LIPID MAPS

LMPD ID

LMP006848

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Ist2p

Gene Symbol

IST2

Synonyms

-

Chromosome

II

Ist2p
Refseq ID	NP_009643
Protein GI	27808701
UniProt ID	P38250
mRNA ID	NM_001178434
Length	946
MSQTITSLDPNCVIVFNKTSSANEKSLNVEFKRLNIHSIIEPGHDLQTSYAFIRIHQDNAKPLFSFLQNLDFIESIIPYHDTELSDDLHKLISISKSKILEAPKQYELYNLSNLTNNPKQSLYFAFLQNYIKWLIPFSFFGLSIRFLSNFTYEFNSTYSLFAILWTLSFTAFWLYKYEPFWSDRLSKYSSFSTIEFLQDKQKAQKKASSVIMLKKCCFIPVALLFGAILLSFQLYCFALEIFIKQIYNGPMISILSFLPTILICTFTPVLTVIYNKYFVEPMTKWENHSSVVNAKKSKEAKNFVIIFLSSYVPLLITLFLYLPMGHLLTAEIRTKVFNAFSILARLPTHDSDFIIDTKRYEDQFFYFIVINQLIQFSMENFVPSLVSIAQQKINGPNPNFVKAESEIGKAQLSSSDMKIWSKVKSYQTDPWGATFDLDANFKKLLLQFGYLVMFSTIWPLAPFICLIVNLIVYQVDLRKAVLYSKPEYFPFPIYDKPSSVSNTQKLTVGLWNSVLVMFSILGCVITATLTYMYQSCNIPGVGAHTSIHTNKAWYLANPINHSWINIVLYAVFIEHVSVAIFFLFSSILKSSHDDVANGIVPKHVVNVQNPPKQEVFEKIPSPEFNSNNEKELVQRKGSANEKLHQELGEKQPASSANGYEAHAATHANNDPSSLSSASSPSLSSSSSSSKTGVVKAVDNDTAGSAGKKPLATESTEKRNSLVKVPTVGSYGVAGATLPETIPTSKNYYLRFDEDGKSIRDAKSSAESSNATNNNTLGTESKLLPDGDAVDALSRKIDQIPKIAVTGGENNENTQAKDDAATKTPLIKDANIKPVVNAAVNDNQSKVSVATEQTKKTEVSTKNGPSRSISTKETKDSARPSNNNTTTTTTTDATQPHHHHHHHRHRDAGVKNVTNNSKTTESSSSSSAAKEKPKHKKGLLHKLKKKL

Entrez Gene ID

Gene Name

Ist2p

Gene Symbol

IST2

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0033101	IDA:SGD	C	cellular bud membrane
GO:0032541	IDA:SGD	C	cortical endoplasmic reticulum
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0005886	IDA:SGD	C	plasma membrane
GO:0008289	IDA:SGD	F	lipid binding
GO:0090158	IGI:SGD	P	endoplasmic reticulum membrane organization
GO:0072659	IMP:SGD	P	protein localization to plasma membrane
GO:0060304	IGI:SGD	P	regulation of phosphatidylinositol dephosphorylation

REACTOME Pathway ID	Description
5618495	Ion channel transport
5618662	Stimuli-sensing channels
5618037	Transmembrane transport of small molecules

Accession	Description
IPR007632	Anoctamin

Gene Name

Ist2p

Protein Entry

IST2_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Function	May be involved in ion homeostasis together with BTN1 or BTN2
Function	May be involved in ion homeostasis together with BTN1 or BTN2. {ECO:0000269\|PubMed:15701790}.
Interaction	P53286:BTN2; NbExp=2; IntAct=EBI-21520, EBI-3796;
Subcellular Location	Cell membrane {ECO:0000269\|PubMed:11030653, ECO:0000269\|PubMed:15701790}; Multi-pass membrane protein {ECO:0000269\|PubMed:11030653, ECO:0000269\|PubMed:15701790}. Note=Correct localization requires BTN2. Localizes to the mother cell in small budded cells and to the bud in medium and large budded cells. Transported to the bud tip by an actomyosin based process. Compartmentalization maintained by a septin mediated membrane diffusion barrier at the mother-bud neck.
Subcellular Location	Cell membrane {ECO:0000269\|PubMed:11030653, ECO:0000269\|PubMed:15701790}; Multi-pass membrane protein . Note=Correct localization requires BTN2. Localizes to the mother cell in small budded cells and to the bud in medium and large budded cells. Transported to the bud tip by an actomyosin based process. Compartmentalization maintained by a septin mediated membrane diffusion barrier at the mother-bud neck.
Subunit	Interacts with BTN2
Subunit	Interacts with BTN2. {ECO:0000269\|PubMed:15701790}.