LIPID MAPS

LMPD ID

LMP006833

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

ATP-binding cassette long-chain fatty acid transporter PXA2

Gene Symbol

Synonyms

PAT1

Chromosome

XI

ATP-binding cassette long-chain fatty acid transporter PXA2
Refseq ID	NP_012733
Protein GI	6322660
UniProt ID	P34230
mRNA ID	NM_001179754
Length	853
MISTASAFYQKHRVNLLRSSYIILLLATLYNSNSSSSNNKTDKKDSESTVLENKKIEEGKETAVDREEDESSKEELTIVSKHSTDSEDGAIIIDKESKTNHKGGERKGKVDFLFKLLLHDKKCLILFITQAILLNIRTLLSLRVATLDGQLVSTLVRAQYANFTKILLGKWMILGIPASFINSLISYTTKLCAVTINRKVSDFLLSKYLSNHHTFYSVASAESVSEIQDNLTKDIYTFSMNSSLLLNQLLKPMLDLILCSFKLLTSNTSVMGEGTLALGLIVYASNSLLKLIQPNFTRLTMASASLESWFRSLHSNLHSSNEEIALLRGQKRELENVDYSFYRLVLFLNREIKARAIYDVATAFVIKYTWGAAGLVLCSIPIFFKNKPSEDTLQLKEPGNDMTADFITNRRLLVTASSSIGRFVELKRNIQQLRGIRLRLNKFNDLLDANKGDDEKEPRDERCIVEYDDSRIKFENIPLITPANQVLVPELSFDLKHGNHLLIIGPNGCGKSSLFRILGGLWPIRATPNKNHQSKLIMPRRTVDRDCAIFYLPQRPYMGNRSTFREQIIYPDSIEQFKERYHNDYDLGDADLIKILQLLDLEDLVTENMSLLLAQRTSKNDSQQLSTEDNQSPCAIKVRDAFSIVRNWSEELTIGVQQRLAMARMYYHKPKFAVLDECTSAVAPEMEQRMYENAQNFGISLISVCHRTSLWHFHNYLLKFDGKGGYQFGPFNPKERLCNEEKLLELNAILDQQVPLWERKLKDLTIAKESNIIRKSETNLNLFEKIEDPKTSKSNALFNANKGQRITSPTGQETSKRLPLFSQPSSSASSNLLRNNKSLNKKVKTKKEEGKER

Entrez Gene ID

Gene Name

ATP-binding cassette long-chain fatty acid transporter PXA2

Gene Symbol

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005779	IDA:SGD	C	integral component of peroxisomal membrane
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0042626	IDA:SGD	F	ATPase activity, coupled to transmembrane movement of substances
GO:0005325	IGI:UniProtKB	F	peroxisomal fatty-acyl-CoA transporter activity
GO:0006635	IGI:UniProtKB	P	fatty acid beta-oxidation
GO:1902001	IDA:SGD	P	fatty acid transmembrane transport
GO:0015916	IGI:UniProtKB	P	fatty-acyl-CoA transport
GO:0042758	IMP:UniProtKB	P	long-chain fatty acid catabolic process
GO:0015910	IGI:UniProtKB	P	peroxisomal long-chain fatty acid import
GO:0042760	IMP:UniProtKB	P	very long-chain fatty acid catabolic process

REACTOME Pathway ID	Description
5618451	ABC-family proteins mediated transport
5618450	ABCA transporters in lipid homeostasis
5618483	Beta-oxidation of very long chain fatty acids
5618630	Linoleic acid (LA) metabolism
5618023	Metabolism
5618091	Metabolism of lipids and lipoproteins
5618473	Peroxisomal lipid metabolism
5618037	Transmembrane transport of small molecules
5618631	alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
5618632	alpha-linolenic acid (ALA) metabolism

Accession	Description
IPR003593	AAA+ ATPase domain
IPR011527	ABC transporter type 1, transmembrane domain
IPR010509	ABC_Peroxi_TM
IPR003439	ABC_transporter-like
IPR027417	P-loop containing nucleoside triphosphate hydrolase
IPR005283	Peroxysomal long chain fatty acyl transporter

Gene Name

ATP-binding cassette long-chain fatty acid transporter PXA2

Protein Entry

PXA2_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Function	Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix
Function	Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix. {ECO:0000269\|PubMed:8670886}.
Interaction	P41909:PXA1; NbExp=2; IntAct=EBI-2464632, EBI-14344;
Similarity	Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily
Similarity	Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. {ECO:0000305}.
Similarity	Contains 1 ABC transmembrane type-1 domain
Similarity	Contains 1 ABC transmembrane type-1 domain. {ECO:0000255\|PROSITE-ProRule:PRU00441}.
Similarity	Contains 1 ABC transporter domain
Similarity	Contains 1 ABC transporter domain. {ECO:0000255\|PROSITE-ProRule:PRU00434}.
Subcellular Location	Peroxisome membrane; Multi-pass membrane protein.
Subunit	Forms a heterodimer with PXA1.