Gene/Proteome Database (LMPD)

LMPD ID
LMP006860
Gene ID
854646
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
acetyl-CoA C-acyltransferase
Gene Symbol
POT1
Synonyms
FOX3; POX3
Alternate Names
acetyl-CoA C-acyltransferase
Chromosome
IX
EC Number
2.3.1.16

Proteins

acetyl-CoA C-acyltransferase
Refseq ID NP_012106
Protein GI 6322031
UniProt ID P27796
mRNA ID NM_001179508
Length 417
RefSeq Status PROVISIONAL
MSQRLQSIKDHLVESAMGKGESKRKNSLLEKRPEDVVIVAANRSAIGKGFKGAFKDVNTDYLLYNFLNEFIGRFPEPLRADLNLIEEVACGNVLNVGAGATEHRAACLASGIPYSTPFVALNRQCSSGLTAVNDIANKIKVGQIDIGLALGVESMTNNYKNVNPLGMISSEELQKNREAKKCLIPMGITNENVAANFKISRKDQDEFAANSYQKAYKAKNEGLFEDEILPIKLPDGSICQSDEGPRPNVTAESLSSIRPAFIKDRGTTTAGNASQVSDGVAGVLLARRSVANQLNLPVLGRYIDFQTVGVPPEIMGVGPAYAIPKVLEATGLQVQDIDIFEINEAFAAQALYCIHKLGIDLNKVNPRGGAIALGHPLGCTGARQVATILRELKKDQIGVVSMCIGTGMGAAAIFIKE

Gene Information

Entrez Gene ID
854646
Gene Name
acetyl-CoA C-acyltransferase
Gene Symbol
POT1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005758 IDA:SGD C mitochondrial intermembrane space
GO:0005782 IDA:SGD C peroxisomal matrix
GO:0005777 IDA:SGD C peroxisome
GO:0003988 IDA:SGD F acetyl-CoA C-acyltransferase activity
GO:0003729 IDA:SGD F mRNA binding
GO:0006635 IMP:SGD P fatty acid beta-oxidation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-7337 10-cis-heptadecenoyl-CoA degradation
PWY-7338 10-trans-heptadecenoyl-CoA degradation (reductase-dependent)
PWY-7340 9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent)
PWY-7288 fatty acid beta-oxidation (peroxisome)

Domain Information

InterPro Annotations

Accession Description
IPR002155 Thiolase
IPR020617 Thiolase, C-terminal
IPR020616 Thiolase, N-terminal
IPR020610 Thiolase, active site
IPR020615 Thiolase, acyl-enzyme intermediate active site
IPR020613 Thiolase, conserved site
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup

UniProt Annotations

Entry Information

Gene Name
acetyl-CoA C-acyltransferase
Protein Entry
THIK_YEAST
UniProt ID
P27796
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
Interaction P39108:PEX7; NbExp=3; IntAct=EBI-19236, EBI-13183;
Pathway Lipid metabolism; fatty acid metabolism.
Similarity Belongs to the thiolase family. {ECO:0000305}.
Subcellular Location Peroxisome.
Subunit Homodimer.

Identical and Related Proteins

Unique RefSeq proteins for LMP006860 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6322031 RefSeq NP_012106 417 acetyl-CoA C-acyltransferase

Identical Sequences to LMP006860 proteins

Reference Database Accession Length Protein Name
GI:6322031 GenBank EHN06561.1 417 Pot1p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6322031 GenBank EIW09918.1 417 Pot1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6322031 GenBank EWG90427.1 417 Pot1p [Saccharomyces cerevisiae P301]
GI:6322031 GenBank EWG95388.1 417 Pot1p [Saccharomyces cerevisiae R103]
GI:6322031 GenBank EWH16163.1 417 Pot1p [Saccharomyces cerevisiae P283]
GI:6322031 gnl McCuskerlabDuke 417 Pot1p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP006860 proteins

Reference Database Accession Length Protein Name
GI:6322031 GenBank EEU05467.1 417 Pot1p [Saccharomyces cerevisiae JAY291]
GI:6322031 GenBank EHN01976.1 417 Pot1p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6322031 GenBank EJS43329.1 417 pot1p [Saccharomyces arboricola H-6]
GI:6322031 GenBank EWG85249.1 417 Pot1p [Saccharomyces cerevisiae R008]
GI:6322031 PDB 1AFW 393 Chain A, The 1.8 Angstrom Crystal Structure Of The Dimeric Peroxisomal Thiolase Of Saccharomyces Cerevisiae
GI:6322031 PDB 1AFW 393 Chain B, The 1.8 Angstrom Crystal Structure Of The Dimeric Peroxisomal Thiolase Of Saccharomyces Cerevisiae