Gene/Proteome Database (LMPD)
Proteins
| phosphatidylinositol phospholipase C | |
|---|---|
| Refseq ID | NP_015055 |
| Protein GI | 6324987 |
| UniProt ID | P32383 |
| mRNA ID | NM_001184082 |
| Length | 869 |
| RefSeq Status | PROVISIONAL |
| MTESAIDDQRFNLTKELQRHSCRDQGKITQKDDALDFISYSSFQSSFNTDQKSANNGSTVRRSIRSIFRRAAELPRVHMGPLTYSHGINELVNKKLRKDCDLSTLCRVLQRGIRMIRMTRRRRKFYEFKLINNNGQIIWKDGSKYLELDSVKDIRIGDTASTYQEEVDPKRLRSDSKLWIAIIYKVSNKLKALHVVALNELDFNTFLSCICGLVKLRRELMESILLPDNSQFARIHWQITVSEKEEDEKKDTLSFADVKKLCDKFHIYVSTGQLLEFFQLADINHNGLLNYFEFEKFIKILKNRKEVNMIWSKFTKPPHSHLSFENFFQFLITEQHEQVDRQTAWSYFIKYREPTQLTMGQDGFTKFLKEQPYLVEVKEELYSKPLNHYFIASSHNTYLLGKQIAETPSVEGYIQVLQQGCRCVEIDIWDGENGPVVCHGFLTSAIPLKTVIRVIKKYAFITSPYPLIISLEINCNKDNQKLASLIMREVLAEQLYFVGTRTDKLPSPRELKHKILLKSKKTSEATRGLSVNEPFPSSFSSSYESANEQELRMKDDSTNSSSATNSSSMQRIKRIGLKKHADIINDVSNISGIHGIKFRNFSLPESKTIAHCFSLNERKVEYMIKDKHLKLSLDKHNRRYLMRVYPHVLRYKSSNFNPIPFWKAGVQMVATNWQTNDIGQQLNLAMFQILDHQPDGSFKSGYVLKPKKLLPVVTKAKMIPLIYEHFENGSDPVTVKIRILSTQLLPRLNDTSPSRNNTNSFVKVEFHTDDEPTMPISIDKGTRISATEASTKSSQGNGFNPIWDAEVSITLKDTDLTFIKFMVISEETQIASVCLKLNYLRMGYRHIPLFNMEGEQYIFCTLFIHTQIL | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol phospholipase C
Gene Symbol
Species
Saccharomyces cerevisiae S288c
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0000775 | IDA:SGD | C | chromosome, centromeric region |
| GO:0000778 | IPI:SGD | C | condensed nuclear chromosome kinetochore |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0004435 | IDA:SGD | F | phosphatidylinositol phospholipase C activity |
| GO:0004871 | IEA:UniProtKB-KW | F | signal transducer activity |
| GO:0032958 | IMP:SGD | P | inositol phosphate biosynthetic process |
| GO:0035556 | IEA:InterPro | P | intracellular signal transduction |
| GO:0009395 | IDA:SGD | P | phospholipid catabolic process |
| GO:0034501 | IMP:SGD | P | protein localization to kinetochore |
| GO:0001402 | IGI:SGD | P | signal transduction involved in filamentous growth |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| sce00562 | Inositol phosphate metabolism |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
| PWY3O-402 | inositol phosphate biosynthesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5618629 | Synthesis of IP3 and IP4 in the cytosol |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR000008 | C2 domain |
| IPR018247 | EF-Hand 1, calcium-binding site |
| IPR002048 | EF-hand domain |
| IPR011992 | EF-hand domain pair |
| IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
| IPR001192 | Phosphoinositide phospholipase C family |
| IPR000909 | Phospholipase C, phosphatidylinositol-specific , X domain |
| IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
| IPR011993 | Pleckstrin homology-like domain |
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol phospholipase C
Protein Entry
PLC1_YEAST
UniProt ID
Species
Yeast (S288c)
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Required for cell growth, osmoresistance and expression of GPD1. {ECO:0000269|PubMed:12073033}. |
| Interaction | Q06132:SGD1; NbExp=3; IntAct=EBI-13485, EBI-34377; |
| Similarity | Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}. |
| Similarity | Contains 1 EF-hand domain. {ECO:0000255|PROSITE- ProRule:PRU00448}. |
| Similarity | Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}. |
| Similarity | Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}. |
| Subunit | Interacts with SGD1. {ECO:0000269|PubMed:12073033}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006820 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6324987 | RefSeq | NP_015055 | 869 | phosphatidylinositol phospholipase C |
Identical Sequences to LMP006820 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6324987 | EMBL | CBF62879.1 | 869 | unnamed protein product [Saccharomyces cerevisiae] |
| GI:6324987 | EMBL | CBU87755.1 | 869 | unnamed protein product [Saccharomyces cerevisiae] |
| GI:6324987 | EMBL | CBU96702.1 | 869 | unnamed protein product [Saccharomyces cerevisiae] |
| GI:6324987 | GenBank | AGX54690.1 | 869 | Sequence 9736 from patent US 8541208 |
| GI:6324987 | GenBank | AGX64130.1 | 869 | Sequence 28370 from patent US 8541208 |
| GI:6324987 | Third Party Genbank | DAA11168.1 | 869 | TPA: phosphatidylinositol phospholipase C [Saccharomyces cerevisiae S288c] |
Related Sequences to LMP006820 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6324987 | GenBank | AAA99927.1 | 869 | phospholipase C [Saccharomyces cerevisiae] |
| GI:6324987 | GenBank | EWG85446.1 | 869 | Plc1p [Saccharomyces cerevisiae R008] |
| GI:6324987 | GenBank | EWG88316.1 | 869 | Plc1p [Saccharomyces cerevisiae P301] |
| GI:6324987 | GenBank | EWG93138.1 | 869 | Plc1p [Saccharomyces cerevisiae R103] |
| GI:6324987 | GenBank | EWH15647.1 | 869 | Plc1p [Saccharomyces cerevisiae P283] |
| GI:6324987 | gnl | McCuskerlabDuke | 869 | Plc1p [Saccharomyces cerevisiae YJM993] |