Gene/Proteome Database (LMPD)

LMPD ID
LMP006851
Gene ID
856101
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Ncr1p
Gene Symbol
NCR1
Synonyms
-
Alternate Names
Ncr1p
Chromosome
XVI

Proteins

Ncr1p
Refseq ID NP_015319
Protein GI 6325251
UniProt ID Q12200
mRNA ID NM_001183820
Length 1170
RefSeq Status PROVISIONAL
MNVLWIIALVGQLMRLVQGTATCAMYGNCGKKSVFGNELPCPVPRSFEPPVLSDETSKLLVEVCGEEWKEVRYACCTKDQVVALRDNLQKAQPLISSCPACLKNFNNLFCHFTCAADQGRFVNITKVEKSKEDKDIVAELDVFMNSSWASEFYDSCKNIKFSATNGYAMDLIGGGAKNYSQFLKFLGDAKPMLGGSPFQINYKYDLANEEKEWQEFNDEVYACDDAQYKCACSDCQESCPHLKPLKDGVCKVGPLPCFSLSVLIFYTICALFAFMWYYLCKRKKNGAMIVDDDIVPESGSLDESETNVFESFNNETNFFNGKLANLFTKVGQFSVENPYKILITTVFSIFVFSFIIFQYATLETDPINLWVSKNSEKFKEKEYFDDNFGPFYRTEQIFVVNETGPVLSYETLHWWFDVENFITEELQSSENIGYQDLCFRPTEDSTCVIESFTQYFQGALPNKDSWKRELQECGKFPVNCLPTFQQPLKTNLLFSDDDILNAHAFVVTLLLTNHTQSANRWEERLEEYLLDLKVPEGLRISFNTEISLEKELNNNNDISTVAISYLMMFLYATWALRRKDGKTRLLLGISGLLIVLASIVCAAGFLTLFGLKSTLIIAEVIPFLILAIGIDNIFLITHEYDRNCEQKPEYSIDQKIISAIGRMSPSILMSLLCQTGCFLIAAFVTMPAVHNFAIYSTVSVIFNGVLQLTAYVSILSLYEKRSNYKQITGNEETKESFLKTFYFKMLTQKRLIIIIFSAWFFTSLVFLPEIQFGLDQTLAVPQDSYLVDYFKDVYSFLNVGPPVYMVVKNLDLTKRQNQQKICGKFTTCERDSLANVLEQERHRSTITEPLANWLDDYFMFLNPQNDQCCRLKKGTDEVCPPSFPSRRCETCFQQGSWNYNMSGFPEGKDFMEYLSIWINAPSDPCPLGGRAPYSTALVYNETSVSASVFRTAHHPLRSQKDFIQAYSDGVRISSSFPELDMFAYSPFYIFFVQYQTLGPLTLKLIGSAIILIFFISSVFLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVEFCVHIVRSFTVVPSETKKDANSRVLYSLNTIGESVIKGITLTKFIGVCVLAFAQSKIFDVFYFRMWFTLIIVAALHALLFLPALLSLFGGESYRDDSIEAED

Gene Information

Entrez Gene ID
856101
Gene Name
Ncr1p
Gene Symbol
NCR1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000329 IDA:SGD C fungal-type vacuole membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0008158 IEA:InterPro F hedgehog receptor activity
GO:0046624 IMP:SGD F sphingolipid transporter activity
GO:0006665 IMP:SGD P sphingolipid metabolic process

REACTOME Pathway Links

REACTOME Pathway ID Description
5618294 Lipid digestion, mobilization, and transport
5618023 Metabolism
5618091 Metabolism of lipids and lipoproteins
5618449 Trafficking of dietary sterols

Domain Information

InterPro Annotations

Accession Description
IPR003392 Patched
IPR000731 Sterol-sensing domain

UniProt Annotations

Entry Information

Gene Name
Ncr1p
Protein Entry
NPC1_YEAST
UniProt ID
Q12200
Species
Yeast (S288c)

Comments

Comment Type Description
Function Involved in sphingolipid trafficking. May recycle sphingolipids between cellular membranous compartments. {ECO:0000269|PubMed:14970192, ECO:0000269|PubMed:16138904}.
Miscellaneous Present with 521 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the patched family. {ECO:0000305}.
Similarity Contains 1 SSD (sterol-sensing) domain. {ECO:0000255|PROSITE-ProRule:PRU00199}.
Subcellular Location Vacuole membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14970192, ECO:0000269|PubMed:15522102}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14970192, ECO:0000269|PubMed:15522102}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006851 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6325251 RefSeq NP_015319 1170 Ncr1p

Identical Sequences to LMP006851 proteins

Reference Database Accession Length Protein Name
GI:6325251 GenBank ABH83292.1 1170 Sequence 6 from patent US 7045675
GI:6325251 GenBank EDV11204.1 1170 transmembrane protein [Saccharomyces cerevisiae RM11-1a]
GI:6325251 GenBank EIW07108.1 1170 Ncr1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6325251 GenBank EWG92904.1 1170 Ncr1p [Saccharomyces cerevisiae R103]
GI:6325251 gnl McCuskerlabDuke 1170 Ncr1p [Saccharomyces cerevisiae YJM993]
GI:6325251 Third Party Genbank DAA11422.1 1170 TPA: Ncr1p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP006851 proteins

Reference Database Accession Length Protein Name
GI:6325251 DBBJ GAA26967.1 1170 K7_Ncr1p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6325251 EMBL CAY86951.1 1170 Ncr1p [Saccharomyces cerevisiae EC1118]
GI:6325251 GenBank EDN61132.1 1170 Niemann-Pick type C-related protein [Saccharomyces cerevisiae YJM789]
GI:6325251 GenBank EEU05326.1 1170 Ncr1p [Saccharomyces cerevisiae JAY291]
GI:6325251 GenBank EHN04018.1 1170 Ncr1p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6325251 GenBank EJS41304.1 1170 ncr1p [Saccharomyces arboricola H-6]