Gene/Proteome Database (LMPD)

LMPD ID
LMP006819
Gene ID
851726
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
alpha-ketoglutarate dehydrogenase KGD2
Gene Symbol
KGD2
Synonyms
-
Alternate Names
alpha-ketoglutarate dehydrogenase KGD2
Chromosome
IV
EC Number
2.3.1.61

Proteins

alpha-ketoglutarate dehydrogenase KGD2
Refseq ID NP_010432
Protein GI 398365855
UniProt ID P19262
mRNA ID NM_001180455
Length 463
RefSeq Status PROVISIONAL
MLSRATRTAAAKSLVKSKVARNVMAASFVKRHASTSLFKQANKVESLGSIYLSGKKISVAANPFSITSNRFKSTSIEVPPMAESLTEGSLKEYTKNVGDFIKEDELLATIETDKIDIEVNSPVSGTVTKLNFKPEDTVTVGEELAQVEPGEAPAEGSGESKPEPTEQAEPSQGVAARENSSEETASKKEAAPKKEAAPKKEVTEPKKADQPKKTVSKAQEPPVASNSFTPFPRTETRVKMNRMRLRIAERLKESQNTAASLTTFNEVDMSALMEMRKLYKDEIIKKTGTKFGFMGLFSKACTLAAKDIPAVNGAIEGDQIVYRDYTDISVAVATPKGLVTPVVRNAESLSVLDIENEIVRLSHKARDGKLTLEDMTGGTFTISNGGVFGSLYGTPIINSPQTAVLGLHGVKERPVTVNGQIVSRPMMYLALTYDHRLLDGREAVTFLKTVKELIEDPRKMLLW

Gene Information

Entrez Gene ID
851726
Gene Name
alpha-ketoglutarate dehydrogenase KGD2
Gene Symbol
KGD2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042645 IDA:SGD C mitochondrial nucleoid
GO:0009353 IDA:SGD C mitochondrial oxoglutarate dehydrogenase complex
GO:0004149 ISA:SGD F dihydrolipoyllysine-residue succinyltransferase activity
GO:0006103 IMP:SGD P 2-oxoglutarate metabolic process
GO:0033512 IEA:UniProtKB-UniPathway P L-lysine catabolic process to acetyl-CoA via saccharopine
GO:0000002 IGI:SGD P mitochondrial genome maintenance
GO:0006099 IC:SGD P tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID Description
sce01200 Carbon metabolism
sce00020 Citrate cycle (TCA cycle)
sce_M00009 Citrate cycle (TCA cycle, Krebs cycle)

BIOCYC Pathway Links

BIOCYC Pathway ID Description
TCA-EUK-PWY-YEAST TCA cycle, aerobic respiration

Domain Information

InterPro Annotations

Accession Description
IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
IPR000089 Biotin/lipoyl attachment
IPR023213 Chloramphenicol acetyltransferase-like domain
IPR006255 Dihydrolipoamide succinyltransferase
IPR011053 Single hybrid motif

UniProt Annotations

Entry Information

Gene Name
alpha-ketoglutarate dehydrogenase KGD2
Protein Entry
ODO2_YEAST
UniProt ID
P19262
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Succinyl-CoA + enzyme N(6)- (dihydrolipoyl)lysine = CoA + enzyme N(6)-(S- succinyldihydrolipoyl)lysine.
Cofactor Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Note=Binds 1 lipoyl cofactor covalently.;
Function The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
Induction Transcriptionally regulated by glucose and activated by the HAP2 and HAP3 proteins.
Interaction P19955:YMR31; NbExp=3; IntAct=EBI-12464, EBI-16295;
Miscellaneous Present with 7970 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.
Similarity Belongs to the 2-oxoacid dehydrogenase family. {ECO:0000305}.
Similarity Contains 1 lipoyl-binding domain. {ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000305}.
Subcellular Location Mitochondrion.

Identical and Related Proteins

Unique RefSeq proteins for LMP006819 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
398365855 RefSeq NP_010432 463 alpha-ketoglutarate dehydrogenase KGD2

Identical Sequences to LMP006819 proteins

Reference Database Accession Length Protein Name
GI:398365855 GenBank AGO72487.1 463 Sequence 165 from patent US 8470972
GI:398365855 GenBank AGU32478.1 463 Sequence 165 from patent US 8507277
GI:398365855 GenBank AGX48382.1 463 Sequence 165 from patent US 8541550
GI:398365855 GenBank EWG87191.1 463 Kgd2p [Saccharomyces cerevisiae R008]
GI:398365855 GenBank EWG97109.1 463 Kgd2p [Saccharomyces cerevisiae R103]
GI:398365855 gnl McCuskerlabDuke 463 Kgd2p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP006819 proteins

Reference Database Accession Length Protein Name
GI:398365855 GenBank AAA34720.1 475 dihydrolipoyl transsuccinylase [Saccharomyces cerevisiae]
GI:398365855 GenBank EDN60488.1 463 alpha-ketoglutarate dehydrogenase complex dihydrolipoyl transsuccinylase component [Saccharomyces cerevisiae YJM789]
GI:398365855 GenBank EEU09325.1 463 Kgd2p [Saccharomyces cerevisiae JAY291]
GI:398365855 GenBank EHN03144.1 457 Kgd2p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:398365855 GenBank EJS42401.1 462 kgd2p [Saccharomyces arboricola H-6]
GI:398365855 GenBank EJT42202.1 457 KGD2-like protein [Saccharomyces kudriavzevii IFO 1802]