Gene/Proteome Database (LMPD)

LMPD ID
LMP006887
Gene ID
851727
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Num1p
Gene Symbol
NUM1
Synonyms
PAC12
Chromosome
IV

Proteins

Num1p
Refseq ID NP_010434
Protein GI 6320353
UniProt ID Q00402
mRNA ID NM_001180457
Length 2748
MSHNNRHKKNNDKDSSAGQYANSIDNSLSQESVSTNGVTRMANLKADECGSGDEGDKTKRFSISSILSKRETKDVLPEFAGSSSHNGVLTANSSKDMNFTLELSENLLVECRKLQSSNEAKNEQIKSLKQIKESLSDKIEELTNQKKSFMKELDSTKDLNWDLESKLTNLSMECRQLKELKKKTEKSWNDEKESLKLLKTDLEILTLTKNGMENDLSSQKLHYDKEISELKERILDLNNENDRLLISVSDLTSEINSLQSNRTERIKIQKQLDDAKASISSLKRKVQKKYYQKQHTSDTTVTSDPDSEGTTSEEDIFDIVIEIDHMIETGPSVEDISEDLVKKYSEKNNMILLSNDSYKNLLQKSESASKPKDDELMTKEVAENLNMIALPNDDNYSKKEFSLESHIKYLEASGYKVLPLEEFENLNESLSNPSYNYLKEKLQALKKIPIDQSTFNLLKEPTIDFLLPLTSKIDCLIIPTKDYNDLFESVKNPSIEQMKKCLEAKNDLQSNICKWLEERNGCKWLSNDLYFSMVNKIETPSKQYLSDKAKEYDQVLIDTKALEGLKNPTIDFLREKASASDYLLLKKEDYVSPSLEYLVEHAKATNHHLLSDSAYEDLVKCKENPDMEFLKEKSAKLGHTVVSNEAYSELEKKLEQPSLEYLVEHAKATNHHLLSDSAYEDLVKCKENPDMEFLKEKSAKLGHTVVSNEAYSELQRKYSELEKEVEQPSLAYLVEHAKATDHHLLSDSAYEDLVKCKENPDVEFLKEKSAKLGHTVVSSEEYSELQRKYSELEKEVEQPSLAYLVEHAKATDHHLLSDSAYEELVKCKENPDMEFLKEKSAKLGHTVVSNEAYSELEKKLEQPSLAYLVEHAKATDHHLLSDSAYEDLVKCKENSDVEFLKEKSAKLGHTVVSNEAYSELEKKLEQPSLAYLVEHAKATDHHLLSDSAYEDLVKCKENPDMEFLKEKSAKLGHTVVSNEAYSELEKKLEQPSLEYLVEHAKATNHHLLSDSAYEDLVKCKENPDMEFLKEKSAKLGHTVVSNEAYSELEKKLEQPSLEYLVEHAKATNHHLLSDSAYEELVKCKENPDVEFLKEKSAKLGHTVVSNEAYSELEKKLEQPSLEYLVEHAKATNHHLLSDSAYEELVKCKENPDVEFLKEKSAKLGHTVVSNEAYSELEKKLEQPSLAYLVEHAKATDHHLLSDSAYEDLVKCKENPDVEFLKEKSAKLGHTVVSNEAYSELEKKLEQPSLAYLVEHAKATDHHLLSDSAYEDLVKCKENPDMEFLKEKSAKLGHTVVSNEAYSELEKKLEQPSLEYLVEHAKATNHHLLSDSAYEDLVKCKENPDMEFLKEKSAKLGHTVVSNKEYSELEKKLEQPSLEYLVKHAEQIQSKIISISDFNTLANPSMEDMASKLQKLEYQIVSNDEYIALKNTMEKPDVELLRSKLKGYHIIDTTTYNELVSNFNSPTLKFIEEKAKSKGYRLIEPNEYLDLNRIATTPSKEEIDNFCKQIGCYALDSKEYERLKNSLENPSKKFIEENAALLDLVLVDKTEYQAMKDNASNKKSLIPSTKALDFVTMPAPQLASAEKSSLQKRTLSDIENELKALGYVAIRKENLPNLEKPIVDNASKNDVLNLCSKFSLVPLSTEEYDNMRKEHTKILNILGDPSIDFLKEKCEKYQMLIISKHDYEEKQEAIENPGYEFILEKASALGYELVSEVELDRMKQMIDSPDIDYMQEKAARNEMVLLRNEEKEALQKKIEYPSLTFLIEKAAGMNKILVDQIEYDETIRKCNHPTRMELEESCHHLNLVLLDQNEYSTLREPLENRNVEDLINTLSKLNYIAIPNTIYQDLIGKYENPNFDYLKDSLNKMDYVAISRQDYELMVAKYEKPQLDYLKISSEKIDHIVVPLSEYNLMVTNYRNPSLSYLKEKAVLNNHILIKEDDYKNILAVSEHPTVIHLSEKASLLNKVLVDKDDFATMSRSIEKPTIDFLSTKALSMGKILVNESTHKRNEKLLSEPDSEFLTMKAKEQGLIIISEKEYSELRDQIDRPSLDVLKEKAAIFDSIIVENIEYQQLVNTTSPCPPITYEDLKVYAHQFGMELCLQKPNKLSGAERAERIDEQSINTTSSNSTTTSSMFTDALDDNIEELNRVELQNNEDYTDIISKSSTVKDATIFIPAYENIKNSAEKLGYKLVPFEKSNINLKNIEAPLFSKDNDDTSVASSIDLDHLSRKAEKYGMTLISDQEFEEYHILKDNAVNLNGGMEEMNNPLSENQNLAAKTTNTAQEGAFQNTVPHNDMDNEEVEYGPDDPTFTVRQLKKPAGDRNLILTSREKTLLSRDDNIMSQNEAVYGDDISDSFVDESQEIKNDVDIIKTQAMKYGMLCIPESNFVGASYASAQDMSDIVVLSASYYHNLMSPEDMKWNCVSNEELQAEVKKRGLQIALTTKEDKKGQATASKHEYVSHKLNNKTSTVSTKSGAKKGLAEAAATTAYEDSESHPQIEEQSHRTNHHKHHKRQQSLNSNSTSKTTHSSRNTPASRRDIVASFMSRAGSASRTASLQTLASLNEPSIIPALTQTVIGEYLFKYYPRLGPFGFESRHERFFWVHPYTLTLYWSASNPILENPANTKTKGVAILGVESVTDPNPYPTGLYHKSIVVTTETRTIKFTCPTRQRHNIWYNSLRYLLQRNMQGISLEDIADDPTDNMYSGKIFPLPGENTKSSSKRLSASRRSVSTRSLRHRVPQSRSFGNLR

Gene Information

Entrez Gene ID
851727
Gene Name
Num1p
Gene Symbol
NUM1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005938 IDA:SGD C cell cortex
GO:0005934 IDA:SGD C cellular bud tip
GO:0005783 IDA:SGD C endoplasmic reticulum
GO:0005543 IEA:InterPro F phospholipid binding
GO:0015631 IPI:SGD F tubulin binding
GO:0032065 IEA:InterPro P cortical protein anchoring
GO:0000226 IMP:SGD P microtubule cytoskeleton organization
GO:0000266 IMP:SGD P mitochondrial fission
GO:0000001 IGI:SGD P mitochondrion inheritance
GO:0051646 IMP:SGD P mitochondrion localization
GO:0030473 IMP:SGD P nuclear migration along microtubule

Domain Information

InterPro Annotations

Accession Description
IPR024774 PH_dom-Mcp5-type
IPR001849 Pleckstrin homology domain

UniProt Annotations

Entry Information

Gene Name
Num1p
Protein Entry
NUM1_YEAST
UniProt ID
Q00402
Species
Yeast (S288c)

Comments

Comment Type Description
Function Controls nuclear migration. NUM1 specifically controls the interaction of the bud neck cytoskeleton with the pre- divisional G2 nucleus. Functions in dynein-anchoring. During late anaphase forms dynein-interacting cortical microtubule capture sites at both cellular poles. This leads to dynein-dependent sliding of the microtubules in the bud. {ECO:0000269|PubMed:11121446, ECO:0000269|PubMed:11266443, ECO:0000269|PubMed:1745235, ECO:0000269|PubMed:7490278}.
Interaction P09734:TUB3; NbExp=2; IntAct=EBI-12386, EBI-18981;
Miscellaneous Additional regions of lower homology to the repeat consensus (always starting with proline) are found in both flanking domains of the tandem repeats.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular Location Bud tip {ECO:0000269|PubMed:11121446, ECO:0000269|PubMed:11266443, ECO:0000269|PubMed:7490278}.
Subunit Interacts with PAC11 when DYN1 is present, and TUB3
Subunit Interacts with PAC11 when DYN1 is present, and TUB3. {ECO:0000269|PubMed:11266443}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006887 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6320353 RefSeq NP_010434 2748 Num1p

Identical Sequences to LMP006887 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP006887 proteins

Reference Database Accession Length Protein Name