LIPID MAPS

LMPD ID

LMP006841

Gene ID

854076

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Avo1p

Gene Symbol

AVO1

Synonyms

-

Chromosome

XV

Avo1p
Refseq ID	NP_014563
Protein GI	6324494
UniProt ID	Q08236
mRNA ID	NM_001183332
Length	1176
MDTVTVLNELRAQFLRVCPEKDQMKRIIKPYIPVDEFNTEQCLDSSIRELYMNSDGVSLLPELESPPVSKDFMENYASLGKMRIMRENEGQKGKANQNLIGAEKTERDEEETRNLQDKSAKNTLIVEENGTLRYNPLNSSASNSLLNDDDHTSGKHHKTSSKEDSYLNSSMEMQKKSSKRSSLPFVRIFKSRRDHSNTSGNKNVMNTTNTRAKSSTLHPPGARHNKKGSKFDMNFDFDENLEEEDDDDDDDEEGDDIHSQFFQLDDDFDAKGSGASPAHKGINGMSNNKNNTYTNNRNSISILDDRESSNGNIGSASRLKSHFPTSQKGKIFLTDNKNDGQKSDSLNANKGIHGDGSSASGNGSVSRDGLTETESNNISDMESYINEKDLDDLNFDTVTSNINKTVSDLGGHESTNDGTAVMNRDSKDSRSNSNEFNAQNRDRITPGSSYGKSLLGSEYSEERYSNNDSSTMESGEMSLDSDMQTNTIPSHSIPMSMQKYGIYHGDDDSTLNNVFDKAVLTMNSSRHPKERRDTVISGKEPTSLTSSNRKFSVSSNLTSTRSPLLRGHGRTSSTASSEHMKAPKVSDSVLHRARKSTLTLKQDHSQPSVPSSVHKSSKEGNILIEKTTDYLVSKPKASQLSNMFNKKKKRTNTNSVDVLEYFSFVCGDKVPNYESMGLEIYIQASKKYKRNSFTTKVRKSSTIFEVIGFALFLYSTEKKPDNFEEDGLTVEDISNPNNFSLKIVDEDGEPFEDNFGKLDRKSTIQSISDSEVVLCKVDDAEKSQNEIETPLPFETGGGLMDASTLDANSSHDTTDGTINQLSFYKPIIGNEDDIDKTNGSKIIDVTVYLYPNVNPKFNYTTISVLVTSHINDILVKYCKMKNMDPNEYALKVLGKNYILDLNDTVLRLDGINKVELISKKDARELHLEKMKPDLKKPVLPTIQSNDLTPLTLEPLNSYLKADAGGAVAAIPENTKVTSKAKKISTKYKLGLAKQHSSSSVASGSVSTAGGLANGNGFFKNKNSSKSSLHGTLQFHNINRSQSTMEHTPDTPNGVGDNFQDLFTGAYHKYKVWRRQQMSFINKHERTLAIDGDYIYIVPPEGRIHWHDNVKTKSLHISQVVLVKKSKRVPEHFKIFVRREGQDDIKRYYFEAVSGQECTEIVTRLQNLLSAYRMNHK

Entrez Gene ID

854076

Gene Name

Avo1p

Gene Symbol

AVO1

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0031932	IPI:SGD	C	TORC2 complex
GO:0005737	IPI:SGD	C	cytoplasm
GO:0005886	IDA:SGD	C	plasma membrane
GO:0005773	IEA:UniProtKB-KW	C	vacuole
GO:0017016	ISS:SGD	F	Ras GTPase binding
GO:0005546	IDA:SGD	F	phosphatidylinositol-4,5-bisphosphate binding
GO:0031929	IC:SGD	P	TOR signaling
GO:0030950	IMP:SGD	P	establishment or maintenance of actin cytoskeleton polarity
GO:0031505	IPI:SGD	P	fungal-type cell wall organization
GO:0046580	ISS:SGD	P	negative regulation of Ras protein signal transduction
GO:0001558	IPI:SGD	P	regulation of cell growth

InterPro Annotations

Accession	Description
IPR008828	SIN1

Entry Information

Gene Name

Avo1p

Protein Entry

AVO1_YEAST

UniProt ID

Q08236

Species

Yeast (S288c)

Comments

Comment Type	Description
Function	Component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway.
Interaction	P41318:LST8; NbExp=2; IntAct=EBI-29284, EBI-28598; P32600:TOR2; NbExp=4; IntAct=EBI-29284, EBI-19385;
Miscellaneous	Present with 704 molecules/cell in log phase SD medium
Miscellaneous	Present with 704 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Ptm	Autophosphorylated by TORC2. {ECO:0000269\|PubMed:16002396, ECO:0000269\|PubMed:17330950, ECO:0000269\|PubMed:19779198}.
Similarity	Belongs to the SIN1 family
Similarity	Belongs to the SIN1 family. {ECO:0000305}.
Subcellular Location	Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Vacuole membrane ; Peripheral membrane protein ; Cytoplasmic side .
Subcellular Location	Cell membrane {ECO:0000269\|PubMed:12631735}; Peripheral membrane protein {ECO:0000269\|PubMed:12631735}; Cytoplasmic side {ECO:0000269\|PubMed:12631735}. Vacuole membrane {ECO:0000269\|PubMed:12631735}; Peripheral membrane protein {ECO:0000269\|PubMed:12631735}; Cytoplasmic side {ECO:0000269\|PubMed:12631735}.
Subunit	The target of rapamycin complex 2 (TORC2) is composed of at least AVO1, AVO2, BIT61, LST8, TOR2 and TSC11. TORC2 likely forms a homodimer. Contrary to TORC1, TORC2 does not bind to and is not sensitive to FKBP-rapamycin. AVO1 is required for TORC2 integrity by tethering AVO2 and TSC11 to the complex. {ECO:0000269\|PubMed:12408816, ECO:0000269\|PubMed:12631735, ECO:0000269\|PubMed:16002396}.