lysophosphatidylcholine as substrates ; Vmax=18148 nmol/min/mg enzyme with linoleoyl-CoA and 1- palmitoyl-lysophosphatidylcholine as substrates ; Vmax=6247 nmol/min/mg enzyme with arachidonoyl-CoA and 1- palmitoyl-lysophosphatidylcholine as substrates ; |
| Catalytic Activity | Acyl-CoA + 1-acyl-sn-glycero-3- phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3- phosphatidylserine. |
| Catalytic Activity | Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine. |
| Domain | The di-lysine motif confers endoplasmic reticulum localization. |
| Enzyme Regulation | Activity is inhibited by thimerosal. |
| Function | Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3- phosphocholine or PC) (LPCAT activity). Catalyzes also the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero- 3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn- glycero-3-phospho-L-serine or PS) (LPSAT activity). Has also weak lysophosphatidylethanolamine acyltransferase activity (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Seems to be the major enzyme contributing to LPCAT activity in the liver. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO |
| Pathway | Lipid metabolism; phospholipid metabolism. |
| Sequence Caution | Sequence=AAB51326.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=AAC51640.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAG37917.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; |
| Similarity | Belongs to the membrane-bound acyltransferase family. |
| Subcellular Location | Endoplasmic reticulum membrane ; Multi-pass membrane protein . |
| Tissue Specificity | Highly expressed in liver, pancreas and adipose tissue. Very low expression in skeletal muscle and heart. Detected in neutrophils. {ECO |
Identical and Related Proteins
Unique RefSeq proteins for LMP006804 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 42542394 | RefSeq | NP_005759 | 487 | lysophospholipid acyltransferase 5 |
Identical Sequences to LMP006804 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:42542394 | DBBJ | BAI45478.1 | 487 | lysophosphatidylcholine acyltransferase 3, partial [synthetic construct] |
| GI:42542394 | GenBank | EAW88693.1 | 487 | O-acyltransferase (membrane bound) domain containing 5, isoform CRA_c [Homo sapiens] |
| GI:42542394 | GenBank | ACQ18666.1 | 487 | Sequence 580 from patent US 7510850 |
| GI:42542394 | GenBank | ADM04747.1 | 487 | Sequence 85 from patent US 7732155 |
| GI:42542394 | GenBank | AGM70885.1 | 487 | Sequence 85 from patent US 8383886 |
| GI:42542394 | GenBank | AHD73225.1 | 487 | Sequence 10293 from patent US 8586006 |
Related Sequences to LMP006804 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:42542394 | GenBank | JAA07049.1 | 487 | lysophosphatidylcholine acyltransferase 3 [Pan troglodytes] |
| GI:42542394 | GenBank | JAA07050.1 | 487 | lysophosphatidylcholine acyltransferase 3 [Pan troglodytes] |
| GI:42542394 | GenBank | JAA07051.1 | 487 | lysophosphatidylcholine acyltransferase 3 [Pan troglodytes] |
| GI:42542394 | GenBank | JAA07052.1 | 487 | lysophosphatidylcholine acyltransferase 3 [Pan troglodytes] |
| GI:42542394 | GenBank | JAA07053.1 | 487 | lysophosphatidylcholine acyltransferase 3 [Pan troglodytes] |
| GI:42542394 | GenBank | JAA23753.1 | 487 | lysophosphatidylcholine acyltransferase 3 [Pan troglodytes] |