Gene/Proteome Database (LMPD)
Proteins
| inositol polyphosphate kinase VIP1 | |
|---|---|
| Refseq ID | NP_013514 |
| Protein GI | 6323442 |
| UniProt ID | Q06685 |
| mRNA ID | NM_001182298 |
| Length | 1146 |
| MSGIKKEPIESDEVPQQETKNNLPSAPSEMSPLFLNKNTQKAMQSIAPILEGFSPKTSASENMSLKLPPPGIQDDHSEENLTVHDTLQRTISTALGNGNNTNTVTTSGLKKADSESKSEADPEGLSNSNIVNDADNINSISKTGSPHLPQGTMDAEQTNMGTNSVPTSSASSRKSSTSHPKPRLPKVGKIGVCAMDAKVLSKPMRHILNRLIEHGEFETVIFGDKVILDERIENWPTCDFLISFFSSGFPLDKAIKYVKLRKPFIINDLIMQKILWDRRLCLQVLEAYNVPTPPRLEISRDGGPRANEELRAKLREHGVEVKPVEEPEWKMVDDDTLEVDGKTMTKPFVEKPVDGEDHNIYIYYHSKNGGGGRRLFRKVGNKSSEFDPTLVHPRTEGSYIYEQFMDTDNFEDVKAYTIGENFCHAETRKSPVVDGIVRRNTHGKEVRYITELSDEEKTIAGKVSKAFSQMICGFDLLRVSGKSYVIDVNGFSFVKDNKAYYDSCANILRSTFIEAKKKMDMEKKNLPIIREEKEQKWVFKGLAIIIRHADRTPKQKFKHSFTSPIFISLLKGHKEEVVIRNVNDLKIVLQALRIALDEKAGNPAKIKVLANALEKKLNFPGTKIQLKPVLNKENEVEKVQFILKWGGEPTHSAKYQATELGEQMRQDFDLLNKSILQNIKIFSSSERRVLHTAQYWTRALFGADELGSDEISIRKDLLDDSNAAKDLMDKVKKKLKPLLREGKEAPPQFAWPSKMPEPYLVIKRVVELMNYHKKIMDNNFAKKDVNSMQTRWCTSEDPSLFKERWDKLFKEFNNAEKVDPSKISELYDTMKYDALHNRQFLENIFDPGLPNEAIADELGSHSLVDRYPINVLAKNNFKIIDSHSMNNSGKNSSNSVGSLGWVLESGKTSTARNPKSSSQFDEPRFMQLRELYKLAKVLFDFICPKEYGISDAEKLDIGLLTSLPLAKQILNDIGDMKNRETPACVAYFTKESHIYTLLNIIYESGIPMRIARNALPELDYLSQITFELYESTDASGQKSHSIRLKMSPGCHTQDPLDVQLDDRHYISCIPKISLTKHLDMDYVQQKLRNKFTRVIMPPKFTPVNITSPNLSFQKRKTRRKSVSVEKLKRPASSGSSSSTSVNKTLD | |
Gene Information
Entrez Gene ID
Gene Name
inositol polyphosphate kinase VIP1
Gene Symbol
Species
Saccharomyces cerevisiae S288c
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IEA:UniProtKB-KW | C | cytoplasm |
| GO:0005856 | IEA:UniProtKB-KW | C | cytoskeleton |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0003993 | IEA:InterPro | F | acid phosphatase activity |
| GO:0033857 | IEA:UniProtKB-EC | F | diphosphoinositol-pentakisphosphate kinase activity |
| GO:0000829 | IDA:SGD | F | inositol heptakisphosphate kinase activity |
| GO:0052723 | IDA:SGD | F | inositol hexakisphosphate 1-kinase activity |
| GO:0052724 | IDA:SGD | F | inositol hexakisphosphate 3-kinase activity |
| GO:0000830 | IDA:SGD | F | inositol hexakisphosphate 4-kinase activity |
| GO:0000832 | IEA:UniProtKB-EC | F | inositol hexakisphosphate 5-kinase activity |
| GO:0000831 | IDA:SGD | F | inositol hexakisphosphate 6-kinase activity |
| GO:0032958 | IDA:SGD | P | inositol phosphate biosynthetic process |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY3O-402 | inositol phosphate biosynthesis |
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
inositol polyphosphate kinase VIP1
Protein Entry
VIP1_YEAST
UniProt ID
Species
Yeast (S288c)
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate |
| Catalytic Activity | ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate. {ECO:0000269|PubMed:17412958}. |
| Catalytic Activity | ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6- pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate |
| Catalytic Activity | ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6- pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate. {ECO:0000269|PubMed:17412958}. |
| Catalytic Activity | ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate |
| Catalytic Activity | ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate. {ECO:0000269|PubMed:17412958}. |
| Catalytic Activity | ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate |
| Catalytic Activity | ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate. {ECO:0000269|PubMed:17412958}. |
| Caution | Although related to histidine acid phosphatase proteins, it lacks the conserved active sites, suggesting that it has no phosphatase activity |
| Caution | Although related to histidine acid phosphatase proteins, it lacks the conserved active sites, suggesting that it has no phosphatase activity. {ECO:0000305}. |
| Function | Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP- InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2- InsP4 (By similarity). Required for maintaining cellular integrity, normal growth and interactions with the ARP complex. Acts as a regulator of the PHO80-PHO85 cyclin/cyclin-dependent kinase (CDK) complex, thereby regulating signaling of phosphate availability. Required for the function of the cortical actin cytoskeleton, possibly by participating in correct F-actin localization and ensuring polarized growth. {ECO:0000250, ECO:0000269|PubMed:10388810, ECO:0000269|PubMed:17412958, ECO:0000269|PubMed:17412959}. |
| Miscellaneous | Present with 8810 molecules/cell in log phase SD medium |
| Miscellaneous | Present with 8810 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity | Belongs to the histidine acid phosphatase family. VIP1 subfamily |
| Similarity | Belongs to the histidine acid phosphatase family. VIP1 subfamily. {ECO:0000305}. |
| Subcellular Location | Cytoplasm . Cytoplasm, cytoskeleton . |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:14562095}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14562095}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006852 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6323442 | RefSeq | NP_013514 | 1146 | inositol polyphosphate kinase VIP1 |
Identical Sequences to LMP006852 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|
Related Sequences to LMP006852 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|