Gene/Proteome Database (LMPD)

LMPD ID
LMP006879
Gene ID
853757
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1
Gene Symbol
GFA1
Synonyms
-
Alternate Names
glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1
Chromosome
XI
EC Number
2.6.1.16

Proteins

glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1
Refseq ID NP_012818
Protein GI 6322745
UniProt ID P14742
mRNA ID NM_001179670
Length 717
RefSeq Status PROVISIONAL
MCGIFGYCNYLVERSRGEIIDTLVDGLQRLEYRGYDSTGIAIDGDEADSTFIYKQIGKVSALKEEITKQNPNRDVTFVSHCGIAHTRWATHGRPEQVNCHPQRSDPEDQFVVVHNGIITNFRELKTLLINKGYKFESDTDTECIAKLYLHLYNTNLQNGHDLDFHELTKLVLLELEGSYGLLCKSCHYPNEVIATRKGSPLLIGVKSEKKLKVDFVDVEFPEENAGQPEIPLKSNNKSFGLGPKKAREFEAGSQNANLLPIAANEFNLRHSQSRAFLSEDGSPTPVEFFVSSDAASVVKHTKKVLFLEDDDLAHIYDGELHIHRSRREVGASMTRSIQTLEMELAQIMKGPYDHFMQKEIYEQPESTFNTMRGRIDYENNKVILGGLKAWLPVVRRARRLIMIACGTSYHSCLATRAIFEELSDIPVSVELASDFLDRKCPVFRDDVCVFVSQSGETADTMLALNYCLERGALTVGIVNSVGSSISRVTHCGVHINAGPEIGVASTKAYTSQYIALVMFALSLSDDRVSKIDRRIEIIQGLKLIPGQIKQVLKLEPRIKKLCATELKDQKSLLLLGRGYQFAAALEGALKIKEISYMHSEGVLAGELKHGVLALVDENLPIIAFGTRDSLFPKVVSSIEQVTARKGHPIIICNENDEVWAQKSKSIDLQTLEVPQTVDCLQGLINIIPLQLMSYWLAVNKGIDVDFPRNLAKSVTVE

Gene Information

Entrez Gene ID
853757
Gene Name
glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1
Gene Symbol
GFA1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030246 IEA:InterPro F carbohydrate binding
GO:0004360 IDA:SGD F glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0006048 IEA:UniProtKB-UniPathway P UDP-N-acetylglucosamine biosynthetic process
GO:0034221 IGI:SGD P fungal-type cell wall chitin biosynthetic process
GO:0006541 IEA:UniProtKB-KW P glutamine metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
sce00250 Alanine, aspartate and glutamate metabolism
sce00520 Amino sugar and nucleotide sugar metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5618532 Synthesis of UDP-N-acetyl-glucosamine
5618616 XBP1(S) activates chaperone genes

Domain Information

InterPro Annotations

Accession Description
IPR000583 Class II glutamine amidotransferase domain
IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising
IPR017932 Glutamine amidotransferase type 2 domain
IPR029055 Nucleophile aminohydrolases, N-terminal
IPR001347 Sugar isomerase (SIS)

UniProt Annotations

Entry Information

Gene Name
glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1
Protein Entry
GFA1_YEAST
UniProt ID
P14742
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity L-glutamine + D-fructose 6-phosphate = L- glutamate + D-glucosamine 6-phosphate. {ECO:0000269|PubMed:15699032}.
Function Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins). {ECO:0000269|PubMed:15699032}.
Induction The activity of this enzyme increases in presence of mating pheromone (transcriptional regulation).
Miscellaneous Present with 14300 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D- glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D- fructose 6-phosphate: step 1/1.
Similarity Contains 1 glutamine amidotransferase type-2 domain. {ECO:0000255|PROSITE-ProRule:PRU00609}.
Similarity Contains 2 SIS domains. {ECO:0000255|PROSITE- ProRule:PRU00797}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006879 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6322745 RefSeq NP_012818 717 glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1

Identical Sequences to LMP006879 proteins

Reference Database Accession Length Protein Name
GI:6322745 GenBank AFD38720.1 717 Sequence 18 from patent US 8124381
GI:6322745 GenBank EIW09128.1 717 Gfa1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6322745 GenBank AHB33193.1 717 glutamine-fructose-6-phosphate transaminase [Saccharomyces cerevisiae]
GI:6322745 GenBank EWG84750.1 717 Gfa1p [Saccharomyces cerevisiae R008]
GI:6322745 GenBank EWG90058.1 717 Gfa1p [Saccharomyces cerevisiae P301]
GI:6322745 GenBank EWH17542.1 717 Gfa1p [Saccharomyces cerevisiae P283]

Related Sequences to LMP006879 proteins

Reference Database Accession Length Protein Name
GI:6322745 EMBL CBC85067.1 723 unnamed protein product [Candida glabrata CBS 138]
GI:6322745 GenBank AAA34643.1 716 D-fructose-6-phosphate amidotransferase (EC 2.6.1.16) [Saccharomyces cerevisiae]
GI:6322745 GenBank EHN01531.1 717 Gfa1p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6322745 GenBank EJS42964.1 717 gfa1p [Saccharomyces arboricola H-6]
GI:6322745 GenBank EJT44180.1 717 GFA1-like protein [Saccharomyces kudriavzevii IFO 1802]
GI:6322745 gnl McCuskerlabDuke 717 Gfa1p [Saccharomyces cerevisiae YJM993]