Gene/Proteome Database (LMPD)
Proteins
| C-8 sterol isomerase ERG2 | |
|---|---|
| Refseq ID | NP_013929 |
| Protein GI | 6323858 |
| UniProt ID | P32352 |
| mRNA ID | NM_001182709 |
| Length | 222 |
| RefSeq Status | PROVISIONAL |
| MKFFPLLLLIGVVGYIMNVLFTTWLPTNYMFDPKTLNEICNSVISKHNAAEGLSTEDLLQDVRDALASHYGDEYINRYVKEEWVFNNAGGAMGQMIILHASVSEYLILFGTAVGTEGHTGVHFADDYFTILHGTQIAALPYATEAEVYTPGMTHHLKKGYAKQYSMPGGSFALELAQGWIPCMLPFGFLDTFSSTLDLYTLYRTVYLTARDMGKNLLQNKKF | |
Gene Information
Entrez Gene ID
Gene Name
C-8 sterol isomerase ERG2
Gene Symbol
Species
Saccharomyces cerevisiae S288c
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IC:SGD | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0000247 | IMP:SGD | F | C-8 sterol isomerase activity |
| GO:0006696 | IMP:SGD | P | ergosterol biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| sce_M00102 | Ergocalciferol biosynthesis |
| sce00100 | Steroid biosynthesis |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6075 | ergosterol biosynthesis |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR006716 | ERG2/sigma1 receptor-like |
UniProt Annotations
Entry Information
Gene Name
C-8 sterol isomerase ERG2
Protein Entry
ERG2_YEAST
UniProt ID
Species
Yeast (S288c)
Comments
| Comment Type | Description |
|---|---|
| Function | Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols. |
| Miscellaneous | Present with 2640 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Miscellaneous | This protein is a major target of morpholine antibiotics. |
| Pathway | Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 2/5. |
| Similarity | Belongs to the ERG2 family. {ECO:0000305}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006869 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6323858 | RefSeq | NP_013929 | 222 | C-8 sterol isomerase ERG2 |
Identical Sequences to LMP006869 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6323858 | EMBL | CAY82033.1 | 222 | Erg2p [Saccharomyces cerevisiae EC1118] |
| GI:6323858 | GenBank | ADA21804.1 | 222 | Sequence 6 from patent US 7608421 |
| GI:6323858 | GenBank | EWG89471.1 | 222 | Erg2p [Saccharomyces cerevisiae P301] |
| GI:6323858 | GenBank | EWG94136.1 | 222 | Erg2p [Saccharomyces cerevisiae R103] |
| GI:6323858 | GenBank | EWH16794.1 | 222 | Erg2p [Saccharomyces cerevisiae P283] |
| GI:6323858 | Third Party Genbank | DAA10101.1 | 222 | TPA: C-8 sterol isomerase ERG2 [Saccharomyces cerevisiae S288c] |
Related Sequences to LMP006869 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6323858 | DBBJ | GAA25651.1 | 222 | K7_Erg2p [Saccharomyces cerevisiae Kyokai no. 7] |
| GI:6323858 | GenBank | EDN64138.1 | 222 | C-8 sterol isomerase [Saccharomyces cerevisiae YJM789] |
| GI:6323858 | GenBank | EDV11693.1 | 222 | C-8 sterol isomerase [Saccharomyces cerevisiae RM11-1a] |
| GI:6323858 | GenBank | EEU06631.1 | 222 | Erg2p [Saccharomyces cerevisiae JAY291] |
| GI:6323858 | GenBank | EIW08469.1 | 222 | Erg2p [Saccharomyces cerevisiae CEN.PK113-7D] |
| GI:6323858 | gnl | McCuskerlabDuke | 222 | Erg2p [Saccharomyces cerevisiae YJM993] |